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公开(公告)号：US11723529B2
公开(公告)日：2023-08-15
申请号：US17882682
申请日：2022-08-08
Applicant: University of Houston System
Inventor： Kirill V. Larin , Achuth Nair , Manmohan Singh , Salavat Aglyamov
CPC classification number: A61B3/0025 , A61B3/102 , A61B3/16 , A61B3/165 , A61B5/0051 , A61B5/0053 , A61B5/0066 , A61B5/0093 , A61B8/10 , A61B8/485 , A61B5/0097 , A61B2576/00
Abstract: A system and method for measuring biomechanical properties of tissues without external excitation are capable of measuring and quantifying these parameters of tissues in situ and in vivo. The system and method preferably utilize a phase-sensitive optical coherence tomography (OCT) system for measuring the displacement caused by the intrinsic heartbeat. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. Preferably, the method is used to detect tissue stiffness and to evaluate its stiffness due to intrinsic pulsatile motion from the heartbeat. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases and evaluating the efficacy of therapies.
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公开(公告)号：US20220386862A1
公开(公告)日：2022-12-08
申请号：US17882682
申请日：2022-08-08
Applicant: University of Houston System
Inventor： Kirill V. Larin , Achuth Nair , Manmohan Singh , Salavat Aglyamov
Abstract: A system and method for measuring biomechanical properties of tissues without external excitation are capable of measuring and quantifying these parameters of tissues in situ and in vivo. The system and method preferably utilize a phase-sensitive optical coherence tomography (OCT) system for measuring the displacement caused by the intrinsic heartbeat. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. Preferably, the method is used to detect tissue stiffness and to evaluate its stiffness due to intrinsic pulsatile motion from the heartbeat. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases and evaluating the efficacy of therapies.
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3.发明申请公开(公告)号：US20200329958A1
公开(公告)日：2020-10-22
申请号：US16907424
申请日：2020-06-22
Applicant: University of Houston System
Inventor： Kirill V. Larin , Achuth Nair , Manmohan Singh , Salavat Aglyamov
Abstract: A system and method for measuring biomechanical properties of tissues without external excitation are capable of measuring and quantifying these parameters of tissues in situ and in vivo. The system and method preferably utilize a phase-sensitive optical coherence tomography (OCT) system for measuring the displacement caused by the intrinsic heartbeat. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. Preferably, the method is used to detect tissue stiffness and to evaluate its stiffness due to intrinsic pulsatile motion from the heartbeat. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases and evaluating the efficacy of therapies.
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公开(公告)号：US11406258B2
公开(公告)日：2022-08-09
申请号：US16907424
申请日：2020-06-22
Applicant: University of Houston System
Inventor： Kirill V. Larin , Achuth Nair , Manmohan Singh , Salavat Aglyamov
Abstract: A system and method for measuring biomechanical properties of tissues without external excitation are capable of measuring and quantifying these parameters of tissues in situ and in vivo. The system and method preferably utilize a phase-sensitive optical coherence tomography (OCT) system for measuring the displacement caused by the intrinsic heartbeat. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. Preferably, the method is used to detect tissue stiffness and to evaluate its stiffness due to intrinsic pulsatile motion from the heartbeat. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases and evaluating the efficacy of therapies.
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