公开(公告)号：WO2005026137A3

公开(公告)日：2005-07-21

申请号：PCT/US2004029206

申请日：2004-09-07

Applicant: VERTEX PHARMA ,  MILLER MARK T ,  HADIDA RUAH SARA S ,  SINGH ASHAVINI K ,  CLEVELAND THOMAS ,  MAKINGS LEWIS R ,  HAMILTON MATTHEW ,  GROOTENHUIS PETER D J

Inventor： MILLER MARK T ,  HADIDA RUAH SARA S ,  SINGH ASHAVINI K ,  CLEVELAND THOMAS ,  MAKINGS LEWIS R ,  HAMILTON MATTHEW ,  GROOTENHUIS PETER D J

IPC: A61K31/426 ,  A61K31/427 ,  A61P43/00 ,  C07D263/48 ,  C07D277/46 ,  C07D277/82 ,  C07D417/02 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

CPC classification number: A61K31/426 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  C07D263/48 ,  C07D277/46 ,  C07D277/82 ,  C07D295/15 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  G01N33/5076

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including CF Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：NO20061543A

公开(公告)日：2006-06-06

申请号：NO20061543

申请日：2006-04-05

Applicant: VERTEX PHARMA

Inventor： MILLER MARK T ,  RUAH SARA S HADIDA ,  SINGH ASHAVINI K ,  CLEVELAND THOMAS ,  MAKINGS LEWIS R ,  HAMILTON MATTHEW ,  GROOTENHUIS PETER D J

IPC: C07D263/48 ,  A61K31/426 ,  A61K31/427 ,  A61P43/00 ,  C07D277/46 ,  C07D277/82 ,  C07D417/02 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

CPC classification number: A61K31/426 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  C07D263/48 ,  C07D277/46 ,  C07D277/82 ,  C07D295/15 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  G01N33/5076

公开(公告)号：ZA200602755B

公开(公告)日：2007-06-27

申请号：ZA200602755

申请日：2004-09-07

Applicant: VERTEX PHARMA

Inventor： MILLER MARK T ,  HADIDA RUAH SARA S ,  SINGH ASHAVINI K ,  THOMAS CLEVELAND ,  MARKINGS LEWIS R ,  MATTHEW HAMILTON ,  GROOTENHUIS PETER D J

IPC: A61K20090101 ,  A61K31/426 ,  A61K31/427 ,  A61P20090101 ,  A61P43/00 ,  C07D20090101 ,  C07D263/48 ,  C07D277/46 ,  C07D277/82 ,  C07D417/02 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：NO20061543L

公开(公告)日：2006-06-06

申请号：NO20061543

申请日：2006-04-05

Applicant: VERTEX PHARMA

Inventor： MILLER MARK T ,  RUAH SARA S HADIDA ,  SINGH ASHAVINI K ,  CLEVELAND THOMAS ,  MAKINGS LEWIS R ,  HAMILTON MATTHEW ,  GROOTENHUIS PETER D J

IPC: C07D263/48 ,  A61K31/426 ,  A61K31/427 ,  A61P43/00 ,  C07D277/46 ,  C07D277/82 ,  C07D417/02 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：CA2537841A1

公开(公告)日：2005-03-24

申请号：CA2537841

申请日：2004-09-07

Applicant: VERTEX PHARMA

Inventor： GROOTENHUIS PETER D J ,  MAKINGS LEWIS R ,  CLEVELAND THOMAS ,  HAMILTON MATTHEW ,  SINGH ASHAVINI K ,  HADIDA RUAH SARA S ,  MILLER MARK T

IPC: C07D277/82 ,  A61K31/426 ,  A61K31/427 ,  A61P43/00 ,  C07D263/48 ,  C07D277/46 ,  C07D417/02 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including CF Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：AU2004272599A1

公开(公告)日：2005-03-24

申请号：AU2004272599

申请日：2004-09-07

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  SINGH ASHAVINI K ,  MILLER MARK T

IPC: C07D277/82 ,  A61K31/426 ,  A61K31/427 ,  A61P43/00 ,  C07D263/48 ,  C07D277/46 ,  C07D417/02 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.