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1.发明申请CARDIAC VISUALIZATION SYSTEMS FOR DISPLAYING 3-D IMAGES OF CARDIAC VOXEL INTENSITY DISTRIBUTIONS WITH OPTIONAL PHYSICIAN INTERACTIVE BOUNDARY TRACING TOOLS 审中-公开用于显示具有可选物理交互式边界跟踪工具的心脏瓣膜强度分布的三维图像的心脏可视化系统
公开(公告)号：WO2007092159A3
公开(公告)日：2008-03-20
申请号：PCT/US2007001927
申请日：2007-01-25
Applicant: UNIV WAKE FOREST HEALTH SCIENCES , HUNDLEY WILLIAM GREGORY , HAMILTON CRAIG A , D AGOSTINO RALPH B
Inventor： HUNDLEY WILLIAM GREGORY , HAMILTON CRAIG A , D AGOSTINO RALPH B
CPC classification number: G06T7/0012 , A61B5/0044 , A61B5/055 , A61B5/7285 , A61B6/466 , A61B6/503 , A61B6/504 , A61B6/506 , A61B6/541 , G01R33/283 , G01R33/546 , G06T2207/10088 , G06T2207/20104 , G06T2207/30048 , Y10S128/92 , Y10S128/921 , Y10S128/922 , Y10S128/923 , Y10S128/924
Abstract: Physician interactive workstations with global cardiac voxel distribution visualization may also include one or more of a 3-D color scale image of a population of voxel in the heart and/or an electronic boundary-tracing tool configured to accept user input to electronically define at least one boundary of a target region of a heart in a medical image of a patient on a display. The workstation may be configured to evaluate intensity of voxels associated with tissue within the defined boundary of the target region of the heart whereby cardiotoxicity is evaluated.
Abstract translation: 具有全球心脏体素分布可视化的医师交互式工作站还可以包括心脏中的体素群体的3-D色标图像中的一个或多个，和/或配置成接受用户输入至少以电子方式定义的电子边界跟踪工具 在显示器上患者的医学图像中的心脏的目标区域的一个边界。 工作站可以被配置为评估与心脏的目标区域的限定边界内的组织相关联的体素的强度，其中评估心脏毒性。
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2.发明申请SYSTEMS AND METHODS FOR THE DETERMINATION OF CARDIAC INJURY USING A CHARACTERIZING PORTION OF A VOXEL HISTOGRAM 审中-公开使用VOXEL HISTOGRAM的表征部分确定心脏损伤的系统和方法
公开(公告)号：WO2007092115A3
公开(公告)日：2007-12-13
申请号：PCT/US2007000603
申请日：2007-01-10
Applicant: UNIV WAKE FOREST HEALTH SCIENCES , HUNDLEY WILLIAM GREGORY , HAMILTON CRAIG A , LANE KIMBERLY , MORGAN TIM , TORTI FRANK , D AGOSTINO RALPH B
Inventor： HUNDLEY WILLIAM GREGORY , HAMILTON CRAIG A , LANE KIMBERLY , MORGAN TIM , TORTI FRANK , D AGOSTINO RALPH B
CPC classification number: A61B5/055 , A61B6/506 , G06K9/6212 , G06K2209/05 , G06T7/0012 , G06T2207/10088 , G06T2207/10096 , G06T2207/30048
Abstract: Methods, systems and circuits predict cardiotoxicity induced cardiac injury prior to an irreversible state by electronically generating at least one histogram of mean intensities of voxels/pixels in an MRI image of a left ventricle myocardium and electronically determining a likelihood of cardiac injury due to cardiotoxicity based on data from the at least one histogram.
