Patent search ap:("UCB PHARMA SA") AND inv:"LALLEMAND BENEDICTE" Page 1

1.

发明专利
DERIVADO DE 2-OXO-1-PIRROLIDINA Y SUS USOS FARMACEUTICOS. 未知

公开(公告)号：ES2334998T3

公开(公告)日：2010-03-18

申请号：ES04007878

申请日：2001-02-21

Applicant: UCB PHARMA SA

Inventor： DIFFERDING EDMOND , KENDA BENOIT , LALLEMAND BENEDICTE , MATAGNE ALAIN , MICHEL PHILIPPE , PASAU PATRICK

IPC: C07D207/27 , C07D401/04 , A61K31/4015 , A61K31/4025 , A61K31/41 , A61K31/4178 , A61K31/4188 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/541 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/16 , A61P37/08 , C07B61/00 , C07C237/06 , C07C237/12 , C07D207/26 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04

Abstract: Un compuesto seleccionado de los diastereoisómeros (4R) y (4S) de (2S)-2-[2-oxo-4-propilpirrolidinil]butanamida o una de sus sales farmacéuticamente aceptables.

2.

发明专利
2-OXO-1-PYRROLIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES 未知

公开(公告)号：MY138966A

公开(公告)日：2009-08-28

申请号：MYPI20010775

申请日：2001-02-21

Applicant: UCB PHARMA SA

Inventor： DIFFERDING EDMOND , KENDA BENOIT , LALLEMAND BENEDICTE , MATAGNE ALAIN , MICHEL PHILIPPE , PASAU PATRICK , TALAGA PATRICE

IPC: C07D401/04 , A61K31/4015 , A61K31/4025 , A61K31/41 , A61K31/4178 , A61K31/4188 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/541 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/16 , A61P37/08 , C07B61/00 , C07C237/06 , C07C237/12 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/277 , C07D277/20 , C07D307/33 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04

Abstract: THE INVENTION CONCERNS 2-OXO-1-PYRROLIDINE DERIVATIVES OF FORMULA 1,@@@(I)@WHEREIN THE SUBSTITUENTS ARE AS DEFINED IN THE SPECIFICATION, AS WELL AS THEIR USE AS PHARMACEUTICALS. THE COMPOUNDS OF THE INVENTION ARE PARTICULALRY SUITED FOR TREATING NEUROLOGICAL DISORDERS SUCH AS EPILEPSY.

3.

发明专利
@@oxó@@@pýrrólidín@afleiða@og@lyfjafræðileg@notkun@hennar 未知

公开(公告)号：IS2754B

公开(公告)日：2011-09-15

申请号：IS7922

申请日：2005-06-29

Applicant: UCB PHARMA SA

Inventor： DIFFERDING EDMOND , KENDA BENOIT , LALLEMAND BENEDICTE , MATAGNE ALAIN , MICHEL PHILIPPE , PASAU PATRICK , TALAGA PATRICE

IPC: C07D207/27 , C07D401/04 , A61K31/4015 , A61K31/4025 , A61K31/41 , A61K31/4178 , A61K31/4188 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/541 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/16 , A61P37/08 , C07B61/00 , C07C237/06 , C07C237/12 , C07D207/26 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04

4.

发明专利
2-OXO-1-PYRROLIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES 未知

公开(公告)号：HU229514B1

公开(公告)日：2014-01-28

申请号：HU0204526

申请日：2001-02-21

Applicant: UCB PHARMA SA

Inventor： DIFFERDING EDMOND , KENDA BENOLT , LALLEMAND BENEDICTE , MATAGNE ALAIN , MICHEL PHILIPPE , PASAU PATRICK , TALAGA PATRICE

IPC: C07D207/27 , C07D401/04 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/41 , A61K31/4178 , A61K31/4188 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/541 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/16 , A61P37/08 , C07B61/00 , C07C237/06 , C07C237/12 , C07D207/26 , C07D207/273 , C07D207/277 , C07D307/33 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D495/04

Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives of general formula (B. geometrical isomers, enantiomers, diastereoisomers, mixtures of each of these and pharmaceutically acceptable salts thereof. whereinR 1 is methyl,R 2 and R 4 are hydrogen.R 3 is alkyl or haloalkenyl, andX is -COOH. -COOMe or -COOEt.

