公开(公告)号：CA3101021A1

公开(公告)日：2019-12-05

申请号：CA3101021

申请日：2019-05-30

Applicant: UNIV HEALTH NETWORK

Inventor： NOSTRO MARIA CRISTINA ,  SARANGI FARIDA ,  KORYTNIKOV ROMAN ,  MCGAUGH EMILY ,  POON FRANKIE HOI CHUN

IPC: A61K35/39 ,  A61P3/10 ,  C12N5/071

Abstract: Methods and compositions are provided for producing PDX1+/NKX6-1+ pancreatic progenitor cells from a PDX1+ endodermal cell population. The method comprises contacting the endodermal cell population with an EGF component and tankyrase inhibitor that binds to an adenosine subsite of a tankyrase enzyme, to induce the differentiation of at least a portion of the PDX1+ endodermal cell population into PDX1+NKX6-1+ pancreatic progenitor cells.