公开(公告)号：AU2003269873A8

公开(公告)日：2003-12-19

申请号：AU2003269873

申请日：2003-05-13

Applicant: UNIV CALIFORNIA

Inventor： LI GUANN-PYNG ,  SIMS CHRISTOPHER E ,  REN XUEGIN ,  HU SHUWEN ,  BACHMAN MARK ,  ALLBRITTON NANCY

IPC: C08J7/18 ,  G01N27/447 ,  G02B1/04 ,  G02C7/04 ,  C08J7/04

Abstract: Polymer-based biomaterials are popular due to ease of fabrication and low costs. However, many polymer substrates have undesirable surface properties. The invention provides a procedure to covalently apply a graft polymer to the surface of a polymer substrate by ultraviolet graft polymerization. The graft polymer is formed from monomers such as PEG, AA, monomethoxy acrylate PEG, HEMA, or DMA. Also, mixed monomers may be used to create the graft and the surface properties of the graft may be tailored for different properties, including hydrophobicity, friction coefficient, electroosmotic mobilities and electrophoretic separations. The invention has particular utility in tailoring surface chemistries in ocular lenses and polymer microdevices. I. II. R: -OH Acrylic Acid(AA) -NH 2 Acrylamide (AM) -N(CH 3 ) 2 Dimethylacrylamide (DMA) -OCH 2 CH 2 OH 2-Hydroxyethylacrylate (HEA) -O(CH 2 CH 2 O) n CH 3 PEG monomethyoxylacrylate (PEG)

公开(公告)号：AU2003269873A1

公开(公告)日：2003-12-19

申请号：AU2003269873

申请日：2003-05-13

Applicant: UNIV CALIFORNIA

Inventor： ALLBRITTON NANCY ,  SIMS CHRISTOPHER E ,  HU SHUWEN ,  REN XUEGIN ,  LI GUANN-PYNG ,  BACHMAN MARK

IPC: C08J7/18 ,  G01N27/447 ,  G02B1/04 ,  G02C7/04

Abstract: Polymer-based biomaterials are popular due to ease of fabrication and low costs. However, many polymer substrates have undesirable surface properties. The invention provides a procedure to covalently apply a graft polymer to the surface of a polymer substrate by ultraviolet graft polymerization. The graft polymer is formed from monomers such as PEG, AA, monomethoxy acrylate PEG, HEMA, or DMA. Also, mixed monomers may be used to create the graft and the surface properties of the graft may be tailored for different properties, including hydrophobicity, friction coefficient, electroosmotic mobilities and electrophoretic separations. The invention has particular utility in tailoring surface chemistries in ocular lenses and polymer microdevices. I. II. R: -OH Acrylic Acid(AA) -NH 2 Acrylamide (AM) -N(CH 3 ) 2 Dimethylacrylamide (DMA) -OCH 2 CH 2 OH 2-Hydroxyethylacrylate (HEA) -O(CH 2 CH 2 O) n CH 3 PEG monomethyoxylacrylate (PEG)