Abstract translation: 方法，系统和电路通过电子地生成左心室心肌的MRI图像中的至少一个体素/像素的平均强度的直方图来预测在不可逆状态之前引起的心脏损伤的心脏毒性，并且电子地确定由于心脏毒性引起的心脏损伤的可能性 来自至少一个直方图的数据。
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公开(公告)号：WO2005077263A3
公开(公告)日：2007-03-29
申请号：PCT/US2005003763
申请日：2005-02-04
Applicant: UNIV WAKE FOREST HEALTH SCIENCES , HUNDLEY WILLIAM GREGORY , HAMILTON CRAIG A , LANE KIMBERLY , MORGAN TIM , TORTI FRANK
Inventor： HUNDLEY WILLIAM GREGORY , HAMILTON CRAIG A , LANE KIMBERLY , MORGAN TIM , TORTI FRANK
CPC classification number: A61B5/0033 , A61B5/055 , A61B5/42 , A61B5/4519 , A61B6/032 , A61B6/503 , A61B6/504 , A61B6/506 , G01R33/281 , G01R33/56 , G06T7/0014 , G06T7/41 , G06T2200/24 , G06T2207/10088 , G06T2207/30048
Abstract: Evaluating tissue characteristics including identification of injured tissue is provided by obtaining a first image of tissue including a region of interest from a first acquisition, for example, after administration of a contrast agent and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition, for example, after administration of a contrast agent. A global characteristic of the region of interest of the first image and of the second image is determined to allow a comparison of the global characteristic of the first image and the second image to determine a potential for a change in global tissue characteristics. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.
Abstract translation: 通过从施用造影剂获得包含感兴趣区域的组织的第一图像从第一次采集获得包括感兴趣区域的组织的第二图像，从而提供组织特征，包括识别受损组织。 第二次，随后的采集，例如在施用造影剂之后。 确定第一图像和第二图像的感兴趣区域的全局特征，以允许比较第一图像和第二图像的全局特征，以确定全局组织特征变化的可能性。 这种比较可以包括平均值，平均特征，直方图形状（例如偏斜和峰度）或直方图内的强度分布的比较。
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公开(公告)号：AU2005212310C1
公开(公告)日：2011-04-07
申请号：AU2005212310
申请日：2005-02-04
Applicant: UNIV WAKE FOREST HEALTH SCIENCES
Inventor： MORGAN TIM , TORTI FRANK , HAMILTON CRAIG A , HUNDLEY WILLIAM GREGORY , LANE KIMBERLY
Abstract: Evaluating tissue characteristics including identification of injured tissue is provided by obtaining a first image of tissue including a region of interest from a first acquisition, for example, after administration of a contrast agent, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition, for example, after administration of a contrast agent. A global characteristic of the region of interest of the first image and of the second image is determined to allow a comparison of the global characteristic of the first image and the second image to determine a potential for a change in global tissue characteristics. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.
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公开(公告)号：AU2005212310A1
公开(公告)日：2005-08-25
申请号：AU2005212310
申请日：2005-02-04
Applicant: UNIV WAKE FOREST HEALTH SCIENCES
Inventor： MORGAN TIM , TORTI FRANK , HAMILTON CRAIG A , HUNDLEY WILLIAM GREGORY , LANE KIMBERLY
Abstract: Evaluating tissue characteristics including identification of injured tissue is provided by obtaining a first image of tissue including a region of interest from a first acquisition, for example, after administration of a contrast agent, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition, for example, after administration of a contrast agent. A global characteristic of the region of interest of the first image and of the second image is determined to allow a comparison of the global characteristic of the first image and the second image to determine a potential for a change in global tissue characteristics. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.
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Patent Agency Ranking6.发明公开AUTOMATED RENAL EVALUATION SYSTEMS AND METHODS USING MRI IMAGE DATA 审中-公开AUTOMATED肾评估系统和方法使用MRI图像数据
公开(公告)号：EP2765908A4
公开(公告)日：2015-10-07
申请号：EP12839542
申请日：2012-10-10
Applicant: UNIV WAKE FOREST HEALTH SCIENCES
Inventor： HAMILTON CRAIG ALAN , HUNDLEY WILLIAM GREGORY , EDWARDS MATTHEW STEVENS , ROCCO MICHAEL VITO
IPC: A61B5/026 , A61B5/01 , A61B5/055 , A61B5/145 , A61B5/20 , G01R33/50 , G01R33/56 , G01R33/563 , G06T7/00
CPC classification number: A61B5/004 , A61B5/015 , A61B5/0263 , A61B5/055 , A61B5/14542 , A61B5/201 , A61B5/4848 , A61B5/4872 , A61M5/14 , G01R33/50 , G01R33/5601 , G01R33/5608 , G01R33/5635 , G01R33/56366
Abstract: Renal screening systems include a circuit configured to electronically analyze MRI image data of a subject to evaluate renal function and generate a renal-risk report for a plurality of different therapeutic agents based on renal responses to test doses of each of the agents.
