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公开(公告)号：WO2013130669A8
公开(公告)日：2014-03-27
申请号：PCT/US2013028097
申请日：2013-02-27
Applicant: VERTEX PHARMA
Inventor： DOKOU ELENI , JAMZAD SHAHLA , CAESAR JOHN P JR , FAWAZ MAJED , DAS LAURA , GU CHONG-HUI , HURTER PATRICIA NELL , ISRANI MEGHNA JAI , JOHNSTON MEGHAN M , KNEZIC DRAGUTIN , KUZMISSION ANDREW G , WANG HONGREN
CPC classification number: A61K9/205 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/4808 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K31/47 , A61K47/02 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/38 , C07D215/56
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N- [2,4-Bis( 1,1 -dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.
Abstract translation: 本发明涉及含有N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，其包括 粉末，颗粒和微型片剂的固体分散体，粉末的制造和加工方法，颗粒剂和迷你片剂，以及使用该药物组合物治疗囊性纤维化的方法。
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2.发明申请PROCESS OF PREPARING PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR MEDIATED DISEASES 审中-公开制备用于治疗CFTR介导的疾病的药物组合物的方法
公开(公告)号：WO2015073231A1
公开(公告)日：2015-05-21
申请号：PCT/US2014063506
申请日：2014-10-31
Applicant: VERTEX PHARMA , SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
IPC: A61K31/435 , A61K31/44 , A61K31/47 , A61P43/00
CPC classification number: A61K9/2095 , A61K9/146 , A61K9/1652 , A61K9/1682 , A61K9/1694 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K31/443 , A61K31/47 , A61K45/06 , A61K2300/00
Abstract: Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2- difluorobenzo[d][1,3] dioxol-5 -yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5- hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-lH-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.
Abstract translation: 制备包含3-（6-（1-（2,2-二氟苯并[d] [1,3]间二氧杂环戊烯-5-基）环丙烷甲酰氨基）-3-甲基吡啶-2-基）苯甲酸（化合物1 ）以及包含基本上无定形的N-（5-羟基-2,4-二叔丁基 - 苯基）-4-氧代-1H-喹啉-3-甲酰胺（化合物2）的固体分散体，治疗方法，减轻 披露了CFTR介导的疾病例如囊性纤维化的严重性或对症治疗，施用方法及其试剂盒。
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3.发明公开PROCESS OF PREPARING PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR MEDIATED DISEASES 审中-公开程序对药物组合物中疾病介导的CFTR制备治疗
公开(公告)号：EP3068392A4
公开(公告)日：2017-05-31
申请号：EP14862504
申请日：2014-10-31
Applicant: VERTEX PHARMA
Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
IPC: A61K31/443 , A61K9/16 , A61K9/20 , A61K31/47 , A61K45/06
CPC classification number: A61K9/2095 , A61K9/146 , A61K9/1652 , A61K9/1682 , A61K9/1694 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K31/443 , A61K31/47 , A61K45/06 , A61K2300/00
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公开(公告)号：MX389751B
公开(公告)日：2025-03-20
申请号：MX2018014873
申请日：2014-08-26
Applicant: VERTEX PHARMA
Inventor： KUZMISSION ANDREW G , GU CHONG-HUI , KNEZIC DRAGUTIN , DOKOU ELENI , WANG HONGREN , P CAESAR JR JOHN , DAS LAURA , FAWAZ MAJED , JOHNSTON MEGHAN M , ISRANI MEGHNA JAI , HURTER PATRICIA NELL , JAMZAD SHAHLA
Abstract: La presente invención se refiere a composiciones farmacéuticas que contienen una dispersión sólida de N-[2,4-Bis(1,1-dimetilletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida incluyendo formulaciones de dispersiones sólidas en polvos, gránulos y minicomprimidos, métodos para fabricar y procesar los polvos, gránulos y minicomprimidos, y métodos para tratar fibrosis quística empleando la composición farmacéutica.
