公开(公告)号：US20240175870A1

公开(公告)日：2024-05-30

申请号：US18235751

申请日：2023-08-18

Applicant: University of Houston System

Inventor： Navin Varadarajan ,  Gabrielle Romain ,  Ivan Liadi ,  Victor G. Sendra ,  Badrinath Roysam

IPC: G01N33/569 ,  C12Q1/68 ,  C12Q1/6869 ,  G01N33/50

CPC classification number: G01N33/56966 ,  C12Q1/68 ,  C12Q1/6869 ,  G01N33/5005 ,  G01N2570/00

Abstract: Presented herein are methods of evaluating cellular activity by: placing a cell population on an area; assaying for a dynamic behavior of the cell population as a function of time; identifying cell(s) of interest based on the dynamic behavior; characterizing a molecular profile of the cell(s); and correlating the obtained information. The assayed dynamic behavior can include cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, and combinations thereof. Sensors associated with the area may be utilized to facilitate assaying. Molecular profiles of the cell(s) can then be characterized by various methods, such as DNA analysis, RNA analysis, and protein analysis. The dynamic behavior and molecular profile can then be correlated for various purposes, such as predicting clinical outcome of a treatment, screening cells, facilitating a treatment, diagnosing a disease, and monitoring cellular activity.

公开(公告)号：US20180217146A1

公开(公告)日：2018-08-02

申请号：US15560018

申请日：2016-03-28

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： Navin Varadarajan ,  Gabrielle Romain ,  Ivan Liadi ,  Victor Sendra ,  Badrinath Roysam

IPC: G01N33/569 ,  C12Q1/6869

CPC classification number: G01N33/56966 ,  C12Q1/68 ,  C12Q1/6869 ,  G01N33/5005 ,  G01N2570/00

Abstract: Presented herein are methods of evaluating cellular activity by: placing a cell population on an area; assaying for a dynamic behavior of the cell population as a function of time; identifying cell(s) of interest based on the dynamic behavior; characterizing a molecular profile of the cell(s); and correlating the obtained information. The assayed dynamic behavior can include cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, and combinations thereof. Sensors associated with the area may be utilized to facilitate assaying. Molecular profiles of the cell(s) can then be characterized by various methods, such as DNA analysis, RNA analysis, and protein analysis. The dynamic behavior and molecular profile can then be correlated for various purposes, such as predicting clinical outcome of a treatment, screening cells, facilitating a treatment, diagnosing a disease, and monitoring cellular activity.

公开(公告)号：US20210018503A1

公开(公告)日：2021-01-21

申请号：US16995559

申请日：2020-08-17

Applicant: University of Houston System

Inventor： Navin Varadarajan ,  Gabrielle Romain ,  Ivan Liadi ,  Victor Sendra ,  Badrinath Roysam

IPC: G01N33/569 ,  C12Q1/68 ,  G01N33/50 ,  C12Q1/6869

Abstract: Presented herein are methods of evaluating cellular activity by: placing a cell population on an area; assaying for a dynamic behavior of the cell population as a function of time; identifying cell(s) of interest based on the dynamic behavior; characterizing a molecular profile of the cell(s); and correlating the obtained information. The assayed dynamic behavior can include cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, and combinations thereof. Sensors associated with the area may be utilized to facilitate assaying. Molecular profiles of the cell(s) can then be characterized by various methods, such as DNA analysis, RNA analysis, and protein analysis. The dynamic behavior and molecular profile can then be correlated for various purposes, such as predicting clinical outcome of a treatment, screening cells, facilitating a treatment, diagnosing a disease, and monitoring cellular activity.

公开(公告)号：US11774449B2

公开(公告)日：2023-10-03

申请号：US16995559

申请日：2020-08-17

Applicant: University of Houston System

Inventor： Navin Varadarajan ,  Gabrielle Romain ,  Ivan Liadi ,  Victor Sendra ,  Badrinath Roysam

IPC: C12Q1/68 ,  G01N33/569 ,  G01N33/50 ,  C12Q1/6869

CPC classification number: G01N33/56966 ,  C12Q1/68 ,  C12Q1/6869 ,  G01N33/5005 ,  G01N2570/00

Abstract: Presented herein are methods of evaluating cellular activity by: placing a cell population on an area; assaying for a dynamic behavior of the cell population as a function of time; identifying cell(s) of interest based on the dynamic behavior; characterizing a molecular profile of the cell(s); and correlating the obtained information. The assayed dynamic behavior can include cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, and combinations thereof. Sensors associated with the area may be utilized to facilitate assaying. Molecular profiles of the cell(s) can then be characterized by various methods, such as DNA analysis, RNA analysis, and protein analysis. The dynamic behavior and molecular profile can then be correlated for various purposes, such as predicting clinical outcome of a treatment, screening cells, facilitating a treatment, diagnosing a disease, and monitoring cellular activity.

公开(公告)号：US10746736B2

公开(公告)日：2020-08-18

申请号：US15560018

申请日：2016-03-28

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： Navin Varadarajan ,  Gabrielle Romain ,  Ivan Liadi ,  Victor Sendra ,  Badrinath Roysam

IPC: G01N33/00 ,  G01N33/569 ,  C12Q1/68 ,  G01N33/50 ,  C12Q1/6869

Abstract: Presented herein are methods of evaluating cellular activity by: placing a cell population on an area; assaying for a dynamic behavior of the cell population as a function of time; identifying cell(s) of interest based on the dynamic behavior; characterizing a molecular profile of the cell(s); and correlating the obtained information. The assayed dynamic behavior can include cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, and combinations thereof. Sensors associated with the area may be utilized to facilitate assaying. Molecular profiles of the cell(s) can then be characterized by various methods, such as DNA analysis, RNA analysis, and protein analysis. The dynamic behavior and molecular profile can then be correlated for various purposes, such as predicting clinical outcome of a treatment, screening cells, facilitating a treatment, diagnosing a disease, and monitoring cellular activity.