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公开(公告)号：FI2464337T4
公开(公告)日：2024-07-18
申请号：FI10708442
申请日：2010-02-18
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS , OVERHOFF KIRK , GROOTENHUIS PETER , BOTFIELD MARTYN , GROSSI ALFREDO , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
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公开(公告)号：HUE056525T2
公开(公告)日：2022-02-28
申请号：HUE16185289
申请日：2011-04-07
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS , ALARGOVA ROSSITZA , KAUSHIK RITU , KADIYALA IRINA , YOUNG CHRISTOPHER
IPC: A61K9/16 , A61K9/20 , A61K9/28 , C07D213/75 , C07D405/12 , C07D405/14
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公开(公告)号：LT2914248T
公开(公告)日：2018-11-26
申请号：LT13792149
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS , KARKARE RADHIKA , MOORE MICHAEL
IPC: A61K9/20 , A61K31/443 , A61K31/47 , A61K45/06
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公开(公告)号：ES3009747T3
公开(公告)日：2025-03-31
申请号：ES18192504
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS , KARKARE RADHIKA , MOORE MICHAEL
IPC: A61P11/00 , A61K9/20 , A61K31/443 , A61K31/47 , A61K45/06
Abstract: Se describen composiciones farmacéuticas que comprenden ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiridin-2-il)benzoico (Compuesto 1) en la Forma I y una dispersión sólida que comprende N-(5-hidroxi-2,4-diterc-butil-fenil)-4-oxo-1H-quinolin-3-carboxamida sustancialmente amorfa (Compuesto 2), métodos para tratar, disminuir la gravedad o tratar sintomáticamente enfermedades mediadas por CFTR, tales como fibrosis quística, métodos de fabricación, métodos de administración y kits de las mismas. (Traducción automática con Google Translate, sin valor legal)
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公开(公告)号：LT3150198T
公开(公告)日：2021-12-10
申请号：LT16185289
申请日：2011-04-07
Applicant: VERTEX PHARMA
Inventor： KAUSHIK RITU , VERWIJS MARINUS , ALARGOVA ROSSITZA , KADIYALA IRINA , YOUNG CHRISTOPHER
IPC: A61K9/16 , A61K9/20 , A61K9/28 , A61K31/443 , A61K31/47 , A61P1/10 , A61P1/16 , A61P1/18 , A61P3/06 , A61P3/10 , A61P5/14 , A61P5/18 , A61P7/00 , A61P7/04 , A61P7/12 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/02 , A61P13/12 , A61P15/00 , A61P15/10 , A61P19/00 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/02 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P35/00 , A61P37/02 , A61P43/00 , C07D213/75 , C07D405/12 , C07D405/14 , C07D451/02
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Patent Agency Ranking
公开(公告)号：NZ745659A
公开(公告)日：2020-04-24
申请号：NZ74565913
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS , KARKARE RADHIKA , MOORE MICHAEL
IPC: A61K9/20 , A61K31/443 , A61K31/47
Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5- yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4- oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.
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公开(公告)号：NZ708474A
公开(公告)日：2019-02-22
申请号：NZ70847413
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS , KARKARE RADHIKA , MOORE MICHAEL
IPC: A61K9/20 , A61K31/443 , A61K31/47
Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5- yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4- oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.
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公开(公告)号：ES2694290T3
公开(公告)日：2018-12-19
申请号：ES13792149
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS , KARKARE RADHIKA , MOORE MICHAEL
IPC: A61K9/20 , A61K31/443 , A61K31/47 , A61K45/06
Abstract: Una composición farmacéutica que comprende: 100 mg o 200 mg de ácido 3-(6-(1-(2,2-difluorobenzo[d] [1,3] dioxo1-5-il) ciclopropanocarboxamido)-3- metilpiridin-2-il)benzoico Forma I ( Compuesto 1) y una dispersión sólida que comprende una N-(5-hidroxi-2,4-diterc-butilfenil)-4-oxo-1H-quinolina-3- carboxamida sustancialmente amorfa (Compuesto 2) y un polímero, en la que el Compuesto 2 sustancialmente amorfo está presente en la composición farmacéutica en una cantidad de 125 mg, en la que la Forma I del Compuesto 1 se caracteriza por uno o más picos a 15,4, 16,3 y 14,5 grados en un patrón de difracción de rayos X en polvo, y en la que el Compuesto 2 sustancialmente amorfo tiene menos del 15 % de cristalinidad.
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公开(公告)号：LT3470063T
公开(公告)日：2025-02-10
申请号：LT18192504
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS , KARKARE RADHIKA , MOORE MICHAEL
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公开(公告)号：ES2718273T5
公开(公告)日：2025-02-06
申请号：ES10708442
申请日：2010-02-18
Applicant: VERTEX PHARMA
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