公开(公告)号：WO2011014282A3

公开(公告)日：2011-03-31

申请号：PCT/US2010033397

申请日：2010-05-03

Applicant: UNIV BOSTON ,  UNLU SELIM M ,  OZKUMUR EMRE I ,  DAABOUL GEORGE ,  VEDULA RAHUL S ,  GOLDBERG BENNETT B

Inventor： UNLU SELIM M ,  OZKUMUR EMRE I ,  DAABOUL GEORGE ,  VEDULA RAHUL S ,  GOLDBERG BENNETT B

IPC: G01N21/45 ,  G01B9/02 ,  G01B11/06 ,  G01N33/543 ,  G01N33/569

CPC classification number: G01N21/45 ,  G01B11/0625 ,  G01N2021/1776 ,  G01N2021/7779 ,  G01N2201/0627

Abstract: A spectral reflectance imaging device (100) for detecting biomolecular targets (126) includes an illumination source (101) that illuminates a substrate (122) with a plurality of separate wavelengths of incoherent light. The substrate includes an oxide layer (124) and a binding agent to selectively bind biomolecular targets to the substrate. An imaging device (130) captures the light reflected from or transmitted through the substrate and an image processing system (140) detects the biomolecular targets a function of the change in reflective properties of the substrate.

Abstract translation: 用于检测生物分子靶（126）的光谱反射成像装置（100）包括用多个分离的不相干光的波长照射衬底（122）的照明源（101）。 底物包括氧化物层（124）和用于选择性地将生物分子靶标结合到底物的结合剂。 成像装置（130）捕获从衬底反射或透射通过衬底的光，并且图像处理系统（140）检测生物分子靶标是衬底反射性能变化的函数。

公开(公告)号：EP3114429A4

公开(公告)日：2017-11-08

申请号：EP15757686

申请日：2015-03-06

Applicant: UNIV BOSTON

Inventor： UNLU SELIM ,  DAABOUL GEORGE ,  YURT ABDULKADIR

IPC: G01B9/02 ,  G01B9/04 ,  G01N21/21 ,  G01N21/45 ,  G01N21/55

CPC classification number: G01N21/55 ,  G01B9/02011 ,  G01N21/21 ,  G01N21/45 ,  G01N21/554 ,  G01N2021/216 ,  G01N2201/06113 ,  G01N2201/0683

Abstract: An imaging system uses polarized light to illuminate the target and then uses a polarization filter to remove the light that is reflected from the target without modification. The target can include one or more anisotropic objects that scatter the light and alter the polarization state of the reflected light and causing it to be selectively transmitted to the imaging device which can record the transmitted light through the filter. The illuminating light can be circularly polarized and the filter can remove the circularly polarized light. The target can include asymmetric nanoparticles, such as nanorods that alter the amplitude or phase of the scattered light enabling pass through the filter to be detected by the imaging device.