公开(公告)号：JPS57149282A

公开(公告)日：1982-09-14

申请号：JP1739282

申请日：1982-02-05

Applicant: UCB SA

Inventor： BALTES EUGENE ,  LANNOY JEAN DE ,  RODRIGUEZ LUDOVIC

IPC: C07D295/06 ,  A61K31/495 ,  A61P11/06 ,  A61P11/08 ,  A61P37/08 ,  A61P43/00 ,  C07D20060101 ,  C07D295/04 ,  C07D295/08

公开(公告)号：DK154078C

公开(公告)日：1989-05-22

申请号：DK44082

申请日：1982-02-01

Applicant: UCB SA

Inventor： BALTES EUGENE ,  LANNOY JEAN DE ,  RODRIGUEZ LUDOVIC

IPC: C07D295/08 ,  A61K31/495 ,  A61P37/08 ,  C07D295/088

Abstract: New 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids, their amides and their salts, processes for the preparation thereof and therapeutic compositions. These compounds have the formula wherein Y=-OH or -NH2; X and X'=H, halogen, alkoxy or trifluoromethyl; m=1 or 2 and n=1 or 2. The amides of the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared either by reacting a 1-(diphenylmethyl)-piperazine with an omegahaloacetamide, or by reacting an alkali metal salt of an omega-[4-(diphenylmethyl)-1-piperazinyl]-alkanol with a 2-haloacetamide, or yet by reacting ammonia with a halide or alkyl ester of a 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid, whereas the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester. These compounds have in particular an antiallergic, spasmolytic and antihistaminic activity.

公开(公告)号：ZA82752B

公开(公告)日：1982-12-29

申请号：ZA82752

申请日：1982-02-05

Applicant: UCB SA

Inventor： BALTES EUGENE ,  LANNOY JEAN DE ,  RODRIGUEZ LUDOVIC

IPC: C07D295/06 ,  A61K31/495 ,  A61P11/06 ,  A61P11/08 ,  A61P37/08 ,  A61P43/00 ,  C07D20060101 ,  C07D295/04 ,  C07D295/08 ,  C07D

公开(公告)号：ZA8200752B

公开(公告)日：1982-12-29

申请号：ZA8200752

申请日：1982-02-05

Applicant: UCB SA

Inventor： BALTES EUGENE ,  LANNOY JEAN DE ,  RODRIGUEZ LUDOVIC

IPC: C07D295/06 ,  A61K31/495 ,  A61P11/06 ,  A61P11/08 ,  A61P37/08 ,  A61P43/00 ,  C07D20060101 ,  C07D295/04 ,  C07D295/08 ,  C07D

公开(公告)号：NO780431A

公开(公告)日：1978-08-11

申请号：NO780431

申请日：1978-02-08

Applicant: UCB SA

Inventor： LANNOY JEAN DE

IPC: A61K31/40 ,  A61K31/4015 ,  A61K31/445 ,  A61K31/45 ,  A61K31/55 ,  A61P7/02 ,  A61P25/28 ,  C07D207/00 ,  C07D207/12 ,  C07D207/22 ,  C07D207/26 ,  C07D207/27 ,  C07D211/40 ,  C07D211/76 ,  C07D223/00 ,  C07D223/10 ,  C07D225/02 ,  C07D227/08 ,  C07D227/087 ,  C07D403/12 ,  C07D

CPC classification number: C07D207/27 ,  C07D207/26 ,  C07D211/76 ,  C07D223/10 ,  C07D225/02 ,  C07D227/08

公开(公告)号：DK5388D0

公开(公告)日：1988-01-07

申请号：DK5388

申请日：1988-01-07

Applicant: UCB SA

Inventor： BALTES EUGENE ,  LANNOY JEAN DE ,  RODRIGUEZ LUDOVIC

IPC: C07D295/08 ,  A61K31/495 ,  A61P37/08 ,  C07D295/088

Abstract: New 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids, their amides and their salts, processes for the preparation thereof and therapeutic compositions. These compounds have the formula wherein Y=-OH or -NH2; X and X'=H, halogen, alkoxy or trifluoromethyl; m=1 or 2 and n=1 or 2. The amides of the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared either by reacting a 1-(diphenylmethyl)-piperazine with an omegahaloacetamide, or by reacting an alkali metal salt of an omega-[4-(diphenylmethyl)-1-piperazinyl]-alkanol with a 2-haloacetamide, or yet by reacting ammonia with a halide or alkyl ester of a 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid, whereas the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester. These compounds have in particular an antiallergic, spasmolytic and antihistaminic activity.

