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    Phenyl-sulfinyl-sulfamoylphenyl-benzamide derivatives that inhibit voltage-gated sodium channels
    2.
    发明专利
    Phenyl-sulfinyl-sulfamoylphenyl-benzamide derivatives that inhibit voltage-gated sodium channels 未知

    公开(公告)号：NZ596413A

    公开(公告)日：2013-03-28

    申请号：NZ59641307

    申请日：2007-04-11

    Applicant: VERTEX PHARMA

    Inventor： JOSHI PRAMOD ,  KRENITSKY PAUL ,  GONZALEZ JESUS ,  WANG JIAN ,  WILSON DEAN ,  TERMIN ANDREAS

    IPC: C07D295/20 ,  A61K31/18 ,  A61P29/00 ,  C07C311/46 ,  C07C323/62 ,  C07D207/32 ,  C07D213/65 ,  C07D213/74 ,  C07D233/54 ,  C07D239/34 ,  C07D317/60

    Abstract: ABSTRACT - 596413 The disclosure relates to phenylsulfinyl-3-sulfamoylphenyl-benzamide compounds of formula (I), which are useful as inhibitors of voltage-gated sodium channels, wherein the variables are as defined in the specification. The disclosure also provides pharmaceutically acceptable compositions comprising said compounds and their use for treating or lessening the severity in a subject of acute, chronic, neuropathic, or inflammatory pain, arthritis, migraine, cluster headaches, epilepsy, neurodegenerative disorders, psychiatric disorders, anxiety, depression, dipolar disorder, myotonia, arrhythmia, movement disorders, neuroendocrine disorders, ataxia, multiple sclerosis, irritable bowel syndrome, incontinence, visceral pain, osteoarthritis pain, back pain, head pain, neck pain, severe pain, intractable pain, nociceptive pain, breakthrough pain, postsurgical pain, cancer pain, stroke, cerebral ischemia, traumatic brain injury, amyotrophic lateral sclerosis, stress-induced angina, exercise induced angina, palpitations, hypertension, migraine, or abnormal gastro-intestinal motility.

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