公开(公告)号：CA2489128C

公开(公告)日：2012-01-03

申请号：CA2489128

申请日：2003-06-11

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  DEININGER DAVID D ,  DRUMM JOSEPH ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  OLIVER-SHAFFER PATRICIA ,  STAMOS DEAN

IPC: C07D403/04 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/50 ,  A61K31/506 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P11/00 ,  A61P13/02 ,  A61P13/08 ,  A61P17/00 ,  A61P27/16 ,  A61P31/04 ,  A61P43/00 ,  C07C275/06 ,  C07D401/04 ,  C07D401/14

Abstract: The present invention relates to compounds of formula I, wherein X, Q, W, R1, R2 and R3 are as defined in the claims, which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in, mammals. The present invention also relates to a method for preparing these compounds.

公开(公告)号：DK1592686T3

公开(公告)日：2009-10-19

申请号：DK04775744

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  DEININGER DAVID D ,  LIAO YUSHENG ,  RONKIN STEVEN M ,  STAMOS DEAN ,  PEROLA EMAUELE ,  WANG TIANSHENG ,  DRUMM JOSEPH ,  GRILLOT ANNE-LAURE ,  LE TIRAN ARNAUD

IPC: C07D403/14 ,  A61K31/4184 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

公开(公告)号：DE602004021644D1

公开(公告)日：2009-07-30

申请号：DE602004021644

申请日：2004-10-21

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  DEININGER DAVID D ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  RONKIN STEVEN M ,  STAMOS DEAN ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  LE TIRAN ARNAUD ,  DRUMM JOSEPH

IPC: C07D491/04 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/506 ,  A61P31/00 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

公开(公告)号：AU2004322641A1

公开(公告)日：2006-03-02

申请号：AU2004322641

申请日：2004-10-21

Applicant: VERTEX PHARMA

Inventor： PEROLA EMANUELE ,  DEININGER DAVID D ,  TIRAN ARNAUD LE ,  GRILLOT ANNE-LAURE ,  RONKIN STEVEN M ,  WANG TIANSHENG ,  STAMOS DEAN ,  CHARIFSON PAUL S ,  LIAO YUSHENG ,  DRUMM JOSEPH

IPC: C07D491/04 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/506 ,  A61P31/00 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

公开(公告)号：NO20050099A

公开(公告)日：2005-03-14

申请号：NO20050099

申请日：2005-01-07

Applicant: VERTEX PHARMA

Inventor： DEININGER DAVID D ,  GRILLOT ANNE-LAURE ,  CHARIFSON PAUL S ,  STAMOS DEAN ,  LIAO YUSHENG ,  DRUMM JOSEPH ,  OLIVER-SHAFFER PATRICIA

IPC: C07D401/04 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/50 ,  A61K31/506 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P11/00 ,  A61P13/02 ,  A61P13/08 ,  A61P17/00 ,  A61P27/16 ,  A61P31/04 ,  A61P43/00 ,  C07C275/06 ,  C07D401/14 ,  C07D403/04 ,  C07C275/64 ,  A61K31/4427

CPC classification number: C07D401/04 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K45/06 ,  C07C275/06 ,  C07D401/14 ,  C07D403/04 ,  Y02A50/473 ,  Y02A50/478 ,  A61K2300/00

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to a method for preparing these compounds.

公开(公告)号：AU2004261545A1

公开(公告)日：2005-02-10

申请号：AU2004261545

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： WANG TIANSHENG ,  LETIRAN ARNAUD ,  DRUMM JOSEPH ,  CHARIFSON PAUL S ,  DEININGER DAVID D ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  RONKIN STEVEN M ,  STAMOS DEAN ,  PEROLA EMAUELE

IPC: A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D403/10 ,  A61K31/4184

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

公开(公告)号：CY1110230T1

公开(公告)日：2015-01-14

申请号：CY091100932

申请日：2009-09-07

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  DEININGER DAVID D ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  RONKIN STEVEN M ,  STAMOS DEAN ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  LE TIRAN ARNAUD ,  DRUMM JOSEPH

IPC: C07D491/04 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/506 ,  A61P31/00 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: Ηπαρούσαεφεύρεσησχετίζεταιμεενώσειςπουαναστέλλουνβακτηριακήγυράσηκαι/ή Topo IV καιφαρμακευτικώςαποδεκτέςσυνθέσειςπουπεριλαμβάνουντιςπροαναφερθείσεςενώσεις. Αυτέςοιενώσεις, καισυνθέσειςαυτών, είναιχρήσιμεςστηναντιμετώπισηβακτηριακήςλοίμωξης. Σύμφωναμεαυτά, ηπαρούσαεφεύρεσηεπίσηςσχετίζεταιμεμεθόδουςγιατηναντιμετώπισηβακτηριακώνλοιμώξεωνσεθηλαστικά.

公开(公告)号：PT1592686E

公开(公告)日：2009-08-25

申请号：PT04775744

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： DEININGER DAVID D ,  STAMOS DEAN ,  CHARIFSON PAUL S ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  RONKIN STEVEN M ,  PEROLA EMAUELE ,  WANG TIANSHENG ,  TIRAN ARNAUD LE ,  DRUMM JOSEPH

IPC: C07D403/14 ,  A61K31/4184 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

公开(公告)号：AT433980T

公开(公告)日：2009-07-15

申请号：AT04810009

申请日：2004-10-21

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  DEININGER DAVID ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  RONKIN STEVEN ,  STAMOS DEAN ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  LE TIRAN ARNAUD ,  DRUMM JOSEPH

IPC: C07D491/04 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/506 ,  A61P31/00 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

公开(公告)号：MXPA05008126A

公开(公告)日：2006-03-30

申请号：MXPA05008126

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： DRUMM JOSEPH

IPC: A61K31/4184 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

Abstract: La presente invencion se relaciona con compuestos que inhiben la girasa bacteriana y/o la Topo IV y con las composiciones farmaceuticamente aceptables que comprenden los compuestos. Estos compuestos, y las composiciones de los mismos, son utiles para tratar infecciones bacterianas. Por consiguiente, la presente invencion tambien se relaciona con los metodos para tratar infecciones bacterianas en mamiferos. Formula (I). (ver formula (I)).