公开(公告)号：WO2014164533A8

公开(公告)日：2015-07-23

申请号：PCT/US2014022723

申请日：2014-03-10

Applicant: VERTEX PHARMA

Inventor： ROSE PETER JAMISON ,  JUNG YOUNG CHUN ,  BLIGH CAVAN MCKEON ,  IBRAHIM SHEREEN ,  ANZALONE LUIGI ,  MILLER DAVID B JR ,  VAN ALSTEN JOHN GREGG ,  CURRAN TIMOTHY THOMAS

IPC: C07F9/02 ,  C07F9/165

CPC classification number: C07H1/02 ,  C07F9/20 ,  C07F9/242 ,  C07F9/26 ,  C07F9/585 ,  C07F9/65586 ,  C07H19/10

Abstract: The present invention relates to the novel diastereoselective syntheses for generating phosphorothioate compounds. Examples include nucleoside phosphorothioate analogs that are useful in treating diseases and/or conditions such as viral infections.

Abstract translation: 本发明涉及用于产生硫代磷酸酯化合物的新的非对映选择性合成。 实例包括可用于治疗疾病和/或病症如病毒感染的核苷硫代磷酸酯类似物。

公开(公告)号：EP3294717A1

公开(公告)日：2018-03-21

申请号：EP16725308

申请日：2016-05-11

Applicant: VERTEX PHARMA

Inventor： FARMER LUC J ,  BOYD MICHAEL JOHN ,  MILLER DAVID B JR ,  CWYNAR VALERIE ANN

IPC: C07D239/42 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07D239/42

Abstract: in the presence of water, an organic solvent, a base, and a transition metal catalyst to generate a compound of Formula (I) or a pharmaceutically acceptable salt thereof.