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    FLEXIBLE SENSOR APPARATUS
    1.
    发明公开
    FLEXIBLE SENSOR APPARATUS 审中-公开

    公开(公告)号：EP3146534A4

    公开(公告)日：2018-04-18

    申请号：EP15795336

    申请日：2015-05-18

    Applicant: UNIV CALIFORNIA

    Inventor： PEGAN JONATHAN ,  KHINE MICHELLE ,  BACHMAN MARK ,  KIM JOSHUA ,  PARK SUN JUN

    IPC: H01B7/06 ,  G01L1/22

    CPC classification number: G01B7/20 ,  A61B5/113 ,  A61B2562/0261 ,  A61B2562/0285 ,  A61B2562/164 ,  G01L1/2287

    Abstract: A sensor apparatus including a flexible substrate and a wrinkled conductor disposed on the flexible substrate. In some embodiments, the conductor includes micro-scale invaginations. Also disclosed are methods of making a sensor apparatus, including: placing a mask over a polymeric sheet, wherein the mask is configured to block regions of the polymeric sheet, depositing a conductive structure on the polymeric sheet at regions exposed through the mask, shrinking the polymeric sheet with conductive structure patterned on its surface by heating, and transferring the conductive structure to a flexible substrate. Also disclosed are methods of sensing a health condition of a user or patient. The methods include coupling a sensor apparatus to a surface of a user or patient overlying structures to be monitored. The sensor apparatus may include a crumpled conductor capable of detecting strain. Strain is detected by directing current through the sensor apparatus during flexing of the surface and measuring a characteristic of the sensor apparatus based on the strain to generate an output for a user, indicative of the condition of the user or patient.

    A micro-bubble plate for patterning biological and non-biological materials
    5.
    发明专利
    A micro-bubble plate for patterning biological and non-biological materials 未知

    公开(公告)号：AU2006342231B2

    公开(公告)日：2012-04-19

    申请号：AU2006342231

    申请日：2006-10-10

    Applicant: UNIV CALIFORNIA

    Inventor： LI GUANN-PYNG ,  SIMS CHRISTOPHER ,  BACHMAN MARK ,  ALLBRITTON NANCY ,  WANG YULI

    IPC: B01L3/00 ,  C12M1/22

    Abstract: Systems and methods for patterning biological and non-biological material at specific sites on a plate, as well as growing three dimensional structures. Preferred embodiments comprise a plate with regions that will trap gas, usually in the form of bubbles, when the plate is submerged in liquid. Other embodiments of the present invention include a method for placing materials on the plate at predetermined locations through the use of trapped gas to prevent materials from collecting at unwanted regions. The plate has great utility for plating cells and tissues at specific sites, such as on an array. The disclosed method can also be used to coat the surface of a plate at specific locations for patterned coating applications and to build up materials to produce three dimensional structures, including micromechanical structures where the structures may be formed from living or nonliving material, organic or inorganic, and the like.

    A MICRO-BUBBLE PLATE FOR PATTERNING BIOLOGICAL AND NON-BIOLOGICAL MATERIALS
    6.
    发明申请
    A MICRO-BUBBLE PLATE FOR PATTERNING BIOLOGICAL AND NON-BIOLOGICAL MATERIALS 审中-公开
    用于绘制生物和非生物材料的微孔板

    公开(公告)号：WO2007120183A3

    公开(公告)日：2008-01-10

    申请号：PCT/US2006039929

    申请日：2006-10-10

    Applicant: UNIV CALIFORNIA ,  WANG YULI ,  BACHMAN MARK ,  SIMS CHRISTOPHER ,  LI GUANN-PYNG ,  ALLBRITTON NANCY

    Inventor： WANG YULI ,  BACHMAN MARK ,  SIMS CHRISTOPHER ,  LI GUANN-PYNG ,  ALLBRITTON NANCY

    IPC: C12M1/22 ,  B01L3/00

    CPC classification number: B01L3/5085 ,  B01L3/5088 ,  B01L2200/0642 ,  B01L2200/12 ,  B01L2300/0819 ,  C12M25/06 ,  C12M29/20

    Abstract: Systems and methods for patterning biological and non-biological material at specific sites on a plate, as well as growing three dimensional structures. Preferred embodiments comprise a plate (6) with regions (16) that will trap gas, usually in the form of bubbles (10), when the plate (6) is submerged in liquid. Other embodiments of the present invention include a method for placing materials on the plate (6) at predetermined locations through the use of trapped gas to prevent materials from collecting at unwante regions. The plate (6) has great utility for plating cells and tissues (5) at specific sites, such as on an array. The disclosed method can also be used to coat the surface of a plate (6) at specific locations for patterned coating applications and to build up materials to produce three dimensional structures, including micromechanical structures where the structures may be formed from living or nonliving material, organic or inorganic, and the like.

