公开(公告)号：ZA200602755B

公开(公告)日：2007-06-27

申请号：ZA200602755

申请日：2004-09-07

Applicant: VERTEX PHARMA

Inventor： MILLER MARK T ,  HADIDA RUAH SARA S ,  SINGH ASHAVINI K ,  THOMAS CLEVELAND ,  MARKINGS LEWIS R ,  MATTHEW HAMILTON ,  GROOTENHUIS PETER D J

IPC: A61K20090101 ,  A61K31/426 ,  A61K31/427 ,  A61P20090101 ,  A61P43/00 ,  C07D20090101 ,  C07D263/48 ,  C07D277/46 ,  C07D277/82 ,  C07D417/02 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.