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1.发明申请公开(公告)号：US20200329958A1
公开(公告)日：2020-10-22
申请号：US16907424
申请日：2020-06-22
Applicant: University of Houston System
Inventor： Kirill V. Larin , Achuth Nair , Manmohan Singh , Salavat Aglyamov
Abstract: A system and method for measuring biomechanical properties of tissues without external excitation are capable of measuring and quantifying these parameters of tissues in situ and in vivo. The system and method preferably utilize a phase-sensitive optical coherence tomography (OCT) system for measuring the displacement caused by the intrinsic heartbeat. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. Preferably, the method is used to detect tissue stiffness and to evaluate its stiffness due to intrinsic pulsatile motion from the heartbeat. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases and evaluating the efficacy of therapies.
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2.发明授权公开(公告)号：US12029492B2
公开(公告)日：2024-07-09
申请号：US18072838
申请日：2022-12-01
Applicant: University of Houston System
Inventor： Kirill V. Larin , Manmohan Singh , Jiasong Li , Zhaolong Han , Michael D. Twa
CPC classification number: A61B3/165 , A61B3/102 , A61B3/18 , A61B5/0066 , A61B5/7246 , A61B5/7289 , A61B3/107
Abstract: Provided herein are systems and methods to measure the intraocular pressure, ocular tissue geometry and the biomechanical properties of an ocular tissue, such as an eye-globe or cornea, in one instrument. The system is an optical coherence tomography subsystem and an applanation tonometer subsystem housed as one instrument and interfaced with a computer for at least data processing and image display. The system utilizes an air-puff and a focused micro air-pulse to induce deformation and applanation and displacement in the ocular tissue. Pressure profiles of the air puff with applanation times are utilized to measure intraocular pressure. Temporal profiles of displacement and/or spatio-temporal profiles of a displacement-generated elastic wave are analyzed to calculate biomechanical properties.
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公开(公告)号：US11839483B2
公开(公告)日：2023-12-12
申请号：US15748372
申请日：2016-08-25
Applicant: University of Houston System
Inventor： Kirill Larin , Richard Yee , Manmohan Singh
CPC classification number: A61B5/442 , A61B5/0066 , A61B5/4839 , A61B5/4848 , A61B2090/3735 , A61B2505/05
Abstract: Methods and systems for providing depth-resolved real-time visual feedback to a physician during cosmetic dermal filler injections with micrometer spatial resolution utilizing a noninvasive optical coherence tomography/elastography, 2D-3D virtual and real time system. This system can be automated to direct proper volumes and viscosity of the necessary injection substances. The methods and systems allow for assessment of the elasticity of the tissue before and after the injection to evaluate the efficacy of the injection, with predetermined virtual results before and matched post injection images. The elasticity assessment method preferably utilizes a focused air-pulse to induce a micrometer scale displacement in the skin and the optical coherence tomography system to image this displacement. By utilizing a model-based reconstruction method, the viscoelasticity of the tissue at a specific measurement position can be obtained and virtual and post injection real time projections can be imaged.
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公开(公告)号：US11406258B2
公开(公告)日：2022-08-09
申请号：US16907424
申请日：2020-06-22
Applicant: University of Houston System
Inventor： Kirill V. Larin , Achuth Nair , Manmohan Singh , Salavat Aglyamov
Abstract: A system and method for measuring biomechanical properties of tissues without external excitation are capable of measuring and quantifying these parameters of tissues in situ and in vivo. The system and method preferably utilize a phase-sensitive optical coherence tomography (OCT) system for measuring the displacement caused by the intrinsic heartbeat. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. Preferably, the method is used to detect tissue stiffness and to evaluate its stiffness due to intrinsic pulsatile motion from the heartbeat. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases and evaluating the efficacy of therapies.
