-
公开(公告)号：WO2013130669A8
公开(公告)日：2014-03-27
申请号：PCT/US2013028097
申请日：2013-02-27
Applicant: VERTEX PHARMA
Inventor： DOKOU ELENI , JAMZAD SHAHLA , CAESAR JOHN P JR , FAWAZ MAJED , DAS LAURA , GU CHONG-HUI , HURTER PATRICIA NELL , ISRANI MEGHNA JAI , JOHNSTON MEGHAN M , KNEZIC DRAGUTIN , KUZMISSION ANDREW G , WANG HONGREN
CPC classification number: A61K9/205 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/4808 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K31/47 , A61K47/02 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/38 , C07D215/56
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N- [2,4-Bis( 1,1 -dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.
Abstract translation: 本发明涉及含有N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，其包括 粉末，颗粒和微型片剂的固体分散体，粉末的制造和加工方法，颗粒剂和迷你片剂，以及使用该药物组合物治疗囊性纤维化的方法。
-
公开(公告)号：WO2012027731A2
公开(公告)日：2012-03-01
申请号：PCT/US2011049467
申请日：2011-08-26
Applicant: VERTEX PHARMA , DOKOU ELENI , JAMZAD SHAHLA
Inventor： DOKOU ELENI , JAMZAD SHAHLA
IPC: A61K9/14
CPC classification number: A61K9/2072 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/4808 , A61K9/4858 , A61K31/47
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-B is( 1, 1 -dimethylethyl)-5-hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3- carboxamide including formulations of the solid dispersions into powders, granules and mini- tablets, methods for manufacturing and processing the powders and mini-tablets and methods for treating cystic fibrosis employing the pharmaceutical composition.
Abstract translation: 本发明涉及含有N- [2,4-B是（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，包括 粉末，颗粒和微粒的固体分散体，制造和加工粉末的方法和微型片剂以及使用药物组合物治疗囊性纤维化的方法。
-
公开(公告)号：MX389751B
公开(公告)日：2025-03-20
申请号：MX2018014873
申请日：2014-08-26
Applicant: VERTEX PHARMA
Inventor： KUZMISSION ANDREW G , GU CHONG-HUI , KNEZIC DRAGUTIN , DOKOU ELENI , WANG HONGREN , P CAESAR JR JOHN , DAS LAURA , FAWAZ MAJED , JOHNSTON MEGHAN M , ISRANI MEGHNA JAI , HURTER PATRICIA NELL , JAMZAD SHAHLA
Abstract: La presente invención se refiere a composiciones farmacéuticas que contienen una dispersión sólida de N-[2,4-Bis(1,1-dimetilletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida incluyendo formulaciones de dispersiones sólidas en polvos, gránulos y minicomprimidos, métodos para fabricar y procesar los polvos, gránulos y minicomprimidos, y métodos para tratar fibrosis quística empleando la composición farmacéutica.
-
公开(公告)号：HK1205690A1
公开(公告)日：2015-12-24
申请号：HK15106314
申请日：2015-07-02
Applicant: VERTEX PHARMA
Inventor： DOKOU ELENI , JAMZAD SHAHLA , CAESAR JOHN P JR , FAWAZ MAJED , DAS LAURA , GU CHONG-HUI , HURTER PATRICIA NELL , ISRANI MEGHNA JAI , JOHNSTON MEGHAN M , KNEZIC DRAGUTIN , KUZMISSION ANDREW G , WANG HONGREN
IPC: A61K20060101
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.
-
公开(公告)号：AU2013226076A2
公开(公告)日：2014-09-25
申请号：AU2013226076
申请日：2013-02-27
Applicant: VERTEX PHARMA
Inventor： DOKOU ELENI , JAMZAD SHAHLA , CAESAR JR JOHN P , FAWAZ MAJED , DAS LAURA , GU CHONG-HUI , HURTER PATRICIA NELL , ISRANI MEGHNA JAI , JOHNSTON MEGHAN M , KNEZIC DRAGUTIN , KUZMISSION ANDREW G , WANG HONGREN
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N- [2,4-B is( 1, 1 -dimethy lethyl)-5 -hydroxypheny 1] - 1,4-dihydro-4-oxoquinoline-3 - carboxamide including formulations of the solid dispersions into powders, granules and mini- tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.
-
Patent Agency Ranking
公开(公告)号：CA2809263A1
公开(公告)日：2012-03-01
申请号：CA2809263
申请日：2011-08-26
Applicant: VERTEX PHARMA
Inventor： DOKOU ELENI , JAMZAD SHAHLA
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-B is( 1, 1 -dimethylethyl)-5-hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3- carboxamide including formulations of the solid dispersions into powders, granules and mini- tablets, methods for manufacturing and processing the powders and mini-tablets and methods for treating cystic fibrosis employing the pharmaceutical composition.
