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1.发明申请
公开(公告)号：WO2014164533A8
公开(公告)日：2015-07-23
申请号：PCT/US2014022723
申请日：2014-03-10
Applicant: VERTEX PHARMA
Inventor： ROSE PETER JAMISON , JUNG YOUNG CHUN , BLIGH CAVAN MCKEON , IBRAHIM SHEREEN , ANZALONE LUIGI , MILLER DAVID B JR , VAN ALSTEN JOHN GREGG , CURRAN TIMOTHY THOMAS
CPC classification number: C07H1/02 , C07F9/20 , C07F9/242 , C07F9/26 , C07F9/585 , C07F9/65586 , C07H19/10
Abstract: The present invention relates to the novel diastereoselective syntheses for generating phosphorothioate compounds. Examples include nucleoside phosphorothioate analogs that are useful in treating diseases and/or conditions such as viral infections.
Abstract translation: 本发明涉及用于产生硫代磷酸酯化合物的新的非对映选择性合成。 实例包括可用于治疗疾病和/或病症如病毒感染的核苷硫代磷酸酯类似物。
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公开(公告)号：WO2011133751A9
公开(公告)日：2012-02-16
申请号：PCT/US2011033396
申请日：2011-04-21
Applicant: VERTEX PHARMA , TANOURY GERALD J , HARRISON CRISTIAN , LITTLER BENJAMIN JOSEPH , ROSE PETER JAMISON , HUGHES ROBERT MICHAEL , JUNG YOUNG CHUN , SIESEL DAVID ANDREW , LEE ELAINE CHUNGMIN , BELMONT DANIEL T
Inventor： TANOURY GERALD J , HARRISON CRISTIAN , LITTLER BENJAMIN JOSEPH , ROSE PETER JAMISON , HUGHES ROBERT MICHAEL , JUNG YOUNG CHUN , SIESEL DAVID ANDREW , LEE ELAINE CHUNGMIN , BELMONT DANIEL T
IPC: C07D209/12 , C07D317/60 , C07D405/12
CPC classification number: C07D317/46 , C07C209/74 , C07C225/06 , C07D209/12 , C07D317/60 , C07D405/12
Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2- (1 -hydroxy-2-methylpropan-2-yl)- 1H-indol-5 -yl)cyclopropanecarboxamide (Compound 1 ), useful for treating CFTR mediated diseases such as cystic fibrosis.
Abstract translation: （R）-1-（2,2-二氟苯并[d] [1,3]间二氧杂环戊烯-5-基）-N-（1-（2,3-二羟基丙基） -6-氟-2-（1-羟基-2-甲基丙烷-2-基）-1H-吲哚-5-基）环丙烷甲酰胺（化合物1），用于治疗CFTR介导的疾病如囊性纤维化。
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公开(公告)号：WO2011133751A3
公开(公告)日：2012-01-12
申请号：PCT/US2011033396
申请日：2011-04-21
Applicant: VERTEX PHARMA , TANOURY GERALD J , HARRISON CRISTIAN , LITTLER BENJAMIN JOSEPH , ROSE PETER JAMISON , HUGHES ROBERT MICHAEL , JUNG YOUNG CHUN , SIESEL DAVID ANDREW , LEE ELAINE CHUNGMIN , BELMONT DANIEL T
Inventor： TANOURY GERALD J , HARRISON CRISTIAN , LITTLER BENJAMIN JOSEPH , ROSE PETER JAMISON , HUGHES ROBERT MICHAEL , JUNG YOUNG CHUN , SIESEL DAVID ANDREW , LEE ELAINE CHUNGMIN , BELMONT DANIEL T
IPC: C07D209/12 , C07D317/60 , C07D405/12
CPC classification number: C07D317/46 , C07C209/74 , C07C225/06 , C07D209/12 , C07D317/60 , C07D405/12
Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2- (1 -hydroxy-2-methylpropan-2-yl)- 1H-indol-5 -yl)cyclopropanecarboxamide (Compound 1 ), useful for treating CFTR mediated diseases such as cystic fibrosis.