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5.发明申请OPTICAL COHERENCE ELASTOGRAPHY TO ASSESS BIOMECHANICS AND DETECT PROGRESSION OF OCULAR AND OTHER TISSUES DEGENERATIVE DISEASES 有权评估生物力学的光学相干弹性学和检测其他组织变性疾病的进展公开(公告)号：US20160128558A1
公开(公告)日：2016-05-12
申请号：US14934663
申请日：2015-11-06
Applicant: University of Houston System
Inventor： Kirill V. Larin , Jiasong Li , Manmohan Singh , Chen Wu , Salavat Aglyamov
CPC classification number: A61B3/0025 , A61B3/102 , A61B3/16 , A61B3/165 , A61B5/0051 , A61B5/0053 , A61B5/0066 , A61B5/0093 , A61B5/0097 , A61B8/10 , A61B8/485 , A61B2576/00
Abstract: An excitation force (internal or external) and phase-sensitive optical coherence elastography (OCE) system, used in conjunction with a data analyzing algorithm, is capable of measuring and quantifying biomechanical parameters of tissues in situ and in vivo. The method was approbated and demonstrated on an example of the system that combines a pulsed ultrasound system capable of producing an acoustic radiation force on the crystalline lens surface and a phase-sensitive optical coherence tomography (OCT) system for measuring the lens displacement caused by the acoustic radiation force. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. The noninvasive measurement method also utilizes phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to distinguish between tissue stiffness, such as that attributable to disease, and effects on measured stiffness that result from external factors, such as pressure applied to the tissue. Preferably, the method is used to detect tissue stiffness and to evaluate the presence of its stiffness even if it is affected by other factors such as intraocular pressure (IOP) in the case of cornea, sclera, or the lens. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases (such as keratoconus).
Abstract translation: 与数据分析算法结合使用的激发力（内部或外部）和相敏光学相干弹性成像（OCE）系统能够测量和定量原位和体内组织的生物力学参数。 该方法被认为并证明了该系统的一个实例，其结合了能够在晶状体表面上产生声辐射力的脉冲超声系统和相敏光学相干断层扫描（OCT）系统，用于测量由 声辐射力。 该方法允许组织机械性质的无创和非破坏性定量。 非侵入性测量方法还利用相位稳定的扫频源光学相干弹性成像（PhS-SSOCE）来区分组织刚度，例如归因于疾病的组织刚度，以及由外部因素引起的测量刚度的影响，例如施加到组织上的压力 。 优选地，该方法用于检测组织刚度并评估其刚度的存在，即使其受角膜，巩膜或透镜的情况下的其他因素如眼内压（IOP）的影响。 这种非侵入性方法可以评估体内组织的生物力学性质，以检测退行性或其他疾病（如圆锥角膜）的发生和发展。
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Patent Agency Ranking
公开(公告)号：US11723529B2
公开(公告)日：2023-08-15
申请号：US17882682
申请日：2022-08-08
Applicant: University of Houston System
Inventor： Kirill V. Larin , Achuth Nair , Manmohan Singh , Salavat Aglyamov
CPC classification number: A61B3/0025 , A61B3/102 , A61B3/16 , A61B3/165 , A61B5/0051 , A61B5/0053 , A61B5/0066 , A61B5/0093 , A61B8/10 , A61B8/485 , A61B5/0097 , A61B2576/00
Abstract: A system and method for measuring biomechanical properties of tissues without external excitation are capable of measuring and quantifying these parameters of tissues in situ and in vivo. The system and method preferably utilize a phase-sensitive optical coherence tomography (OCT) system for measuring the displacement caused by the intrinsic heartbeat. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. Preferably, the method is used to detect tissue stiffness and to evaluate its stiffness due to intrinsic pulsatile motion from the heartbeat. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases and evaluating the efficacy of therapies.
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7.发明公开公开(公告)号：US20230210371A1
公开(公告)日：2023-07-06
申请号：US18072838
申请日：2022-12-01
Applicant: University of Houston System
Inventor： Kirill V. Larin , Manmohan Singh , Jiasong Li , Zhaolong Han , Michael D. Twa
CPC classification number: A61B3/18 , A61B3/165 , A61B3/102 , A61B5/7289 , A61B5/7246
Abstract: Provided herein are systems and methods to measure the intraocular pressure, ocular tissue geometry and the biomechanical properties of an ocular tissue, such as an eye-globe or cornea, in one instrument. The system is an optical coherence tomography subsystem and an applanation tonometer subsystem housed as one instrument and interfaced with a computer for at least data processing and image display. The system utilizes an air-puff and a focused micro air-pulse to induce deformation and applanation and displacement in the ocular tissue. Pressure profiles of the air puff with applanation times are utilized to measure intraocular pressure. Temporal profiles of displacement and/or spatio-temporal profiles of a displacement-generated elastic wave are analyzed to calculate biomechanical properties.
