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公开(公告)号：WO2007127801A3
公开(公告)日：2008-09-12
申请号：PCT/US2007067421
申请日：2007-04-25
Applicant: VERTEX PHARMA , RAMACHANDRAN RAVI K , HARDING MATTHEW W , CARON PAUL R , BOTFIELD MARTYN C , HARE BRIAN J , BANDARU RAJ , KELLIHER KEVIN M , CORNELL CATHARINE N
Inventor： RAMACHANDRAN RAVI K , HARDING MATTHEW W , CARON PAUL R , BOTFIELD MARTYN C , HARE BRIAN J , BANDARU RAJ , KELLIHER KEVIN M , CORNELL CATHARINE N
CPC classification number: C12Q1/707 , C12Q2545/114
Abstract: A signature set of genes associated with hepatitis C virus infection is described. Figure 1 depicts a line graph demonstrating median HCV RNA levels (y axis) over time (x axis) in HCV infected patients after treatment with VX-950 or a placebo control.
Abstract translation: 描述了与丙型肝炎病毒感染相关的基因的一组签名。 图1描绘了在用VX-950或安慰剂对照治疗后HCV感染患者中随时间（x轴）显示中位HCV RNA水平（y轴）的线图。
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公开(公告)号：EP2016195A4
公开(公告)日：2010-03-10
申请号：EP07761284
申请日：2007-04-25
Applicant: VERTEX PHARMA
Inventor： RAMACHANDRAN RAVI K , HARDING MATTHEW W , CARON PAUL R , BOTFIELD MARTYN C , HARE BRIAN J , BANDARU RAJ , KELLIHER KEVIN M , CORNELL CATHARINE N
CPC classification number: C12Q1/707 , C12Q2545/114
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公开(公告)号：MX2008013796A
公开(公告)日：2009-03-31
申请号：MX2008013796
申请日：2007-04-25
Applicant: VERTEX PHARMA
Inventor： RAMACHANDRAN RAVI K , HARDING MATTHEW W , CARON PAUL R , BOTFIELD MARTYN C , HARE BRIAN J , BANDARU RAJ , KELLIHER KEVIN M , CORNELL CATHERINE N
Abstract: Se describe un conjunto de firma de genes asociados con la infección por el virus de hepatitis C. La Figura 1 ilustra una gráfica de líneas que demuestra los niveles medios de ARN de HCV (eje y) a través del tiempo (eje x) en los pacientes infectados por el virus de hepatitis C, después del tratamiento con VX-950 o con un control de placebo.
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Patent Agency Ranking
公开(公告)号：NZ573052A
公开(公告)日：2012-03-30
申请号：NZ57305207
申请日：2007-04-25
Applicant: VERTEX PHARMA
Inventor： RAMACHANDRAN RAVI K , HARDING MATTHEW W , CARON PAUL R , BOTFIELD MARTYN , HARE BRIAN J , BANDARU RAJ , KELLIHER KEVIN M , CORNELL CATHARINE N
Abstract: Disclosed is a method of evaluating a subject, the method comprising: determining the expression levels of the genes in a signature set of genes in the subject, wherein the signature set of genes comprises one or more interferon-sensitive genes(ISG) selected from the group consisting of IFIT1, RSAD2, IFIT2, IFIT6, IFI44, IFIT5, PLSCR1, IFIT3, IFI35, IFITM1, IFITM3, IFI30, IFITM2, GIP2, OAS3, MX1, IFIL44L, IFI27, IFIT2A, PRSAD, or IFITA, wherein the signature set has the following properties: it includes a plurality of genes each of which is differentially expressed as between virally infected individuals and non-infected individuals, and the differential expression is predictive of infection with no more than about 15% false positives; and comparing the expression level of each of the genes in the set from the subject with a reference value, thereby evaluating the subject, wherein the reference value is either: (i) a non-infected reference and wherein differential expression of each of the genes in the signature set of genes indicates a first state, and differential expression of less than all of the genes in the signature set indicates a second state; or (ii) an infected reference and wherein non-differential expression of each of the genes in the signature set of genes indicates a first state, and non-differential expression of less than all of the genes in the signature set indicates a second state, wherein the evaluating occurs prior to, during the course of, or after administering an inhibitor of a viral protease to the subject, and wherein the evaluation of the expression of the genes in a signature set of genes is performed on an isolated sample from the subject.
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公开(公告)号：NO20084954L
公开(公告)日：2009-01-22
申请号：NO20084954
申请日：2008-11-25
Applicant: VERTEX PHARMA
Inventor： BOTFIELD MARTYN C , RAMACHANDRAN RAVI K , HARDING MATTHEW W , CARON PAUL R , HARE BRIAN J , BANDARU RAJ , KELLIHER KEVIN M , CORNELL CATHARINE N
IPC: C12Q1/70
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公开(公告)号：NO20084954A
公开(公告)日：2009-01-22
申请号：NO20084954
申请日：2008-11-25
Applicant: VERTEX PHARMA
Inventor： BOTFIELD MARTYN C , RAMACHANDRAN RAVI K , HARDING MATTHEW W , CARON PAUL R , HARE BRIAN J , BANDARU RAJ , KELLIHER KEVIN M , CORNELL CATHARINE N
IPC: C12Q1/70
CPC classification number: C12Q1/707 , C12Q2545/114
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公开(公告)号：CA2650616A1
公开(公告)日：2007-11-08
申请号：CA2650616
申请日：2007-04-25
Applicant: VERTEX PHARMA
Inventor： CORNELL CATHARINE N , BOTFIELD MARTYN C , KELLIHER KEVIN M , BANDARU RAJ , HARE BRIAN J , RAMACHANDRAN RAVI K , CARON PAUL R , HARDING MATTHEW W
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公开(公告)号：AU2007244824A1
公开(公告)日：2007-11-08
申请号：AU2007244824
申请日：2007-04-25
Applicant: VERTEX PHARMA
Inventor： CARON PAUL R , BOTFIELD MARTYN C , HARE BRIAN J , KELLIHER KEVIN M , HARDING MATTHEW W , CORNELL CATHARINE N , RAMACHANDRAN RAVI K , BANDARU RAJ
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