公开(公告)号：EP3057593A4

公开(公告)日：2017-03-08

申请号：EP14853347

申请日：2014-10-03

Applicant: UNIV HEALTH NETWORK

Inventor： HEDLEY DAVID W ,  LOHSE INES ,  MASON JACQUELINE M ,  BRAY MARK R

IPC: A61K31/5377 ,  A61K31/416 ,  A61P35/00

CPC classification number: A61K31/5377 ,  A61K31/7068 ,  A61K33/24 ,  A61K45/06 ,  C07D403/08 ,  C07D413/14 ,  A61K2300/00

公开(公告)号：AU2018328773B2

公开(公告)日：2023-11-16

申请号：AU2018328773

申请日：2018-09-07

Applicant: UNIV HEALTH NETWORK

Inventor： MASON JACQUELINE M ,  BRAY MARK R ,  MAK TAK WAH ,  FLETCHER GRAHAM

IPC: C07D413/10 ,  A61K31/5377 ,  A61K39/395 ,  A61P35/00

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula (Formula (I)) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

公开(公告)号：AU2014336917A1

公开(公告)日：2016-05-05

申请号：AU2014336917

申请日：2014-10-03

Applicant: UNIV HEALTH NETWORK

Inventor： HEDLEY DAVID W ,  LOHSE INES ,  MASON JACQUELINE M ,  BRAY MARK R

IPC: C07D413/14 ,  A61K31/416 ,  A61K31/5377 ,  A61P35/00

Abstract: The invention is related to a method of treating a subject with pancreatic cancer with administration of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof.

公开(公告)号：CA2927612A1

公开(公告)日：2015-04-23

申请号：CA2927612

申请日：2014-10-03

Applicant: UNIV HEALTH NETWORK

Inventor： HEDLEY DAVID W ,  LOHSE INES ,  MASON JACQUELINE M ,  BRAY MARK R

IPC: A61K31/5377 ,  A61K31/416 ,  A61P35/00 ,  C07D413/14

Abstract: The invention is related to a method of treating a subject with pancreatic cancer with administration of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP3212652A4

公开(公告)日：2018-04-25

申请号：EP15855932

申请日：2015-10-09

Applicant: UNIV HEALTH NETWORK

Inventor： LAUFER RADOSLAW ,  NG GRACE ,  BROKX RICHARD ,  PAULS HEINZ W ,  LI SZE-WAN ,  MASON JACQUELINE M ,  BRAY MARK R

IPC: C07D487/04 ,  A61K31/519 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06

CPC classification number: A61K31/519 ,  A61K45/06 ,  C07D487/04

Abstract: The invention is a compound represented by Structural Formula (I): (I); or a pharmaceutically acceptable salt thereof. Values for the variables are provided herein. Also included is a pharmaceutical composition comprising the compound represented by Structural Formula (I) and a pharmaceutically acceptable carrier or diluent and methods of treating a subject with cancer with the compound of Structural Formula (I).

公开(公告)号：CA3242099A1

公开(公告)日：2023-06-29

申请号：CA3242099

申请日：2022-12-21

Applicant: UNIV HEALTH NETWORK

Inventor： BRAY MARK R ,  MASON JACQUELINE M ,  WEI XIN ,  DUNCAN GORDON

IPC: A61K31/437 ,  A61P35/02 ,  C07D471/04

Abstract: The invention is related to a method of treating a subject with acute myeloid leukemia, acute lymphoblastic leukemia, non-Hodgkin's lymphoma, Burkitt lymphoma, or diffuse large B-cell lymphoma by administration of Compound (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：CA2927612C

公开(公告)日：2022-08-30

申请号：CA2927612

申请日：2014-10-03

Applicant: UNIV HEALTH NETWORK

Inventor： HEDLEY DAVID W ,  LOHSE INES ,  MASON JACQUELINE M ,  BRAY MARK R

IPC: A61K31/5377 ,  A61K31/416 ,  A61P35/00 ,  C07D413/14

Abstract: The invention is related to a method of treating a subject with pancreatic cancer with administration of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof.

公开(公告)号：AU2020234533A1

公开(公告)日：2021-09-16

申请号：AU2020234533

申请日：2020-03-11

Applicant: UNIV HEALTH NETWORK

Inventor： BROKX RICHARD ,  MASON JACQUELINE M ,  BRAY MARK R

IPC: C07K16/18 ,  A61K39/395 ,  C12N15/13 ,  C12P21/08

Abstract: The invention provides novel anti-TSG-6 antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.

公开(公告)号：CA3130225A1

公开(公告)日：2020-08-20

申请号：CA3130225

申请日：2020-02-14

Applicant: UNIV HEALTH NETWORK

Inventor： BROKX RICHARD ,  MASON JACQUELINE M ,  BRAY MARK R

IPC: C07K16/28 ,  A61K39/395 ,  A61P31/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  C12N5/10 ,  C12N15/13 ,  C12P21/08

Abstract: The invention provides novel anti-FCMR antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.

公开(公告)号：IL297314A

公开(公告)日：2022-12-01

申请号：IL29731422

申请日：2022-10-13

Applicant: UNIV HEALTH NETWORK ,  BRAY MARK R ,  MASON JACQUELINE M ,  WEI XIN ,  DUNCAN GORDON

Inventor： BRAY MARK R ,  MASON JACQUELINE M ,  WEI XIN ,  DUNCAN GORDON

IPC: A61K31/4365 ,  A61K31/496 ,  A61P37/02

Abstract: Disclosed herein is a method of treating a subject with aberrant cytokine release from a disease or condition or at risk of developing aberrant cytokine release from a disease or condition. The method comprises administering to the subject an effective amount of a compound represented by structural formula (I): (I) or a pharmaceutically acceptable salt thereof. The variables in structural formula (I) are as described herein.