公开(公告)号：AU2003245442B2

公开(公告)日：2009-02-05

申请号：AU2003245442

申请日：2003-06-11

Applicant: VERTEX PHARMA

Inventor： DRUMM JOSEPH ,  STAMOS DEAN ,  LIAO YUSHENG ,  DEININGER DAVID D ,  GRILLOT ANNE-LAURE ,  OLIVER-SHAFFER PATRICIA ,  CHARIFSON PAUL

IPC: A61K31/4439 ,  A61K31/444 ,  A61K31/50 ,  A61K31/506 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P11/00 ,  A61P13/02 ,  A61P13/08 ,  A61P17/00 ,  A61P27/16 ,  A61P31/04 ,  A61P43/00 ,  C07C275/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to a method for preparing these compounds.

公开(公告)号：DE60309701T2

公开(公告)日：2007-09-06

申请号：DE60309701

申请日：2003-06-11

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  DEININGER D ,  DRUMM JOSEPH ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  OLIVER-SHAFFER PATRICIA ,  STAMOS DEAN

IPC: A61K31/4439 ,  A61K31/444 ,  A61K31/50 ,  A61K31/506 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P11/00 ,  A61P13/02 ,  A61P13/08 ,  A61P17/00 ,  A61P27/16 ,  A61P31/04 ,  A61P43/00 ,  C07C275/06 ,  C07C275/64 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to a method for preparing these compounds.

公开(公告)号：ES2277088T3

公开(公告)日：2007-07-01

申请号：ES03739082

申请日：2003-06-11

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  DEININGER DAVID D ,  DRUMM JOSEPH ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  OLIVER-SHAFFER PATRICIA

IPC: A61K31/4439 ,  A61K31/444 ,  A61K31/50 ,  A61K31/506 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P11/00 ,  A61P13/02 ,  A61P13/08 ,  A61P17/00 ,  A61P27/16 ,  A61P31/04 ,  A61P43/00 ,  C07C275/06 ,  C07C275/64 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04

Abstract: Un compuesto de la **fórmula** o una sal farmacéuticamente aceptable del mismo, en el que: Q es -NH-; W es C-R4; X es CH; R1 es un anillo arilo de 5-6 miembros que tiene 1-3 heteroátomos que se seleccionan independientemente de oxígeno, nitrógeno o azufre, en el que: R1 está sustituido con 0-3 grupos que se seleccionan independientemente de R, oxo, CO2R'', OR'', N(R'')2, SR'', NO2, halógeno, CN, C(O)N(R'')2, NR''C(O)R'', SO2R'', SO2N(R'')2, o NR''SO2R''.

公开(公告)号：NO20054201L

公开(公告)日：2005-10-06

申请号：NO20054201

申请日：2005-09-09

Applicant: VERTEX PHARMA

Inventor： OLIVER-SHAFFER PATRICIA ,  SNOONIAN JOHN R

IPC: C07D213/56 ,  C07D213/75 ,  C07D213/79 ,  C07D213/80 ,  C07D213/803 ,  C07D213/82

Abstract: A compound of formula (A) or formula (B): wherein: each of X 1 , X 2 , X 3 , and X 4 is independently selected from fluoro or chloro; and R is H or methyl.

公开(公告)号：NO20050099L

公开(公告)日：2005-03-14

申请号：NO20050099

申请日：2005-01-07

Applicant: VERTEX PHARMA

Inventor： DEININGER DAVID D ,  GRILLOT ANNE-LAURE ,  CHARIFSON PAUL S ,  STAMOS DEAN ,  LIAO YUSHENG ,  DRUMM JOSEPH ,  OLIVER-SHAFFER PATRICIA

IPC: C07D401/04 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/50 ,  A61K31/506 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P11/00 ,  A61P13/02 ,  A61P13/08 ,  A61P17/00 ,  A61P27/16 ,  A61P31/04 ,  A61P43/00 ,  C07C275/06 ,  C07D401/14 ,  C07D403/04 ,  C07C275/64 ,  A61K31/4427

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to a method for preparing these compounds.

公开(公告)号：CA2489128A1

公开(公告)日：2003-12-24

申请号：CA2489128

申请日：2003-06-11

Applicant: VERTEX PHARMA

Inventor： OLIVER-SHAFFER PATRICIA ,  STAMOS DEAN ,  GRILLOT ANNE-LAURE ,  DEININGER DAVID D ,  CHARIFSON PAUL ,  LIAO YUSHENG ,  DRUMM JOSEPH

IPC: A61K31/4439 ,  A61K31/444 ,  A61K31/50 ,  A61K31/506 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P11/00 ,  A61P13/02 ,  A61P13/08 ,  A61P17/00 ,  A61P27/16 ,  A61P31/04 ,  A61P43/00 ,  C07C275/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  A61K31/4545

Abstract: The present invention relates to compounds of formula I, wherein X, Q, W, R1 , R2 and R3 are as defined in the claims, which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in, mammals. The present invention also relates to a method for preparing these compounds.

公开(公告)号：AT345132T

公开(公告)日：2006-12-15

申请号：AT03739082

申请日：2003-06-11

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  DEININGER DAVID D ,  DRUMM JOSEPH ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  OLIVER-SHAFFER PATRICIA ,  STAMOS DEAN

IPC: A61K31/4439 ,  A61K31/444 ,  A61K31/50 ,  A61K31/506 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P11/00 ,  A61P13/02 ,  A61P13/08 ,  A61P17/00 ,  A61P27/16 ,  A61P31/04 ,  A61P43/00 ,  C07C275/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07C275/64

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to a method for preparing these compounds.

公开(公告)号：PL374191A1

公开(公告)日：2005-10-03

申请号：PL37419103

申请日：2003-06-11

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  DEININGER DAVID D ,  DRUMM JOSEPH ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  OLIVER-SHAFFER PATRICIA ,  STAMOS DEAN

IPC: A61K31/4439 ,  A61K31/444 ,  A61K31/50 ,  A61K31/506 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P11/00 ,  A61P13/02 ,  A61P13/08 ,  A61P17/00 ,  A61P27/16 ,  A61P31/04 ,  A61P43/00 ,  C07C275/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to a method for preparing these compounds.

公开(公告)号：NO20054201D0

公开(公告)日：2005-09-09

申请号：NO20054201

申请日：2005-09-09

Applicant: VERTEX PHARMA

Inventor： OLIVER-SHAFFER PATRICIA ,  SNOONIAN JOHN R

IPC: C07D213/56 ,  C07D213/75 ,  C07D213/79 ,  C07D213/80 ,  C07D213/803 ,  C07D213/82 ,  C07D

Abstract: A compound of formula (A) or formula (B): wherein: each of X 1 , X 2 , X 3 , and X 4 is independently selected from fluoro or chloro; and R is H or methyl.

公开(公告)号：CA2489128C

公开(公告)日：2012-01-03

申请号：CA2489128

申请日：2003-06-11

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  DEININGER DAVID D ,  DRUMM JOSEPH ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  OLIVER-SHAFFER PATRICIA ,  STAMOS DEAN

IPC: C07D403/04 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/50 ,  A61K31/506 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P11/00 ,  A61P13/02 ,  A61P13/08 ,  A61P17/00 ,  A61P27/16 ,  A61P31/04 ,  A61P43/00 ,  C07C275/06 ,  C07D401/04 ,  C07D401/14

Abstract: The present invention relates to compounds of formula I, wherein X, Q, W, R1, R2 and R3 are as defined in the claims, which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in, mammals. The present invention also relates to a method for preparing these compounds.