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公开(公告)号：AU2016218900A1
公开(公告)日：2017-08-24
申请号：AU2016218900
申请日：2016-02-11
Applicant: UNIV HEALTH NETWORK
Inventor： BLASER HEIKO , MAK TAK
IPC: C07K16/28 , A61K31/7088 , A61K39/395 , A61P35/04 , C12N15/113 , G01N33/53 , G01N33/574
Abstract: The present invention is directed to methods and compositions for modulating LILR for treatment of cancer and inhibition of metastasis.
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2.发明申请METHODS AND COMPOSITIONS FOR DETECTION OF TARGETS INVOLVED IN CANCER METASTASIS 审中-公开用于检测癌症参与的靶标的方法和组合物
公开(公告)号：WO2015132672A3
公开(公告)日：2015-12-17
申请号：PCT/IB2015000996
申请日：2015-03-06
Applicant: UNIV HEALTH NETWORK
Inventor： BLASER HEIKO , MAK TAK W
CPC classification number: C12Q1/6883 , A61K38/177 , A61K39/39541 , A61K39/39558 , A61K49/0008 , A61K2039/505 , A61K2039/507 , C07K14/70503 , C07K16/2818 , C07K2317/76 , C12N15/1135 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/5088 , G01N2333/82 , A61K2300/00
Abstract: The present application is directed to methods and compositions for identifying target nucleic acids that are involved in cancer metastasis. The method comprises transfecting an immortalized cell line with one or more target cDNAs, said transfected cells further expressing a detectable reporter gene. The immortalized cell line lacks metastatic potential in absence of the transfected target cDNAs. Upon injection of said transfected cells into an animal, tumor cells are imaged, isolated and analyzed with respect to the presence of said target cDNAs thus identifying a gene(s) that modulates tumor metastasis.
Abstract translation: 本申请涉及用于鉴定参与癌症转移的靶核酸的方法和组合物。 该方法包括用一种或多种靶cDNA转染永生化细胞系，所述转染细胞进一步表达可检测的报道基因。 在不存在转染的靶cDNA的情况下，永生化细胞系缺乏转移潜力。 在将所述转染的细胞注射到动物中后，相对于所述靶cDNA的存在，对肿瘤细胞进行成像，分离和分析，从而鉴定调节肿瘤转移的基因。
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公开(公告)号：CA2976130A1
公开(公告)日：2016-08-18
申请号：CA2976130
申请日：2016-02-11
Applicant: UNIV HEALTH NETWORK
Inventor： BLASER HEIKO , MAK TAK
IPC: A61K39/395 , A61K31/7088 , A61P35/04 , C07K16/28 , C12N15/113 , G01N33/53 , G01N33/574
Abstract: The present invention is directed to methods and compositions for modulating LILR for treatment of cancer and inhibition of metastasis.
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公开(公告)号：CA2941693A1
公开(公告)日：2015-09-11
申请号：CA2941693
申请日：2015-03-06
Applicant: UNIV HEALTH NETWORK
Inventor： BLASER HEIKO , MAK TAK W
Abstract: The present application is directed to methods and compositions for identifying target nucleic acids that are involved in cancer metastasis. The method comprises transfecting an immortalized cell line with one or more target cDNAs, said transfected cells further expressing a detectable reporter gene. The immortalized cell line lacks metastatic potential in absence of the transfected target cDNAs. Upon injection of said transfected cells into an animal, tumor cells are imaged, isolated and analyzed with respect to the presence of said target cDNAs thus identifying a gene(s) that modulates tumor metastasis.
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