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公开(公告)号：WO2013172708A8
公开(公告)日：2014-05-30
申请号：PCT/NL2013050357
申请日：2013-05-14
Applicant: UNIV TWENTE
Inventor： VERSLUIS ANDREAS MICHAEL , SEGERS TIM JOSEPH
CPC classification number: A61K49/223 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2400/0439 , B01L2400/0487 , B01L2400/0496 , G01N15/0255 , G01N2015/0288 , G01N2015/142 , G01N2015/149
Abstract: Disclosed is a continuous method of size-sorting microbubbles, comprising: providing a polydisperse plurality of microbubbles (70); entraining said microbubbles (70) in a fluid flow (46) flowing in a flow direction (x+) towards a collection location (62); at an insonification location (60) upstream of the collection location (62), subjecting the microbubbles (70) in said fluid flow (46) to an acoustic pressure wave (52) propagating in a wave direction with a non-zero directional component in a microbubble segregation dimension (y) that extends perpendicular to the flow direction (x+), thereby segregating microbubbles of different equilibrium radius (ro) in said microbubble segregation dimension (y) as they pass the insonification location; and at said collection location (62), collecting the microbubbles (70) present within at least two spatial ranges (44a-c) of said microbubble segregation dimension (y). Also disclosed is an apparatus (1) implementing the method.
Abstract translation: 公开了一种连续的尺寸分选微泡的方法，包括：提供多分散的多个微泡（70）; 在流向（x +）朝向收集位置（62）流动的流体流（46）中夹带所述微泡（70）; 在收集位置（62）上游的增音位置（60）处，使所述流体流（46）中的微泡（70）经受在波方向上以非零方向分量传播的声压波（52） 所述微气泡分离尺寸（y）垂直于所述流动方向（x +）延伸，从而在所述微泡偏析尺寸（y）中通过所述微泡位置时分离不同平衡半径（ro）的微泡; 并且在所述收集位置（62）处收集存在于所述微泡分离尺寸（y）的至少两个空间范围（44a-c）内的微泡（70）。 还公开了实现该方法的装置（1）。
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2.发明申请
公开(公告)号：WO2013141695A8
公开(公告)日：2014-10-16
申请号：PCT/NL2012050179
申请日：2012-03-22
Applicant: UNIV TWENTE , UNIV SEVILLA , VAN HOEVE WILLEM , DE CASTRO HERNÁNDEZ ELENA , GORDILLO ARIAS DE SAVEEDRA JOSÉ MANUEL , VERSLUIS ANDREAS MICHAEL , LOHSE DETLOF
Inventor： VAN HOEVE WILLEM , DE CASTRO HERNÁNDEZ ELENA , GORDILLO ARIAS DE SAVEEDRA JOSÉ MANUEL , VERSLUIS ANDREAS MICHAEL , LOHSE DETLOF
CPC classification number: B01F5/0602 , A61K49/223 , B01F3/0446 , B01F3/04985 , B01F13/0062 , B01F13/0064 , B01F13/0084 , B01F13/0086 , B01F2003/04858 , B01F2005/0097 , B01F2215/0034 , B01J19/0093 , B01J2219/0084 , B01J2219/0086 , B01J2219/00894 , B01J2219/00959 , B01J2219/00995
Abstract: An apparatus (1) for mass producing monodisperse microbubbles, comprising a microfluidic flow focusing device (2) including a dispersed phase fluid supply channel (110) having an outlet (114) that discharges into a flow focusing junction (140); a continuous phase fluid supply channel (120, 120') having an outlet (124) that discharges into the flow focusing junction; and a bubble formation channel (130) having an inlet (132) disposed at the flow focusing junction. The configuration of the flow focusing junction (140) is such that, in operation, a flow of dispersed phase fluid (12) discharging from the outlet (114) of the dispersed phase fluid supply channel (110) is engageable in co-flow by a focusing flow of continuous phase fluid discharging from the outlet of the at least one continuous phase fluid supply channel under formation of a gradually thinning jet of dispersed phase fluid that extends into the inlet of the bubble formation channel.
Abstract translation: 一种用于批量生产单分散微泡的装置（1），包括微流体聚焦装置（2），该微流体聚焦装置包括分散相流体供应通道（110），该分散相流体供应通道具有排出流入聚焦结（140）的出口（114）。 连续相流体供应通道（120,120'）具有排出到流动聚焦结的出口（124）; 和具有设置在流动聚焦结处的入口（132）的气泡形成通道（130）。 流动聚焦结（140）的构造使得在操作中，从分散相流体供应通道（110）的出口（114）排出的分散相流体（12）的流动可通过 在至少一个连续相流体供应通道的出口处的连续相流体的聚焦流动形成逐渐变薄的分散相流体的喷射，其延伸到气泡形成通道的入口。
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公开(公告)号：NL2008816C
公开(公告)日：2013-11-18
申请号：NL2008816
申请日：2012-05-14
Applicant: UNIV TWENTE
Inventor： VERSLUIS ANDREAS MICHAEL , SEGERS TIM JOSEPH
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公开(公告)号：NL2008816C2
公开(公告)日：2013-11-18
申请号：NL2008816
申请日：2012-05-14
Applicant: UNIV TWENTE
Inventor： VERSLUIS ANDREAS MICHAEL , SEGERS TIM JOSEPH
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