公开(公告)号：CA1199918A

公开(公告)日：1986-01-28

申请号：CA395464

申请日：1982-02-03

Applicant: UCB SA

Inventor： BALTES EUGENE ,  LANNOY JEAN DE ,  RODRIGUEZ LUDOVIC

IPC: C07D295/08 ,  A61K31/495 ,  A61P37/08 ,  C07D295/088 ,  C07D295/14

Abstract: New 2¢4-(diphenylmethyl)-l-piperaziny1!-acetic acids, their amides and their salts, processes for the preparation -thereof and therapeutic compositions. These compounds have the formula wherein Y = -OH or -NH2; X and X' = H, halogen, alkoxy or trifluoromethyl; m = 1 or 2 and n = 1 or 2. The amides of the 2-¢4-(diphenylmethyl)-1-piperazinyl!-acetic acids are prepared either by reacting a l-(diphenylmethyl)-piperazine with an omegahaloacetamide, or by reacting an alkali metal salt of an omega-¢4-(diphenyl-methyl)-l-piperazinyl!-alkanol with a 2-haloacetamide, or yet by reacting ammonia with a halide or alkyl ester of a 2-¢4(diphenylmethyl)-1-piperazinyl!-acetic acid, whereas the 2-¢4-(diphenylmethyl)-1-piperazinyl!-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester. These compounds have in particular an antiallergic, spasmolytic and antihistaminic activity.

公开(公告)号：YU23782A

公开(公告)日：1985-06-30

申请号：YU23782

申请日：1982-02-04

Applicant: UCB SA

Inventor： BALTES EUGENE ,  LANNOY JEAN DE ,  RODRIGUEZ LUDOVIC

IPC: A61K31/495 ,  A61P37/08 ,  C07D295/08 ,  C07D295/088 ,  C07D295/16

Abstract: New 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids, their amides and their salts, processes for the preparation thereof and therapeutic compositions. These compounds have the formula wherein Y=-OH or -NH2; X and X'=H, halogen, alkoxy or trifluoromethyl; m=1 or 2 and n=1 or 2. The amides of the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared either by reacting a 1-(diphenylmethyl)-piperazine with an omegahaloacetamide, or by reacting an alkali metal salt of an omega-[4-(diphenylmethyl)-1-piperazinyl]-alkanol with a 2-haloacetamide, or yet by reacting ammonia with a halide or alkyl ester of a 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid, whereas the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester. These compounds have in particular an antiallergic, spasmolytic and antihistaminic activity.

公开(公告)号：AU544066B2

公开(公告)日：1985-05-16

申请号：AU8023182

申请日：1982-02-05

Applicant: UCB SA

Inventor： BALTES EUGENE ,  LANNOY JEAN DE ,  RODRIGUES LUDOVIC

IPC: C07D295/08 ,  A61K31/495 ,  A61P37/08 ,  C07D295/088 ,  C07D295/14

Abstract: New 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids, their amides and their salts, processes for the preparation thereof and therapeutic compositions. These compounds have the formula wherein Y=-OH or -NH2; X and X'=H, halogen, alkoxy or trifluoromethyl; m=1 or 2 and n=1 or 2. The amides of the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared either by reacting a 1-(diphenylmethyl)-piperazine with an omegahaloacetamide, or by reacting an alkali metal salt of an omega-[4-(diphenylmethyl)-1-piperazinyl]-alkanol with a 2-haloacetamide, or yet by reacting ammonia with a halide or alkyl ester of a 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid, whereas the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester. These compounds have in particular an antiallergic, spasmolytic and antihistaminic activity.

公开(公告)号：NZ199650A

公开(公告)日：1984-07-06

申请号：NZ19965082

申请日：1982-02-05

Applicant: UCB SA

Inventor： BALTES EUGENE ,  LANNOY JEAN DE ,  RODRIGUEZ LUDOVIC

IPC: A61K31/495 ,  A61P37/08 ,  C07D295/08 ,  C07D295/088 ,  C07D241

Abstract: New 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids, their amides and their salts, processes for the preparation thereof and therapeutic compositions. These compounds have the formula wherein Y=-OH or -NH2; X and X'=H, halogen, alkoxy or trifluoromethyl; m=1 or 2 and n=1 or 2. The amides of the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared either by reacting a 1-(diphenylmethyl)-piperazine with an omegahaloacetamide, or by reacting an alkali metal salt of an omega-[4-(diphenylmethyl)-1-piperazinyl]-alkanol with a 2-haloacetamide, or yet by reacting ammonia with a halide or alkyl ester of a 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid, whereas the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester. These compounds have in particular an antiallergic, spasmolytic and antihistaminic activity.