公开(公告)号：CA3242099A1

公开(公告)日：2023-06-29

申请号：CA3242099

申请日：2022-12-21

Applicant: UNIV HEALTH NETWORK

Inventor： BRAY MARK R ,  MASON JACQUELINE M ,  WEI XIN ,  DUNCAN GORDON

IPC: A61K31/437 ,  A61P35/02 ,  C07D471/04

Abstract: The invention is related to a method of treating a subject with acute myeloid leukemia, acute lymphoblastic leukemia, non-Hodgkin's lymphoma, Burkitt lymphoma, or diffuse large B-cell lymphoma by administration of Compound (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：IL297314A

公开(公告)日：2022-12-01

申请号：IL29731422

申请日：2022-10-13

Applicant: UNIV HEALTH NETWORK ,  BRAY MARK R ,  MASON JACQUELINE M ,  WEI XIN ,  DUNCAN GORDON

Inventor： BRAY MARK R ,  MASON JACQUELINE M ,  WEI XIN ,  DUNCAN GORDON

IPC: A61K31/4365 ,  A61K31/496 ,  A61P37/02

Abstract: Disclosed herein is a method of treating a subject with aberrant cytokine release from a disease or condition or at risk of developing aberrant cytokine release from a disease or condition. The method comprises administering to the subject an effective amount of a compound represented by structural formula (I): (I) or a pharmaceutically acceptable salt thereof. The variables in structural formula (I) are as described herein.

公开(公告)号：AU2021257439A1

公开(公告)日：2022-12-15

申请号：AU2021257439

申请日：2021-04-12

Applicant: UNIV HEALTH NETWORK

Inventor： BRAY MARK R ,  MASON JACQUELINE M ,  WEI XIN ,  DUNCAN GORDON

IPC: A61P37/02 ,  A61K31/4436 ,  C07D495/04

Abstract: Disclosed herein is a method of treating a subject with aberrant cytokine release from a disease or condition or at risk of developing aberrant cytokine release from a disease or condition. The method comprises administering to the subject an effective amount of a compound represented by structural formula (I): (I) or a pharmaceutically acceptable salt thereof. The variables in structural formula (I) are as described herein.