公开(公告)号：US20230270845A1

公开(公告)日：2023-08-31

申请号：US18017659

申请日：2021-07-22

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： Navin Varadarajan ,  Xinli Liu

IPC: A61K39/215 ,  A61K39/39 ,  A61P31/14

CPC classification number: A61K39/215 ,  A61K39/39 ,  A61P31/14 ,  A61K2039/55555

Abstract: Described herein are compositions and methods for the prevention of pathogens such as conditions in an animal (e.g., a subject). In some cases, a composition or method described herein can comprise a liposome, which may be used to encapsulate one or more STING agonists. In some cases, a liposome of a composition or method described herein may comprise one or more antigens attached to, integrated into, or associated with a liposomal membrane of the liposome.

公开(公告)号：US20230338511A1

公开(公告)日：2023-10-26

申请号：US18023891

申请日：2021-08-27

Applicant: University of Houston System

Inventor： Ke-He Ruan ,  Xinli Liu ,  Renzhong Lu

IPC: A61K39/215 ,  C07K14/005 ,  A61K9/127 ,  A61P31/14 ,  C12N15/86

CPC classification number: A61K39/215 ,  C07K14/005 ,  A61K9/127 ,  A61P31/14 ,  C12N15/86 ,  A61K2039/53

Abstract: Recombinant protein coronavirus antigens and vaccine compositions using the same, include a recombinant protein that is a single-chain (SC) viral membrane protein complex derived from the spike (S), envelop (E) and membrane (M) protein of a coronaviruses such as SARS-CoV-2, the causal agent for COVID-19. Methods for immunization of a subject using the vaccine compositions treats or prevents clinical signs caused by coronaviruses infection.

公开(公告)号：US20230257420A1

公开(公告)日：2023-08-17

申请号：US18011649

申请日：2021-06-22

Applicant: University of Houston System

Inventor： Bin Guo ,  Damith Gomika Udugamasooriya ,  Xinli Liu ,  Satya Prakash Shukla ,  Kwang Bog Cho ,  Xue Zhou

IPC: C07K7/06 ,  A61K47/64 ,  A61P25/00

CPC classification number: C07K7/06 ,  A61K47/645 ,  A61P25/00

Abstract: Compounds disclosed herein have been shown to bind to the transferrin receptor making them capable of crossing the blood-brain barrier (BBB) and useful for treating diseases or disorders of the brain, such as cancer, ischemic stroke, Alzheimer's disease, or Parkinson's disease.