5.

发明专利
DERIVADOS DE TIAZOL CONDENSADOS COMO INHIBIDORES DE QUINASA. 未知

公开(公告)号：ES2365258T3

公开(公告)日：2011-09-27

申请号：ES07733382

申请日：2007-06-26

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI , AUJLA PAVANDEEP , CREPY KAREN , FOLEY ANNE , FRANKLIN RICHARD , HAUGHAN ALAN , HORSLEY HELEN , JONES WILLIAM , LALLEMAND BENEDICTE , MACK STEPHEN , MORGAN TREVOR , PASAU PATRICK , PHILLIPS DAVID , SABIN VERITY , BUCKLEY GEORGE , JENKINS KERRY , PERRY BENJAMIN

IPC: C07D513/04 , A61K31/437 , A61K31/519 , C07D513/12 , C07D519/00

Abstract: Un compuesto de fórmula (I), o una de sus sales o solvatos farmacéuticamente aceptables: en la que, X representa oxígeno o azufre; Y representa un grupo de fórmula CR 6 R 7 o NR 8 ; R 1 representa hidrógeno o alquilo(C1-6); y R 2 representa hidrógeno; o alquilo(C1-6), alcoxi(C1-6), cicloalquilo(C3-7), cicloalquil(C3-7)alquilo(C1-6), arilo, arilalquilo(C1-6), heterocicloalquilo(C3-7), heterocicloalquil(C3-7)alquilo(C1-6), heteroarilo o heteroarilalquilo(C1-6), cualquiera de los cuales puede estar opcionalmente sustituido por uno o más sustituyentes seleccionados de halógeno, ciano, nitro, alquilo(C1-6), trifluorometilo, hidroxi, alcoxi(C1-6), difluorometoxi, trifluorometoxi, ariloxi, alquil(C1-6)tio, alquil(C1-6)sulfonilo, amino, alquil(C1-6)amino, dialquil(C1-6)amino, alquil(C2-6)carbonilamino, alcoxi(C2-6)carbonilamino, alquil(C1-6)sulfonilamino, formilo, alquil(C2-6)carbonilo, carboxi, alcoxi(C2-6)carbonilo, aminocarbonilo, alquil(C1-6)aminocarbonilo, dialquil(C1 6)aminocarbonilo, aminosulfonilo, alquil(C1-6)aminosulfonilo y dialquil(C1-6)aminosulfonilo; o R 1 y R 2 , cuando se consideran conjuntamente con el átomo de carbono al cual ambos están unidos, representan cicloalquilo C3-7 o heterocicloalquilo C3-7; R 3 y R 4 representan independientemente hidrógeno; o alquilo(C1-6), alquinilo(C2-6), cicloalquilo(C3-7), cicloalquil(C3-7)alquilo(C1-6), arilo, arilalquilo(C1-6), arilalquenilo(C2-6), arilalquinilo(C2-6), biarilalquilo(C1-6), heterocicloalquilo(C3-7), heterocicloalquil(C3-7)alquilo(C1-6), heterocicloalquil(C3-7)carbonilo, heteroarilo, heteroarilalquilo(C1-6), heteroaril-arilalquilo(C1-6), o aril-heteroarilalquilo(C1-6), cualquiera de los cuales puede estar opcionalmente sustituido por uno o más sustituyentes seleccionados de halógeno, ciano, nitro, alquilo(C1-6), alquenilo(C2-6), cicloalquilo(C3-7), alquil(C1-6)arilo, dialquil(C1-6)arilo, piperidinilalquil(C1-6)arilo, piperazinilalquil(C1-6)arilo, alquil(C1-6)piperazinilalquil(C1-6)arilo, morfolinilalquil(C1-6)arilo, alcoxi(C1-6)arilo, cianoalcoxi(C1-6)arilo, dialquil(C1-6)aminoalquil(C1-6)arilo, alquil(C1-6)aminocarbonilarilo, arilalquilo(C1-6), oxazolinilo, azetidinilo, haloarilpirrolidinilo, dioxopirrolidinilo