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8.发明申请公开(公告)号：US20180214069A1
公开(公告)日：2018-08-02
申请号：US15748372
申请日：2016-08-25
Applicant: University of Houston System
Inventor： Kirill Larin , Richard Yee , Manmohan Singh
IPC: A61B5/00
CPC classification number: A61B5/442 , A61B5/0066 , A61B5/4839 , A61B5/4848 , A61B2090/3735 , A61B2505/05
Abstract: Methods and systems for providing depth-resolved real-time visual feedback to a physician during cosmetic dermal filler injections with micrometer spatial resolution utilizing a noninvasive optical coherence tomography/elastography, 2D-3D virtual and real time system. This system can be automated to direct proper volumes and viscosity of the necessary injection substances. The methods and systems allow for assessment of the elasticity of the tissue before and after the injection to evaluate the efficacy of the injection, with predetermined virtual results before and matched post injection images. The elasticity assessment method preferably utilizes a focused air-pulse to induce a micrometer scale displacement in the skin and the optical coherence tomography system to image this displacement. By utilizing a model-based reconstruction method, the viscoelasticity of the tissue at a specific measurement position can be obtained and virtual and post injection real time projections can be imaged.
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9.发明申请公开(公告)号：US20170290503A1
公开(公告)日：2017-10-12
申请号：US15632657
申请日：2017-06-26
Applicant: University of Houston System
Inventor： Kirill V. Larin , Jiasong Li , Manmohan Singh , Chen Wu , Salavat Aglyamov
CPC classification number: A61B3/0025 , A61B3/102 , A61B3/16 , A61B3/165 , A61B5/0051 , A61B5/0053 , A61B5/0066 , A61B5/0093 , A61B5/0097 , A61B8/10 , A61B8/485 , A61B2576/00
Abstract: An excitation force (internal or external) and phase-sensitive optical coherence elastography (OCE) system, used in conjunction with a data analyzing algorithm, is capable of measuring and quantifying biomechanical parameters of tissues in situ and in vivo. The method was approbated and demonstrated on an example of the system that combines a pulsed ultrasound system capable of producing an acoustic radiation force on the crystalline lens surface and a phase-sensitive optical coherence tomography (OCT) system for measuring the lens displacement caused by the acoustic radiation force. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. The noninvasive measurement method also utilizes phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to distinguish between tissue stiffness, such as that attributable to disease, and effects on measured stiffness that result from external factors, such as pressure applied to the tissue. Preferably, the method is used to detect tissue stiffness and to evaluate the presence of its stiffness even if it is affected by other factors such as intraocular pressure (IOP) in the case of cornea, sclera, or the lens. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases (such as keratoconus).
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10.发明授权公开(公告)号：US11553839B2
公开(公告)日：2023-01-17
申请号：US16228979
申请日：2018-12-21
Applicant: University of Houston System
Inventor： Kirill V. Larin , Manmohan Singh , Jiasong Li , Zhaolong Han , Michael D. Twa
Abstract: Provided herein are systems and methods to measure the intraocular pressure, ocular tissue geometry and the biomechanical properties of an ocular tissue, such as an eye-globe or cornea, in one instrument. The system is an optical coherence tomography subsystem and an applanation tonometer subsystem housed as one instrument and interfaced with a computer for at least data processing and image display. The system utilizes an air-puff and a focused micro air-pulse to induce deformation and applanation and displacement in the ocular tissue. Pressure profiles of the air puff with applanation times are utilized to measure intraocular pressure. Temporal profiles of displacement and/or spatio-temporal profiles of a displacement-generated elastic wave are analyzed to calculate biomechanical properties.
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