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公开(公告)号：WO2007117715A3
公开(公告)日：2008-01-10
申请号：PCT/US2007008975
申请日：2007-04-09
Applicant: VERTEX PHARMA , RUAH SARA S HADIDA , GROOTENHUIS PETER D J , VAN GOOR FREDERICK , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL
Inventor： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , VAN GOOR FREDERICK , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL
IPC: C07D405/12 , A61K31/404 , A61P31/00 , C07D405/14
CPC classification number: C07D405/12 , C07B59/002 , C07B2200/05 , C07D403/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/6872 , G01N2333/705 , G01N2500/02 , G01N2500/10
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Abstract translation: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：DK3091011T3
公开(公告)日：2018-02-26
申请号：DK16155334
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL , YANG XIAOQING
IPC: C07D405/12 , A61K31/404 , A61P31/00 , C07D403/12 , C07D405/14 , C07D471/04 , C07D487/04
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公开(公告)号：HUE026145T2
公开(公告)日：2016-05-30
申请号：HUE07755298
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL , YANG XIAOQING
IPC: A61P31/00
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公开(公告)号：DK2674428T3
公开(公告)日：2016-04-18
申请号：DK13167785
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL , YANG XIAOQING
IPC: C07D405/12 , A61K31/404 , A61P31/00 , C07D405/14 , C07D471/04
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公开(公告)号：DK2007756T3
公开(公告)日：2015-10-05
申请号：DK07755298
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL , VAN GOOR FREDRICK , YANG XIAOQING
IPC: C07D405/12 , A61K31/404 , A61P31/00 , C07D405/14
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Patent Agency Ranking
公开(公告)号：CA2869945A1
公开(公告)日：2007-10-18
申请号：CA2869945
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL , YANG XIAOQING
IPC: C07D405/12 , A61K31/404 , A61K31/41 , A61K31/4439 , A61K31/454 , C07D209/08 , C07D403/12 , C07D413/12 , G01N33/48
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：AU2007235260A1
公开(公告)日：2007-10-18
申请号：AU2007235260
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , MCCARTNEY JASON , ZHOU JINGLAN , GOOR FREDERICK VAN , MILLER MARK T , NUMA MEHDI MICHEL JAMEL , BEAR BRIAN , GROOTENHUIS PETER D J
IPC: C07D405/12 , A61K31/404 , A61P31/00 , C07D405/14
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：PL3327016T3
公开(公告)日：2021-10-04
申请号：PL17209175
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL , YANG XIAOQING
IPC: C07D405/12 , C07D405/14 , C07D471/04
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公开(公告)号：ES2659364T3
公开(公告)日：2018-03-15
申请号：ES16155334
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL , YANG XIAOQING
IPC: C07D405/12 , A61K31/404 , A61P31/00 , C07D403/12 , C07D405/14 , C07D471/04 , C07D487/04
Abstract: Un compuesto de fórmula IId:**Fórmula** o una sal farmacéuticamente aceptable del mismo; en donde ambos grupos R2, junto con los átomos a los que están unidos, forman un grupo seleccionado de:**Fórmula** en donde R'3 se selecciona independientemente de uno de los siguientes: -H, -CH3, -CH2CH3, -C(O)CH3, -CH2CH2OH, -C(O)OCH3,**Fórmula** y en donde cada R3 se selecciona independientemente de -H, -CH3, -CH2OH, -CH2CH3,-CH2CH2OH, -CH2CH2CH3, - NH2, halo, -OCH3, -CN, -CF3, -C(O)OCH2CH3,-S(O)2CH3, -CH2NH2, -C(O)NH2,**Fórmula**
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公开(公告)号：CA2869945C
公开(公告)日：2018-01-23
申请号：CA2869945
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL , YANG XIAOQING
IPC: C07D405/12 , A61K31/404 , A61K31/41 , A61K31/4439 , A61K31/454 , C07D209/08 , C07D403/12 , C07D413/12 , G01N33/48
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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