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5.发明专利
公开(公告)号：HRP20210516T2
公开(公告)日：2021-10-01
申请号：HRP20210516
申请日：2021-03-30
Applicant: VERTEX PHARMA
Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
IPC: A61K31/443 , A61K9/16 , A61K9/20 , A61K31/47 , A61K45/06
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Patent Agency Ranking
公开(公告)号：DK3068392T5
公开(公告)日：2021-09-20
申请号：DK14862504
申请日：2014-10-31
Applicant: VERTEX PHARMA
Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
IPC: A61K31/443 , A61K9/16 , A61K9/20 , A61K31/47 , A61K45/06
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7.发明专利
公开(公告)号：SI3068392T1
公开(公告)日：2021-07-30
申请号：SI201431804
申请日：2014-10-31
Applicant: VERTEX PHARMA
Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
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公开(公告)号：NZ629199A
公开(公告)日：2017-01-27
申请号：NZ62919913
申请日：2013-02-27
Applicant: VERTEX PHARMA
Inventor： DOKOU ELENI , JAMZAD SHAHLA , CAESAR JOHN P JR , FAWAZ MAJED , DAS LAURA , GU CHONG-HUI , HURTER PATRICIA NELL , ISRANI MEGHNA JAI , JOHNSTON MEGHAN M , KNEZIC DRAGUTIN , KUZMISSION ANDREW G , WANG HONGREN
Abstract: The disclosure relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating CFTR mediated disease in a pediatric patient employing the pharmaceutical composition, wherein the CFTR mediated disease is cystic fibrosis, COPD, emphysema, dry-eye disease or osteoporosis. Particularly disclosed is a pharmaceutical composition comprising: about 35 wt% of a solid dispersion by weight of the composition, wherein the dispersion comprises about 80 wt% by weight of the dispersion of substantially amorphous or amorphous Compound 1, wherein less than about 15% of Compound 1 is in crystalline form, about 19.5 wt% of hydroxylpropylmethylcellulose acetate succinate (HPMCAS) by weight of the dispersion, and about 0.5 wt% sodium lauryl sulfate (SLS) by weight of the dispersion; about 13.5 wt% of mannitol by weight of the composition; about 41 wt% of lactose by weight of the composition; about 2 wt% of sucralose by weight of the composition; about 6 wt% of croscarmellose sodium by weight of the composition; about 1 wt% of colloidal silicon dioxide by weight of the composition; and about 1.5 wt% of magnesium stearate by weight of the composition.
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公开(公告)号：MX2014010253A
公开(公告)日：2014-11-12
申请号：MX2014010253
申请日：2013-02-27
Applicant: VERTEX PHARMA
Inventor： JAMZAD SHAHLA , CAESAR JOHN P JR , FAWAZ MAJED , DAS LAURA , GU CHONG-HUI , HURTER PATRICIA NELL , JOHNSTON MEGHAN M , KUZMISSION ANDREW G , DOKOU ELENI , ISRANI MEGHNA JAI , KNEZIC DRAGUTIN , WANG HONGREN
Abstract: La presente invención se refiere a composiciones farmacéuticas que contienen una dispersión sólida de N-[2,4-Bis(1,1-dimetilletil )-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida incluyendo formulaciones de dispersiones sólidas en polvos, gránulos y minicomprimidos, métodos para fabricar y procesar los polvos, gránulos y minicomprimidos, y métodos para tratar fibrosis quística empleando la composición farmacéutica.
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公开(公告)号：CA2865519C
公开(公告)日：2018-01-02
申请号：CA2865519
申请日：2013-02-27
Applicant: VERTEX PHARMA
Inventor： DOKOU ELENI , JAMZAD SHAHLA , CAESAR JOHN P JR , FAWAZ MAJED , DAS LAURA , GU CHONG-HUI , HURTER PATRICIA NELL , ISRANI MEGHNA JAI , JOHNSTON MEGHAN M , KNEZIC DRAGUTIN , KUZMISSION ANDREW G , WANG HONGREN
Abstract: The present invention relates to pharmaceutical compositions containing a solid dispersion of N- [2,4-B is( 1, 1 -dimethy lethyl)-5 -hydroxypheny 1] - 1,4-dihydro-4-oxoquinoline-3 - carboxamide including formulations of the solid dispersions into powders, granules and mini- tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.
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