, aminopirrolidinilo, dialquil(C1-6)aminopirrolidinilo, indolinilo, oxoindolinilo, arilpiperidinilo, arilcarbonilpiperidinilo, dialquil(C1-6)aminocarbonilpiperidinilo, piperazinilo, alquil(C1-6)piperazinilo, haloarilpiperazinilo, piridinilpiperazinilo, furoílpiperazinilo, homopiperazinilo, alquil(C1-6)homopiperazinilo, morfolinilo, alquil(C1-6)piperazinilalquilo((C1-6), morfolinilalquilo(C1-6), benzofurilo, benzotienilo, pirazolilo, alquil(C1-6)pirazolilo, dialquil(C1-6)pirazolilo,trialquil(C1-6)pirazolilo, [dialquil(C1-6)](trifluorometil)pirazolilo, cianoalquil(C1-6)pirazolilo, [ciano-alquil(C1 6)][dialquil(C1-6)]pirazolilo, hidroxialquil(C1-6)pirazolilo, [hidroxialquil(C1-6)][dialquil(C1-6)]pirazolilo, metoxialquil(C1-6)pirazolilo, [(hidroxi)(metoxi)(C1-6)-alquil]pirazolilo, aminoalquil(C1-6)pirazolilo, [(alquil(C1 6)][aminoalquil(C1-6)]pirazolilo, [aminoalquil(C1-6)]dialquil(C1-6)]pirazolilo, dialquil(C1-6)aminoalquil(C1-6)pirazolilo, dialcoxi(C1-6)fosfonoalquil(C1-6)pirazolilo, alquenil(C2-6)pirazolilo, cicloalquil(C3-7)alquil(C1-6)pirazolilo, [cicloalquil(C3-7)alquil(C1-6)][dialquil(C1-6)]pirazolilo, [alquil(C1-6)](aril)pirazolilo, (aril)(trifluorometil)priazolilo, arilalquil(C1-6)pirazolilo, aminoarilalquil(C1-6)pirazolilo, piperidinilpirazolilo, tetrahidropiranilalquil(C1-6)pirazolilo, [di-alquil(C1-6)][tetrahidropiranilalquil(C1-6)]pirazolilo, pirrolidinilalquil(C1-6)pirazolilo, piperidinilalquil(C1 6)pirazolilo, alquil(C1-6)piperidinilalquil(C1-6)pirazolilo, morfolinilalquil(C1-6)pirazolilo, piridinilalquil(C1-6)pirazolilo, oxipiridinilalquil(C1-6)-pirazolilo, [arilcarbonilalquil(C1-6)][dialquil(C1-6)]pirazolilo, [arilcarbonilalquil(C1 6)][dialquil(C1-6)]pirazolilo, [alquil(C1-6)](piperazinilcarbonil)pirazolilo, [alquil(C1-6)aminocarbonil][alquil(C1 6)aril]pirazolilo, [alquil(C1-6)][aminoalquil(C1-6)aminocarbonil]pirazolilo, aminocarbonilalquil(C1-6)pirazolilo, [aminocarbonilalquil(C1-6)][dialquil(C1-6)]pirazolilo, dialquil(C1-6)aminocarbonil-alquilpirazolil(C1-6), pirazolo[1,5α]piridinilo, dialquil(C1-6)isoxazolilo, (amino)[ alquil(C1-6)]isoxazolilo, tiazolilo, dialquil(C1-6)tiazolilo, imidazolilo, alquil(C1-6)imidazolilo, dialquil(C1-6)imidazolilo, imidazo[1,2-α]piridinilo, alquil(C1-6)imidazo[1,2-α]piridinilo, alquil(C1-6)imidazo[4,5-b]piridinilo, imidazo[1,2-α]pirimidinilo, imidazo[1,2-α]pirazinilo, alquil(C1-6)tiadiazolilo, triazolilo, piridinilo, halopiridinilo, alquil(C1-6)piridinilo, [alquil(C1-6)](halo)piridinilo, dialquil(C1-6)piridinilo, alquenil(C2-6)piridinilo, alquil(C1-6)piperazinilpiridinilo, [alquil(C1-6)](piperazinil)piridinilo, [alcoxi(C1 6)carbonilpiperazinil][alquil(C1-6)]piridinilo, piperidinilalquil(C1-6)pirinidilo [alquil(C1-6)](oxi)piridinilo, hidroxipiridinilo, hidroxialquil(C1-6)pirinidilo, alcoxi(C1-6)piridinilo, [alcoxi(C1-6)][alquil(C1-6)]piridinilo, [alcoxi(C1 6)][dialquil(C1-6)]piridinilo, alcoxialquil(C1-6)piridinilo, aminopiridinilo, carboxialquil(C1-6)piridinilo, alcoxi(C1 6)carbonilalquil(C1-6)piridinilo, piridazinilo, alquil(C1-6)piridazinilo, piperidinilpiperazinilo, oxipiridazinilo, alcoxi(C1-6)piridazinilo, aminopiridazinilo, hidroxialquil(C1-6)amino-piridazinilo, dialquil(C1-6)aminopiridazinilo, pirimidinilo, alquil(C1-6)pirimidinilo, [alquil(C1-6)](halo)pirimidinilo, dialquil(C1-6)pirimidinilo, pirrolidinilpirimidinilo, alquil(C1-6)piperazinilpirimidinilo, [alquil(C1-6)](piperazinil)pirimidinilo, [alcoxi(C1-6)carbonilo][alquil(C1 6)]piperazinilpirimidinilo, hidroxiprimidinilo, [alquil(C1-6)](hidroxi)pirimidinilo, [alquil(C1-6)]hidroxialquil(C1 6)]pirimidinilo, [alquil(C1-6)]-[hidroxialquinil(C2-6)]pirimidinilo, alcoxi(C1-6)pirimidinilo, aminopirimidinilo, dialquil(C1-6)aminopirimidinilo, [dialquil(C1-6)amino](halo)pirimidinilo, carboxipirimidinilo, [alcoxi(C1 6)carbonilalquil(C1-6)][alquil(C1-6)]pirimidinilo, aminocarbonilpirimidinilo, pirazinilo, alcoxi(C1-6)pirazinilo, aminopirazinilo, hidroxi, alcoxi(C1-6), difluorometoxi, trifluorometoxi, cicloalcoxi C3-7, cicloalquil(C3-7)alcoxi(C1-6), arilalcoxi(C1-6)carbonilpiperidiniloxi, morfolinilalcoxi(C1-6), ariloxi, haloariloxi, dialquil(C1-6)pirazoliloxi, halopiridiniloxi, pirrolidinilpiridiniloxi, alquil(C1-6)piperazinilpiridiniloxi, alquil(C1-6)pirazolilpiridiniloxi, alquil(C1 6)aminopiridiniloxi, carboxipiridiniloxi, aminocarbonilpiridiniloxi, alquil(C1-6)piridazililoxi, pirimidiniloxi, alquil(C1 6)pirimidiniloxi, [alquil(C1-6)](halo)pirimidiniloxi, hidroxialquilo(C1-6), dihidroxialquilo(C1-6), piridiniloxialquilo(C1-6), amino, alquil(C1-6)amino, dihidroxialquil(C1-6)amino, alcoxi(C1-6)alquil(C1-6)amino, N-[alcoxi(C1-6)-alquil(C1-6)] N-[alquil(C1-6)]amino, dialquil(C1-6)aminoalquil(C1-6)amino, N-[(alquil(C1-6)]-N-[dialquil(C1-6)aminoalquil(C1 6)]amino, N-[alquil(C1-6)]-N-[cicloalquil(C3-7)]amino, haloarilamino, N-[alquil(C1-6),]-N-(haloaril)amino, metilendioxifenilamino, morfonilinlalquil(C1-6)fenilamino, oxazolinilfenilamino, [alquil(C1-6)](oxo)pirazolilfenilamino, oxazolilfenilamino, isoxazolilfenilamino, triazolilfenilamino, alquil(C1-6)triazolilfenilamino, alquil(C1 6)pirimidinilfenilamino, [alquil(C1-6)](oxo)pirazolil-fenilamino, oxazolilfenilamino, isoxazolilfenilamino, triazolilfenilamino, alquil(C1-6)triazolilfenilamino, alquil(C1-6)pirimidinilfenilamino, pirazolil(C1-6)alquilfenilamino, triazolilalquil(C1-6)fenialamino, alquil(C1-6)sulfonilaminofenilamino, morfolinilcarbonilfenilamino, alquil(C1 6)sulfonilfenilamino, morfolinilsulfonilfenilamino, N-[alquil(C1-6)]-N-[arilalquil(C1-6)]amino, N-[dialquil(C1 