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    2.
    发明专利
    未知

    公开(公告)号：DK154078C

    公开(公告)日：1989-05-22

    申请号：DK44082

    申请日：1982-02-01

    Applicant: UCB SA

    Inventor： BALTES EUGENE ,  LANNOY JEAN DE ,  RODRIGUEZ LUDOVIC

    IPC: C07D295/08 ,  A61K31/495 ,  A61P37/08 ,  C07D295/088

    Abstract: New 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids, their amides and their salts, processes for the preparation thereof and therapeutic compositions. These compounds have the formula wherein Y=-OH or -NH2; X and X'=H, halogen, alkoxy or trifluoromethyl; m=1 or 2 and n=1 or 2. The amides of the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared either by reacting a 1-(diphenylmethyl)-piperazine with an omegahaloacetamide, or by reacting an alkali metal salt of an omega-[4-(diphenylmethyl)-1-piperazinyl]-alkanol with a 2-haloacetamide, or yet by reacting ammonia with a halide or alkyl ester of a 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid, whereas the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester. These compounds have in particular an antiallergic, spasmolytic and antihistaminic activity.

    6.
    发明专利
    未知

    公开(公告)号：DK149133B

    公开(公告)日：1986-02-10

    申请号：DK408781

    申请日：1981-09-14

    Applicant: UCB SA

    Inventor： RODRIGUEZ LUDOVIC ,  BALTES EUGENE

    IPC: A61K31/445 ,  A61K31/451 ,  A61K31/452 ,  A61P11/00 ,  A61P11/08 ,  A61P25/20 ,  A61P37/08 ,  A61P43/00 ,  C07D211/70

    Abstract: New 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acids and their amides, processes for the preparation thereof and therapeutic compositions. These compounds have the formula wherein Y=-OH or -NR1R2, R1 and R2=H, alkyl or phenyl; X=H, halogen or alkoxy; m=0, 1 or 2 and n=1 or 2. The 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester, whereas the amides are prepared either by reacting a 4-(diphenylmethylene)-piperidine with an omega-haloacetamide, or by reacting an alkali metal salt of an omega-[4-diphenylmethylene)-1-piperidinyl]-alkanol (m=1 or 2) with a 2-haloacetamide, or by reacting a nitrogen compound (HNR1R2) with a halide or alkyl ester of a 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acid. These compounds have in particular an antiallergic, spasmolytic, antihistaminic and broncholytic activity.

    10.
    发明专利
    未知

    公开(公告)号：FI812852L

    公开(公告)日：1982-03-19

    申请号：FI812852

    申请日：1981-09-14

    Applicant: UCB SA

    Inventor： RODRIGUEZ LUDOVIC ,  BALTES EUGENE

    IPC: A61K31/445 ,  A61K31/451 ,  A61K31/452 ,  A61P11/00 ,  A61P11/08 ,  A61P25/20 ,  A61P37/08 ,  A61P43/00 ,  C07D211/70 ,  C07D

    Abstract: New 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acids and their amides, processes for the preparation thereof and therapeutic compositions. These compounds have the formula wherein Y=-OH or -NR1R2, R1 and R2=H, alkyl or phenyl; X=H, halogen or alkoxy; m=0, 1 or 2 and n=1 or 2. The 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester, whereas the amides are prepared either by reacting a 4-(diphenylmethylene)-piperidine with an omega-haloacetamide, or by reacting an alkali metal salt of an omega-[4-diphenylmethylene)-1-piperidinyl]-alkanol (m=1 or 2) with a 2-haloacetamide, or by reacting a nitrogen compound (HNR1R2) with a halide or alkyl ester of a 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acid. These compounds have in particular an antiallergic, spasmolytic, antihistaminic and broncholytic activity.

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