-
公开(公告)号：NZ629199A
公开(公告)日：2017-01-27
申请号：NZ62919913
申请日：2013-02-27
Applicant: VERTEX PHARMA
Inventor： DOKOU ELENI , JAMZAD SHAHLA , CAESAR JOHN P JR , FAWAZ MAJED , DAS LAURA , GU CHONG-HUI , HURTER PATRICIA NELL , ISRANI MEGHNA JAI , JOHNSTON MEGHAN M , KNEZIC DRAGUTIN , KUZMISSION ANDREW G , WANG HONGREN
Abstract: The disclosure relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating CFTR mediated disease in a pediatric patient employing the pharmaceutical composition, wherein the CFTR mediated disease is cystic fibrosis, COPD, emphysema, dry-eye disease or osteoporosis. Particularly disclosed is a pharmaceutical composition comprising: about 35 wt% of a solid dispersion by weight of the composition, wherein the dispersion comprises about 80 wt% by weight of the dispersion of substantially amorphous or amorphous Compound 1, wherein less than about 15% of Compound 1 is in crystalline form, about 19.5 wt% of hydroxylpropylmethylcellulose acetate succinate (HPMCAS) by weight of the dispersion, and about 0.5 wt% sodium lauryl sulfate (SLS) by weight of the dispersion; about 13.5 wt% of mannitol by weight of the composition; about 41 wt% of lactose by weight of the composition; about 2 wt% of sucralose by weight of the composition; about 6 wt% of croscarmellose sodium by weight of the composition; about 1 wt% of colloidal silicon dioxide by weight of the composition; and about 1.5 wt% of magnesium stearate by weight of the composition.
-
公开(公告)号：MX2014010253A
公开(公告)日：2014-11-12
申请号：MX2014010253
申请日：2013-02-27
Applicant: VERTEX PHARMA
Inventor： JAMZAD SHAHLA , CAESAR JOHN P JR , FAWAZ MAJED , DAS LAURA , GU CHONG-HUI , HURTER PATRICIA NELL , JOHNSTON MEGHAN M , KUZMISSION ANDREW G , DOKOU ELENI , ISRANI MEGHNA JAI , KNEZIC DRAGUTIN , WANG HONGREN
Abstract: La presente invención se refiere a composiciones farmacéuticas que contienen una dispersión sólida de N-[2,4-Bis(1,1-dimetilletil )-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida incluyendo formulaciones de dispersiones sólidas en polvos, gránulos y minicomprimidos, métodos para fabricar y procesar los polvos, gránulos y minicomprimidos, y métodos para tratar fibrosis quística empleando la composición farmacéutica.
-
9.发明专利
公开(公告)号：MX2014005565A
公开(公告)日：2014-05-30
申请号：MX2014005565
申请日：2012-11-06
Applicant: VERTEX PHARMA
Inventor： KADIYALA IRINA NIKOLAEVNA , JAMZAD SHAHLA , HOOCK THOMAS CARL , TAYLOR LORI KELL , SEWELL KATHRYN LEA
IPC: A61K45/06 , A61K31/506 , A61P29/00
Abstract: La presente invención proporciona un método para tratar o disminuir la severidad de una enfermedad seleccionada de espondiloartropatía, lupus eritematoso sistémico, artritis reumatoide, o cualquier combinación de los mismos que comprende administración de un compuesto de la Fórmula I y una co-terapia opcional (por ejemplo, agente de quimioterapia, DMARD, o cualquier combinación de estos). La presente invención también proporciona una composición farmacéutica que comprende un compuesto de la Fórmula I, un método para elaborar una composición farmacéutica que comprende un compuesto de la Fórmula I, y un método para administrar una composición farmacéutica que comprende una forma sólida de un compuesto de la Fórmula I.
-
10.发明专利
公开(公告)号：AU2012336019A1
公开(公告)日：2014-05-29
申请号：AU2012336019
申请日：2012-11-06
Applicant: VERTEX PHARMA
Inventor： KADIYALA IRINA NIKOLAEVNA , JAMZAD SHAHLA , HOOCK THOMAS CARL , TAYLOR LORI KELL , SEWELL KATHRYN LEA
IPC: A61K31/506 , A61K45/06 , A61P29/00
Abstract: The present invention provides method of treating or lessening the severity of a disease selected from spondyloarthropathy, systemic lupus erythematosus, rheumatoid arthritis, or any combination thereof comprising the administration of a compound of Formula I and an optional co-therapy (e.g., chemotherapy agent, DMARD, or any combination thereof). The present invention also provides a pharmaceutical composition comprising a compound of Formula I, a method of manufacturing a pharmaceutical composition comprising a compound of Formula I, and a method of administering a pharmaceutical composition comprising a solid form of a compound of Formula I.
-
-
-
-
-
-
-
-
-
Search Results
19
records
(took 0.023 seconds)