6)aminoalquil(C1-6)]-N-[arilalquil(C1-6)]amino, N-[di-alquil(C1-6)aminoalquil(C1-6),]-N-[arilalquil(C1-6),]amino, cianoarilalquil(C1-6)amino, (ciano(halo)arilalquil(C1-6)amino, metilendioxiarilalquil(C1-6)amino, dihidrobenzofuranilamino, N-[alquil(C1-6)]-N-[alquil(C1-6)pirrolidinil]amino, alquil(C1-6)sulfonilindolinilamino, cromanonilamino, piperidinilamino, N-[alquil(C1-6)]-N-(piperidinil)amino, N-[cicloalquil(C3-7)alquil(C1-6)-N (piperidinil)-amino, alquil(C1-6)piperidinilamino, N-[alquil(C1-6]-N-[alquil(C1-6)piperidinil]amino, N-[alquil(C1-6)] N-[cicloalquil(C3-7)piperidinil]amino, N-[(C1-6)alquil]-N-[alquil(C2-6)carbonilpiperidinil]-amino, dihidroquinolinonilamino, benzoxazinonilamino, pirrolidinilalquil(C1-6)amino, N-[alquil(C1-6)]-N [pirrolidinilalquil(C1-6)]amino, N-[alquil(C1-6)]-N-[piperidinilalquil(C1-6)]amino, benzotienilamino, indolilamino, dioxoindolilamino, alquil(C1-6)pirazolilamino, [alquil(C1-6)](halo)pirazolilamino, dialquil(C1-6)pirazolilamino, trialquil(C1-6)-pirazolilamino, N-[alquil(C1-6)]-N-[alquil(C1-6)pirazolil]amino, alquil(C1-6)indazolilamino, benzoxazolilamino, benzoxazolonilamino, dialquil(C1-6)isoxazolilamino, tiazolilamino, benzotiazolilamino, alquil(C1-6)ixotiazolilamino, imidazolilamino, [alcoxi(C1-6)carbonil][alquil(C1-6)]imidazolilamino, alquil(C1 6)bencimidazolilamino, bencimidazolonilamino, dialquil(C1-6)bencimidazolonilamino, alquil(C1-6)oxadiazolilamino, furiloxadiazolilamino, alquil(C1-6)tiadiazolilamino, piridinilamino, halopiridinilamino, alquil(C1 6)piridinilamino, dialquil(C1-6)piridinilamino, trifluorometilpiridinilamino, hidroxipiridinilamino, hidroxialquil(C1 6)piridinilamino, dihidroxialquil(C1-6)piridinilamino, alcoxi(C1-6)piridinilamino, dihidroxialcoxi(C1-6)-piridinilamino, dialquil(C1-6)dioxolanilalcoxi(C1-6)piridinilamino, alcoxi(C1-6)alquil(C1-6)piridinilamino, alcoxi(C1-6)alquenil(C2 6)piridinilamino, dihidroxialquil(C1-6)aminopiridinilamino, dialquil(C1-6)aminopiridinilamino, alquil(C1-6)aminoalquil(C1-6)piridinilamino, dialquil(C1-6)aminoalquil(C1-6)piridinilamino, oxopiridinilamino, carboxipiridinilamino, N-[alquil(C1-6)]-N-[alquil(C1-6)piridinil]amino, bis[alquil(C1-6)-piridinil]amino, bis(trifluorometilpiridinil)amino, i

6.

发明专利
未知

公开(公告)号：AT510840T

公开(公告)日：2011-06-15

申请号：AT07733382

申请日：2007-06-26

Applicant: UCB PHARMA SA

Inventor： ALEXANDER RIKKI , AUJLA PAVANDEEP , CREPY KAREN , FOLEY ANNE , FRANKLIN RICHARD , HAUGHAN ALAN , HORSLEY HELEN , JONES WILLIAM , LALLEMAND BENEDICTE , MACK STEPHEN , MORGAN TREVOR , PASAU PATRICK , PHILLIPS DAVID , SABIN VERITY , BUCKLEY GEORGE , JENKINS KERRY , PERRY BENJAMIN

IPC: C07D513/04 , A61K31/437 , A61K31/519 , C07D513/12 , C07D519/00

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.