公开(公告)号：CA3032249A1

公开(公告)日：2018-02-22

申请号：CA3032249

申请日：2017-08-17

Applicant: UNIV HEALTH NETWORK

Inventor： NGUYEN THUY-LINH ,  OHASHI PAMELA S ,  CROME SARAH

IPC: A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  G01N33/48

Abstract: There is described herein methods for improving tumor infiltrating lymphocyte (TIL) therapy by limiting the effect of innate lymphoid cells (ILCs) thereon. For example, in an aspect, there is provided a method of treating cancer in a patient in need thereof, comprising inhibiting the suppressive effect of CD56+CD3- innate lymphoid cells (ILCs) on tumor infiltrating lymphocyte (TIL) propagation or expansion.