Abstract translation: 本发明的特征在于制备化合物如（R）-1-（2,2-二氟苯并[d] [1,3]间二氧杂环戊烯-5-基）-N-（1-（2,3-二羟基丙基） -6-氟-2-（1-羟基-2-甲基丙-2-基）-1H-吲哚-5-基）环丙烷甲酰胺（化合物1），可用于治疗CFTR介导的疾病如囊性纤维化。
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公开(公告)号：AR117395A2
公开(公告)日：2021-08-04
申请号：ARP190100512
申请日：2019-02-28
Applicant: VERTEX PHARMA
Inventor： BELMONT DANIEL T , LEE ELAINE CHUNGMIN , SIESEL DAVID A , JUNG YOUNG CHUN , HUGHES ROBERT M , ROSE PETER JAMISON , LITTLER BENJAMIN J , HARRISON CRISTIAN , TANOURY GERALD J
IPC: C07D209/12 , C07D209/24
Abstract: Un compuesto de fórmula (1) o una sal del mismo, en donde, independientemente, cada vez que aparecen: R² es -RJ, -ORJ, -N(RJ)₂, -NO₂, halógeno, -CN, -haloalquilo C₁₋₄, -haloalcoxi C₁₋₄, -C(O)N(RJ)₂, -NRJC(O)RJ, -SORJ, -SO₂RJ, -SO₂N(RJ)₂, -NRJSO₂RJ, -CORJ, -CO₂RJ, -NRJSO₂N(RJ)₂, o -COCORJ; RJ es hidrógeno o alifático C₁₋₆; R³ es alifático C₁₋₆ opcionalmente sustituido con OH, OP, -O-alifático C₁₋₆, arilo, heteroarilo, -O-arilo, u -O-heteroarilo; P es un grupo protector; y o es un entero de 0 a 3.
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公开(公告)号：DK3068782T3
公开(公告)日：2018-08-13
申请号：DK14802788
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , NUGENT WILLIAM ALOYSIUS , DVORNIKOVS VADIMS , ROSE PETER JAMISON
IPC: C07D471/04 , C07C51/083
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Patent Agency Ranking
公开(公告)号：AU2011242712B2
公开(公告)日：2016-01-28
申请号：AU2011242712
申请日：2011-04-21
Applicant: VERTEX PHARMA
Inventor： LEE ELAINE CHUNGMIN , TANOURY GERALD J , HARRISON CRISTIAN , LITTLER BENJAMIN JOSEPH , ROSE PETER JAMISON , HUGHES ROBERT MICHAEL , JUNG YOUNG CHUN , SIESEL DAVID ANDREW , BELMONT DANIEL T
IPC: C07D209/12 , C07D317/60 , C07D405/12
Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2- (1 -hydroxy-2-methylpropan-2-yl)- 1H-indol-5 -yl)cyclopropanecarboxamide (Compound 1 ), useful for treating CFTR mediated diseases such as cystic fibrosis.
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公开(公告)号：NZ603721A
公开(公告)日：2014-11-28
申请号：NZ60372111
申请日：2011-04-21
Applicant: VERTEX PHARMA
Inventor： LITTLER BENJAMIN JOSEPH , JUNG YOUNG CHUN , LEE ELAINE CHUNGMIN , HUGHES ROBERT MICHAEL , ROSE PETER JAMISON , TANOURY GERALD J , BELMONT DANIEL T , HARRISON CRISTIAN , SIESEL DAVID ANDREW
IPC: C07D209/12 , C07D317/60 , C07D405/12
Abstract: Disclosed herein is a method for preparing cycloalkylcarboxamido-indole compounds which are useful for treating CFTR mediated diseases such as cystic fibrosis. In particular a method of preparing a compound of formula I comprising the steps of: Reacting a compound of formula IA in a first organic solvent with a compound of formula IB; to form a compound of formula IC in the presence of a palladium catalyst; and Removing the –CO2RJ group from compound IC in a second organic solvent to form the compound of formula I.
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公开(公告)号：DK3421468T3
公开(公告)日：2021-01-11
申请号：DK18164040
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , NUGENT WILLIAM ALOYSIUS , DVORNIKOVS VADIMS , ROSE PETER JAMISON
IPC: C07D471/04 , C07C51/083
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公开(公告)号：PL3068782T3
公开(公告)日：2018-12-31
申请号：PL14802788
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , NUGENT WILLIAM ALOYSIUS , DVORNIKOVS VADIMS , ROSE PETER JAMISON
IPC: C07D471/04 , C07C51/083
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公开(公告)号：RS57541B1
公开(公告)日：2018-10-31
申请号：RSP20180952
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , NUGENT WILLIAM ALOYSIUS , DVORNIKOVS VADIMS , ROSE PETER JAMISON
IPC: C07D471/04 , C07C51/083
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