    Abstract translation: 用于在板上的特定位置图案化生物和非生物材料的系统和方法，以及生长三维结构。 优选实施例包括具有区域（16）的板（6），当板（6）浸没在液体中时，该板（6）将通常以气泡（10）的形式捕获气体。 本发明的其他实施例包括通过使用被捕获的气体将材料放置在板（6）上的预定位置处的方法，以防止材料在不透水区域收集。 板（6）对于在特定位置（例如阵列）上的电镀细胞和组织（5）具有很大的用途。 所公开的方法还可以用于在特定位置涂覆板（6）的表面用于图案化涂覆应用，并且建立材料以产生三维结构，包括微机械结构，其中结构可以由活的或非活性的材料形成， 有机或无机等。

    FAST ELECTRICAL LYSIS OF CELLS AND RAPID COLLECTION OF THE CONTENTS THEREOF USING CAPILLARY ELECTROPHORESIS
    7.
    发明申请
    FAST ELECTRICAL LYSIS OF CELLS AND RAPID COLLECTION OF THE CONTENTS THEREOF USING CAPILLARY ELECTROPHORESIS 审中-公开
    细胞的快速电学分析和快速收集其使用毛细管电泳的内容

    公开(公告)号：WO03093791A2

    公开(公告)日：2003-11-13

    申请号：PCT/US0313599

    申请日：2003-05-02

    Applicant: UNIV CALIFORNIA

    Inventor： ALBRITTON NANCY ,  LI GUANN-PYNG ,  BACHMAN MARK ,  SIMS CHRISTOPHER ,  HAN FUTIAN

    IPC: B01L3/00 ,  G01N27/447 ,  G01N33/50 ,  G01N33/559 ,  G01N33/561 ,  G01N

    CPC classification number: G01N33/561 ,  B01L3/5027 ,  C12M47/06 ,  G01N27/44743 ,  G01N33/5005 ,  G01N33/559

    Abstract: The invention provides apparatus and methods for subsecond lysis of selected cells (58) in a cell chamber (10) using a voltage pulse of 10 ms to 10 µs in duration followed by nearly simultaneous collection of the lysed cellular contents (59) into a capillary electrophoresis tube (42) or other suitable micro-collection device (15). Cell chambers (10) and capillary electrophoresis (42) tubes configured with electrodes (18, 19) for performing the electrical lysis are described. The influence of variables that govern the rate of cell lysis, such as the inter-electrode distance, pulse duration, and pulse strength are also described. The methods are illustrated using fluorophores that are loaded into a cell (10) and then collected following electrical lysis, separated by electrophoresis, and then detected by laser-induced fluorescence detection in a capillary electrophoresis system.

    Abstract translation: 本发明提供用于使用10ms至10μs持续时间的电压脉冲在细胞室（10）中亚细胞裂解所选择的细胞（58）的装置和方法，随后裂解的细胞内含物（59）几乎同时收集到毛细管 电泳管（42）或其他合适的微量收集装置（15）。 描述了配置有用于进行电裂解的电极（18,19）的细胞室（10）和毛细管电泳（42）管。 还描述了控制细胞裂解速率的变量的影响，例如电极间距离，脉冲持续时间和脉冲强度。 使用装载到细胞中的荧光团（10），然后在电裂解后收集，通过电泳分离，然后通过毛细管电泳系统中的激光诱导荧光检测来检测方法。

    VIBRATION DETECTORS, SOUND DETECTORS, HEARING AIDS, COCHLEAR IMPLANTS AND RELATED METHODS
    8.
    发明专利
    VIBRATION DETECTORS, SOUND DETECTORS, HEARING AIDS, COCHLEAR IMPLANTS AND RELATED METHODS 未知

    公开(公告)号：AU2003259941A1

    公开(公告)日：2004-03-11

    申请号：AU2003259941

    申请日：2003-08-20

    Applicant: UNIV CALIFORNIA

    Inventor： LI GUANN-PYNG ,  BACHMAN MARK ,  XU TAO ,  ZENG FAN-GANG ,  COFFEY PATRICK

    IPC: G01H9/00

    Abstract: A directionally-sensitive device for detecting and processing vibration waves includes an array of polymeric optical waveguide resonators positioned between a light source, such as an LED array, and a light detector, such as a photodiode array. The resonators which are preferably oriented substantially perpendicularly with respect to incoming vibration waves, vibrate when a wave is detected, thus modulating light signals that are transmitted between the light source and the light detector. The light detector converts the modulated light into electrical signals which, in a preferred embodiment, are used to drive either the speaker of a hearing aid or the electrode array of a cochlear implant. The device is manufactured using a combination of traditional semiconductor processes and polymer microfabrication techniques.

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