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公开(公告)号：SMT201300098B
公开(公告)日：2013-11-08
申请号：SM201300098
申请日：2013-09-06
Applicant: VERTEX PHARMA
Inventor： ZHANG BEILI , KRAWIEC MARIUSZ , BOTFIELD MARTYN , GROOTENHUIS PETER D J , GOOR FREDERICK VAN
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公开(公告)号：NO20081280L
公开(公告)日：2008-05-09
申请号：NO20081280
申请日：2008-03-11
Applicant: VERTEX PHARMA
Inventor： RUAH SARA HADIDA , ZHOU JINGLAN , GOOR FREDERICK VAN , MILLER MARK T , MC CARTNEY JASON , ARUMUGAM VIJAYALAKSMI
IPC: C07D417/14
Abstract: The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.
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公开(公告)号：AU2007235260A1
公开(公告)日：2007-10-18
申请号：AU2007235260
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , MCCARTNEY JASON , ZHOU JINGLAN , GOOR FREDERICK VAN , MILLER MARK T , NUMA MEHDI MICHEL JAMEL , BEAR BRIAN , GROOTENHUIS PETER D J
IPC: C07D405/12 , A61K31/404 , A61P31/00 , C07D405/14
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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Patent Agency Ranking
公开(公告)号：BRPI0919930A2
公开(公告)日：2016-02-16
申请号：BRPI0919930
申请日：2009-10-23
Applicant: VERTEX PHARMA
Inventor： HURLEY DENNIS , GOOR FREDERICK VAN , BINCH HAYLEY , FANNING LEV T D , BOTFIELD MARTYN , NUMA MEHDI MICHEL DJAMEL , GROOTENHUIS PETER D J , SHETH URVI , YANG XIAOQING
IPC: C07D451/02 , A61K31/439 , A61P11/00
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公开(公告)号：IN2423KON2014A
公开(公告)日：2015-05-01
申请号：IN2423KON2014
申请日：2014-10-30
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , GOOR FREDERICK VAN , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL
IPC: C07D405/12
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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6.发明专利
公开(公告)号：MX2008012945A
公开(公告)日：2009-01-15
申请号：MX2008012945
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： BEAR BRIAN , GROOTENHUIS PETER D J , RUAH SARA S HADIDA , GOOR FREDERICK VAN , ZHOU JINGLAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL
IPC: C07D405/12 , A61K31/404 , A61P31/00 , C07D405/14
Abstract: Los compuestos de la presente invención y sales farmacéuticamente aceptables de los mismos, son útiles como moduladores de los transportadores del Cartucho de Unión de ATP ("ABC") o fragmentos de los mismos, incluyendo Regulador de Conductancia de Transmembrana de Fibrosis Quística ("CFTR"). La presente invención también se refiere a métodos para tratar enfermedades mediadas por transportador de ABC usando los compuestos de la presente invención.
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公开(公告)号：NO20081280A
公开(公告)日：2008-05-09
申请号：NO20081280
申请日：2008-03-11
Applicant: VERTEX PHARMA
Inventor： RUAH SARA HADIDA , ZHOU JINGLAN , GOOR FREDERICK VAN , MILLER MARK T , MC CARTNEY JASON , ARUMUGAM VIJAYALAKSMI
IPC: C07D417/14
CPC classification number: C07D417/14 , A61K31/427
Abstract: The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.
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公开(公告)号：AU2006279810A1
公开(公告)日：2007-02-22
申请号：AU2006279810
申请日：2006-08-11
Applicant: VERTEX PHARMA
Inventor： ARUMUGAM VIJAYALAKSMI , ZHOU JINGLAN , MCCARTNEY JASON , MILLER MARK T , RUAH SARA HADIDA , GOOR FREDERICK VAN
IPC: C07D417/14 , A61K31/427 , A61P25/16
Abstract: The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.
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