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公开(公告)号：FI3470063T3
公开(公告)日：2025-03-05
申请号：FI18192504
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS , KARKARE RADHIKA , MOORE MICHAEL
IPC: A61P11/00 , A61K9/20 , A61K31/443 , A61K31/47 , A61K45/06
Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.
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公开(公告)号：HUE039864T2
公开(公告)日：2019-02-28
申请号：HUE13792149
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS , KARKARE RADHIKA , MOORE MICHAEL
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公开(公告)号：AU2018229528A1
公开(公告)日：2018-10-11
申请号：AU2018229528
申请日：2018-09-14
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS JACOBUS , KARKARE RADHIKA , MOORE MICHAEL DOUGLAS
IPC: A61K9/20 , A61K31/443 , A61K31/47 , A61K45/06
Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d] [1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-y) benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1 H-quinoline-3 carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.
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公开(公告)号：SG11201503365YA
公开(公告)日：2015-06-29
申请号：SG11201503365Y
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS JACOBUS , KARKARE RADHIKA , MOORE MICHAEL DOUGLAS
IPC: A61K9/20 , A61K31/443 , A61K31/47 , A61K45/06
Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.
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公开(公告)号：CA2890106A1
公开(公告)日：2014-05-08
申请号：CA2890106
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS JACOBUS , KARKARE RADHIKA , MOORE MICHAEL DOUGLAS
IPC: A61K9/20 , A61K31/443 , A61K31/47 , A61K45/06
Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5- yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4- oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.
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Patent Agency Ranking
公开(公告)号：SMT202500078T1
公开(公告)日：2025-03-12
申请号：SMT202500078
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS JACOBUS , KARKARE RADHIKA , MOORE MICHAEL DOUGLAS
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公开(公告)号：DK3470063T3
公开(公告)日：2025-01-20
申请号：DK18192504
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS JACOBUS , KARKARE RADHIKA , MOORE MICHAEL DOUGLAS
IPC: A61P11/00 , A61K9/20 , A61K31/443 , A61K31/47 , A61K45/06
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公开(公告)号：RS57831B1
公开(公告)日：2018-12-31
申请号：RSP20181318
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS JACOBUS , KARKARE RADHIKA , MOORE MICHAEL DOUGLAS
IPC: A61K9/20 , A61K31/443 , A61K31/47 , A61K45/06
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公开(公告)号：LT2914248T
公开(公告)日：2018-11-26
申请号：LT13792149
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS , KARKARE RADHIKA , MOORE MICHAEL
IPC: A61K9/20 , A61K31/443 , A61K31/47 , A61K45/06
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公开(公告)号：CA2890106C
公开(公告)日：2022-08-02
申请号：CA2890106
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS JACOBUS , KARKARE RADHIKA , MOORE MICHAEL DOUGLAS
IPC: A61K9/20 , A61K31/443 , A61K31/47 , A61K45/06
Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5- yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4- oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.
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