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1.发明申请PROCESS OF PREPARING PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR MEDIATED DISEASES 审中-公开制备用于治疗CFTR介导的疾病的药物组合物的方法
公开(公告)号：WO2015073231A1
公开(公告)日：2015-05-21
申请号：PCT/US2014063506
申请日：2014-10-31
Applicant: VERTEX PHARMA , SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
IPC: A61K31/435 , A61K31/44 , A61K31/47 , A61P43/00
CPC classification number: A61K9/2095 , A61K9/146 , A61K9/1652 , A61K9/1682 , A61K9/1694 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K31/443 , A61K31/47 , A61K45/06 , A61K2300/00
Abstract: Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2- difluorobenzo[d][1,3] dioxol-5 -yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5- hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-lH-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.
Abstract translation: 制备包含3-（6-（1-（2,2-二氟苯并[d] [1,3]间二氧杂环戊烯-5-基）环丙烷甲酰氨基）-3-甲基吡啶-2-基）苯甲酸（化合物1 ）以及包含基本上无定形的N-（5-羟基-2,4-二叔丁基 - 苯基）-4-氧代-1H-喹啉-3-甲酰胺（化合物2）的固体分散体，治疗方法，减轻 披露了CFTR介导的疾病例如囊性纤维化的严重性或对症治疗，施用方法及其试剂盒。
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2.发明公开PROCESS OF PREPARING PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR MEDIATED DISEASES 审中-公开程序对药物组合物中疾病介导的CFTR制备治疗
公开(公告)号：EP3068392A4
公开(公告)日：2017-05-31
申请号：EP14862504
申请日：2014-10-31
Applicant: VERTEX PHARMA
Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
IPC: A61K31/443 , A61K9/16 , A61K9/20 , A61K31/47 , A61K45/06
CPC classification number: A61K9/2095 , A61K9/146 , A61K9/1652 , A61K9/1682 , A61K9/1694 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K31/443 , A61K31/47 , A61K45/06 , A61K2300/00
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3.发明专利
公开(公告)号：SI3068392T1
公开(公告)日：2021-07-30
申请号：SI201431804
申请日：2014-10-31
Applicant: VERTEX PHARMA
Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
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4.发明专利
公开(公告)号：AU2014349010A1
公开(公告)日：2016-06-30
申请号：AU2014349010
申请日：2014-10-31
Applicant: VERTEX PHARMA
Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
IPC: A61K31/435 , A61K31/44 , A61K31/47 , A61P43/00
Abstract: Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2- difluorobenzo[d][1,3] dioxol-5 -yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5- hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-lH-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.
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5.发明专利
公开(公告)号：HRP20210516T2
公开(公告)日：2021-10-01
申请号：HRP20210516
申请日：2021-03-30
Applicant: VERTEX PHARMA
Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
IPC: A61K31/443 , A61K9/16 , A61K9/20 , A61K31/47 , A61K45/06
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Patent Agency Ranking
公开(公告)号：DK3068392T5
公开(公告)日：2021-09-20
申请号：DK14862504
申请日：2014-10-31
Applicant: VERTEX PHARMA
Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
IPC: A61K31/443 , A61K9/16 , A61K9/20 , A61K31/47 , A61K45/06
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7.发明专利
公开(公告)号：CA2930199C
公开(公告)日：2022-10-25
申请号：CA2930199
申请日：2014-10-31
Applicant: VERTEX PHARMA
Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
IPC: A61K31/443 , A61J3/10 , A61K9/20 , A61P11/00
Abstract: Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2- difluorobenzo[d][1,3] dioxol-5 -yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5- hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-lH-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.
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8.发明专利
公开(公告)号：PL3068392T3
公开(公告)日：2021-07-19
申请号：PL14862504
申请日：2014-10-31
Applicant: VERTEX PHARMA
Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
IPC: A61K31/443 , A61K9/16 , A61K9/20 , A61K31/47 , A61K45/06
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9.发明专利
公开(公告)号：HRP20210516T1
公开(公告)日：2021-05-14
申请号：HRP20210516
申请日：2021-03-30
Applicant: VERTEX PHARMA
Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
IPC: A61K31/443 , A61K9/16 , A61K9/20 , A61K31/47 , A61K45/06
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公开(公告)号：MX2016006118A
公开(公告)日：2016-07-21
申请号：MX2016006118
申请日：2014-10-31
Applicant: VERTEX PHARMA
Inventor： SMITH DAVID , HURTER PATRICIA NELL , SWINNEY KELLY ANN , NADIG DAVID E , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL
IPC: A61K31/435 , A61K31/44 , A61K31/47 , A61P43/00
Abstract: Se describen procesos de preparación de composiciones farmacéuticas que comprenden ácido 3-(6-(1-(2,2-difluorobenzo [d] [1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benz oico (Compuesto 1) en Forma 1 y una dispersión sólida que comprende sustancialmente N-(5-hidroxi-2,4-diterc-butilfenil)-4-ox o-1H-quinolin-3-carboxamida amorfa (Compuesto 2), métodos de tratamiento, disminución de la severidad de, o tratamiento sintomático de enfermedades mediadas por CFTR como la fibrosis quística, un método de administración, y equipos de los mismos.
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