Patent search ap:("VERTEX PHARMA") AND inv:"SMITH DAVID" Page 1

1.

发明申请
PROCESS OF PREPARING PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR MEDIATED DISEASES 审中-公开
Title translation: 制备用于治疗CFTR介导的疾病的药物组合物的方法

公开(公告)号：WO2015073231A1

公开(公告)日：2015-05-21

申请号：PCT/US2014063506

申请日：2014-10-31

Applicant: VERTEX PHARMA , SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL

Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL

IPC: A61K31/435 , A61K31/44 , A61K31/47 , A61P43/00

CPC classification number: A61K9/2095 , A61K9/146 , A61K9/1652 , A61K9/1682 , A61K9/1694 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K31/443 , A61K31/47 , A61K45/06 , A61K2300/00

Abstract: Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2- difluorobenzo[d][1,3] dioxol-5 -yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5- hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-lH-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.

Abstract translation: 制备包含3-（6-（1-（2,2-二氟苯并[d] [1,3]间二氧杂环戊烯-5-基）环丙烷甲酰氨基）-3-甲基吡啶-2-基）苯甲酸（化合物1 ）以及包含基本上无定形的N-（5-羟基-2,4-二叔丁基 - 苯基）-4-氧代-1H-喹啉-3-甲酰胺（化合物2）的固体分散体，治疗方法，减轻披露了CFTR介导的疾病例如囊性纤维化的严重性或对症治疗，施用方法及其试剂盒。

2.

发明公开
PROCESS OF PREPARING PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR MEDIATED DISEASES 审中-公开
Title translation: 程序对药物组合物中疾病介导的CFTR制备治疗

公开(公告)号：EP3068392A4

公开(公告)日：2017-05-31

申请号：EP14862504

申请日：2014-10-31

Applicant: VERTEX PHARMA

Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL

IPC: A61K31/443 , A61K9/16 , A61K9/20 , A61K31/47 , A61K45/06

CPC classification number: A61K9/2095 , A61K9/146 , A61K9/1652 , A61K9/1682 , A61K9/1694 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K31/443 , A61K31/47 , A61K45/06 , A61K2300/00

3.

发明专利
PROCÉDÉS DE PRÉPARATION DE COMPOSÉS DE PYRROLIDINE 未知

公开(公告)号：MA49752A

公开(公告)日：2021-04-21

申请号：MA49752

申请日：2018-08-02

Applicant: VERTEX PHARMA

Inventor： ANGELL PAUL T , HUGHES ROBERT M , LEWANDOWSKI BERENICE , LITTLER BENJAMIN J , NUGENT WILLIAM A , SMITH DAVID , STUDLEY JOHN

IPC: C07D207/06 , C07D207/263

4.

发明专利
PROCESSES FOR PREPARING PYRROLIDINE COMPOUNDS 未知

公开(公告)号：CA3071278A1

公开(公告)日：2019-02-07

申请号：CA3071278

申请日：2018-08-02

Applicant: VERTEX PHARMA

Inventor： ANGELL PAUL T , LEWANDOWSKI BERENICE , LITTLER BENJAMIN J , NUGENT WILLIAM A , SMITH DAVID , STUDLEY JOHN

IPC: C07D207/06 , C07D207/263

Abstract: Processes for preparing 5,5-dimethyl-3-methylenepyrrolidin-2-one, (S)-3,5,5-trimethylpyrrolidine-2-one, (R)-3,5,5-trimethylpyrrolidine-2-one, (S)-2,4,4-trimethylpyrrolidine, and (R)-2,4,4-trimethylpyrrolidine, and their salt forms are disclosed.

5.

发明专利
PROCESS OF PREPARING PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR MEDIATED DISEASES 未知

公开(公告)号：SG10201803930QA

公开(公告)日：2018-07-30

申请号：SG10201803930Q

申请日：2014-10-31

Applicant: VERTEX PHARMA

Inventor： SWINNEY KELLY , HURTER PATRICIA , NADIG DAVID , SMITH DAVID , THOMAS VANCE , WARMAN MARTIN

Abstract: PROCESS OF PREPARING PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR MEDIATED DISEASES Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2- difluorobenzo[d][1,3] dioxol-5 -yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5- hydroxy-2,4-ditert-butyl-phenyl)-4- oxo-lH-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed. Figure: None

6.

发明专利
Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases 未知

公开(公告)号：AU2014349010A1

公开(公告)日：2016-06-30

申请号：AU2014349010

申请日：2014-10-31

Applicant: VERTEX PHARMA

Inventor： SWINNEY KELLY ANN , HURTER PATRICIA NELL , NADIG DAVID E , SMITH DAVID , THOMAS VANCE HAYDEN , WARMAN MARTIN PAUL

IPC: A61K31/435 , A61K31/44 , A61K31/47 , A61P43/00

Abstract: Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2- difluorobenzo[d][1,3] dioxol-5 -yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5- hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-lH-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.

7.

发明专利
Process of preparing pharmaceutical compositions for the treatment of cftr mediated diseases 未知

公开(公告)号：NZ720958A

公开(公告)日：2022-02-25

申请号：NZ72095814

申请日：2014-10-31

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , SWINNEY KELLY , NADIG DAVID , SMITH DAVID , THOMAS VANCE , WARMAN MARTIN

IPC: A61K31/435 , A61K31/44 , A61K31/47 , A61P43/00

Abstract: Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2- difluorobenzo[d][1,3] dioxol-5 -yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5- hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-lH-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.