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    HIGH THROUGHPUT OPTICAL SCANNER
    1.
    发明公开
    HIGH THROUGHPUT OPTICAL SCANNER 审中-公开
    OPTISCHE ABTASTEINRICHTUNG麻省理工HOHEM DURCHSATZ

    公开(公告)号：EP1036371A4

    公开(公告)日：2003-01-08

    申请号：EP98958648

    申请日：1998-11-19

    Applicant: UNIV WASHINGTON

    Inventor： BASIJI DAVID A ,  VAN DER ENGH GERRIT J ,  ESPOSITO RICHARD J

    IPC: G01N21/64 ,  G01J3/443 ,  G01J3/45 ,  G01N27/447 ,  G02B26/10 ,  G06K7/10 ,  G06T1/00 ,  H04N1/113 ,  G01B9/02 ,  G02B26/12 ,  G03C8/32

    CPC classification number: G01J3/443 ,  G01J3/45 ,  G06K7/10801

    Abstract: The present invention provides a scanning apparatus to obtain automated, rapid and sensitive scanning of substrate fluorescence, optical density or phosphorescence. The scanner uses a constant path length optical train, which enables the combination of a moving beam for high speed scanning with phase-sensitive detection for noise reduction. The constant path length optical train comprises a light source, a scanning mirror (40) to receive light from the light source and sweep it across a steering mirror (50), the steering mirror receives the light from the scanning mirror and reflect the light to a substrate wherein the substrate reflects the light to a photodetector (70).

    Abstract translation: 提供扫描装置以获得对衬底荧光，光密度或磷光的自动，快速和灵敏的扫描。 扫描仪使用恒定路径长度的光学列车，其能够将用于高速扫描的移动光束与用于降噪的相敏检测组合，包括光源，用于接收来自光源的光并扫描其的扫描镜 导向镜，转向镜，用于接收来自扫描反射镜的光并将其反射到基板，从而沿着扫描弧扫过基板;以及光电检测器，用于接收来自基板的发射或散射的光，其中光路 在整个扫描过程中，从光源到光电检测器的长度基本恒定。 光学系统还可以包括波导或反射镜以收集来自衬底的发射或散射的光并将其引导到光电探测器。 对于相敏检测，光源进行强度调制，检测器与相敏检测电路连接。 还提供了使用基板转换器的扫描仪。 对于二维成像，衬底在一个维度上平移，而扫描镜在第二维度扫描光束。 对于高通量扫描仪，将堆叠的基板从托盘进料器装载到传送带上。

    SYSTEM FOR SENSING DROPLET FORMATION TIME DELAY IN A FLOW CYTOMETER
    3.
    发明专利
    SYSTEM FOR SENSING DROPLET FORMATION TIME DELAY IN A FLOW CYTOMETER 未知

    公开(公告)号：CA2201331A1

    公开(公告)日：1996-04-25

    申请号：CA2201331

    申请日：1995-10-13

    Applicant: UNIV WASHINGTON

    Inventor： ESPOSITO RICHARD J ,  VAN DEN ENGH GER

    IPC: G01N15/10

    Abstract: A droplet flow cytometer system which includes a system to optimize the droplet formation time delay based on conditions actually experienced includes an automatic droplet sample (73) which rapidly moves a plurality of containers (75) stepwise through the droplet stream while simultaneously adjusting the droplet time delay. Through the system sampling of an actual substance to be processed can be used to minimize the effect of the substances variations or the determination of which time delay is optimal. Analysis such as cell counting and the like may be conducted manually or automatically and input to a time delay adjustement which may then act with analysis equipement to revise the time delay estimate actually applied during processing. The automatic sample (73) can be controlled through a microprocessor and approriate programming to bracket an inital droplet formation time delay estimate. When maximization counts through volume, weight, or other types of analysis exists in the containers, the increment may then be reduced for a more accurate ultimate setting. This may be accomplished while actually processing the sample without interruption.

    SYSTEM FOR SENSING DROPLET FORMATION TIME DELAY IN A FLOW CYTOMETER
    4.
    发明专利
    SYSTEM FOR SENSING DROPLET FORMATION TIME DELAY IN A FLOW CYTOMETER 未知

    公开(公告)号：CA2201331C

    公开(公告)日：2006-07-04

    申请号：CA2201331

    申请日：1995-10-13

    Applicant: UNIV WASHINGTON

    Inventor： VAN DEN ENGH GER ,  ESPOSITO RICHARD J

    IPC: G01N15/14 ,  G01N15/10

    Abstract: A droplet flow cytometer system which includes a system to optimize the droplet formation time delay based on conditions actually experienced includes an automatic droplet sample (75) which rapidly moves a plurality of containers (75) stepwise through the droplet stream while simultaneously adjusting the droplet time delay. Through the system sampling of an actual substance to be processed can be used to minimize the effect of the substances variations or the determination of which time delay is optimal. Analysis such as cell counting and the like may be conducted manually or automatically and input to a time delay adjustement which may then act with analysis equipement to revise the time delay estimate actually applied during processing. The automatic sample (73) can be controlled through a microprocessor and approriate programming to bracket an inital droplet formation time delay estimate. When maximization counts through volume, weight, or other types of analysis exists in the containers, the increment may then be reduced for a more accurate ultimate setting. This may be accomplished while actually processing the sample without interruption.

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