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公开(公告)号：WO2013172708A8
公开(公告)日：2014-05-30
申请号：PCT/NL2013050357
申请日：2013-05-14
Applicant: UNIV TWENTE
Inventor： VERSLUIS ANDREAS MICHAEL , SEGERS TIM JOSEPH
CPC classification number: A61K49/223 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2400/0439 , B01L2400/0487 , B01L2400/0496 , G01N15/0255 , G01N2015/0288 , G01N2015/142 , G01N2015/149
Abstract: Disclosed is a continuous method of size-sorting microbubbles, comprising: providing a polydisperse plurality of microbubbles (70); entraining said microbubbles (70) in a fluid flow (46) flowing in a flow direction (x+) towards a collection location (62); at an insonification location (60) upstream of the collection location (62), subjecting the microbubbles (70) in said fluid flow (46) to an acoustic pressure wave (52) propagating in a wave direction with a non-zero directional component in a microbubble segregation dimension (y) that extends perpendicular to the flow direction (x+), thereby segregating microbubbles of different equilibrium radius (ro) in said microbubble segregation dimension (y) as they pass the insonification location; and at said collection location (62), collecting the microbubbles (70) present within at least two spatial ranges (44a-c) of said microbubble segregation dimension (y). Also disclosed is an apparatus (1) implementing the method.
Abstract translation: 公开了一种连续的尺寸分选微泡的方法，包括：提供多分散的多个微泡（70）; 在流向（x +）朝向收集位置（62）流动的流体流（46）中夹带所述微泡（70）; 在收集位置（62）上游的增音位置（60）处，使所述流体流（46）中的微泡（70）经受在波方向上以非零方向分量传播的声压波（52） 所述微气泡分离尺寸（y）垂直于所述流动方向（x +）延伸，从而在所述微泡偏析尺寸（y）中通过所述微泡位置时分离不同平衡半径（ro）的微泡; 并且在所述收集位置（62）处收集存在于所述微泡分离尺寸（y）的至少两个空间范围（44a-c）内的微泡（70）。 还公开了实现该方法的装置（1）。
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公开(公告)号：NL2008816C
公开(公告)日：2013-11-18
申请号：NL2008816
申请日：2012-05-14
Applicant: UNIV TWENTE
Inventor： VERSLUIS ANDREAS MICHAEL , SEGERS TIM JOSEPH
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公开(公告)号：NL2008816C2
公开(公告)日：2013-11-18
申请号：NL2008816
申请日：2012-05-14
Applicant: UNIV TWENTE
Inventor： VERSLUIS ANDREAS MICHAEL , SEGERS TIM JOSEPH
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