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公开(公告)号：CA2555373C
公开(公告)日：2014-04-29
申请号：CA2555373
申请日：2005-02-04
Applicant: UNIV WAKE FOREST HEALTH SCIENCES
Inventor： HUNDLEY WILLIAM GREGORY , HAMILTON CRAIG A , LANE KIMBERLY , MORGAN TIM , TORTI FRANK
Abstract: Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, for example, after administration of a contrast agent to the patient, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition, for example, after administration of a contrast agent to the patient. The subsequent acquisition may be obtained after a period of time to determine if injury has occurred during that period of time. The region of interest may include heart, blood, muscle, brain, nerve, skeletal, skeletal muscle, liver, kidney, lung, pancreas, endocrine, gastrointestinal and/or genitourinary tissue. A global characteristic of the region of interest of the first image and of the second image is determined to allow a comparison of the global characteristic of the first image and the second image to determine a potential for a change in global tissue characteristics. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.
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公开(公告)号：CA2846978A1
公开(公告)日：2013-04-18
申请号：CA2846978
申请日：2012-10-10
Applicant: UNIV WAKE FOREST HEALTH SCIENCES
Inventor： HAMILTON CRAIG ALAN , HUNDLEY WILLIAM GREGORY , EDWARDS MATTHEW STEVENS , ROCCO MICHAEL VITO
Abstract: Renal screening systems include a circuit configured to electronically analyze MRI image data of a subject to evaluate renal function and generate a renal-risk report for a plurality of different therapeutic agents based on renal responses to test doses of each of the agents.
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公开(公告)号：AU2005212310B2
公开(公告)日：2010-11-18
申请号：AU2005212310
申请日：2005-02-04
Applicant: UNIV WAKE FOREST HEALTH SCIENCES
Inventor： MORGAN TIM , TORTI FRANK , HAMILTON CRAIG A , HUNDLEY WILLIAM GREGORY , LANE KIMBERLY
Abstract: Evaluating tissue characteristics including identification of injured tissue is provided by obtaining a first image of tissue including a region of interest from a first acquisition, for example, after administration of a contrast agent, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition, for example, after administration of a contrast agent. A global characteristic of the region of interest of the first image and of the second image is determined to allow a comparison of the global characteristic of the first image and the second image to determine a potential for a change in global tissue characteristics. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.
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公开(公告)号：CA2555373A1
公开(公告)日：2005-08-25
申请号：CA2555373
申请日：2005-02-04
Applicant: UNIV WAKE FOREST HEALTH SCIENCES
Inventor： HUNDLEY WILLIAM GREGORY , HAMILTON CRAIG A , TORTI FRANK , LANE KIMBERLY , MORGAN TIM
Abstract: Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, for example, after administrati on of a contrast agent to the patient, and obtaining a second image of the tiss ue including the region of interest during a second, subsequent acquisition, fo r example, after administration of a contrast agent to the patient. The subsequent acquisition may be obtained after a period of time to determine i f injury has occurred during that period of time. The region of interest may include heart, blood, muscle, brain, nerve, skeletal, skeletal muscle, liver , kidney, lung, pancreas, endocrine, gastrointestinal and/or genitourinary tissue. A global characteristic of the region of interest of the first image and of the second image is determined to allow a comparison of the global characteristic ofthe first image and the second image to determine a potential for a change in global tissue characteristics. Such a comparison m ay include comparison of mean, average characteristics, histogram shape, such a s skew and kurtosis, or distribution of intensities within the histogram.
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