公开(公告)号：WO02102381A9

公开(公告)日：2003-03-06

申请号：PCT/US0218999

申请日：2002-06-13

Applicant: VERTEX PHARMA ,  LAUFFER DAVID ,  TOMLINSON RONALD ,  OTTOW ECKARD ,  BOTFIELD MARTYN

Inventor： LAUFFER DAVID ,  TOMLINSON RONALD ,  OTTOW ECKARD ,  BOTFIELD MARTYN

IPC: C07D295/18 ,  A61K31/445 ,  A61K31/495 ,  A61K45/00 ,  A61P3/10 ,  A61P9/10 ,  A61P19/00 ,  A61P19/02 ,  A61P21/00 ,  A61P21/04 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07B61/00 ,  C07D211/16 ,  C07D295/185 ,  C07D241/04

CPC classification number: C07D295/185 ,  C07D211/16 ,  C40B40/00

Abstract: The present invention relates to acyclic piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.

Abstract translation: 本发明涉及无环哌嗪和哌啶衍生物，其特别可用于治疗或预防神经元损伤，特别是与神经疾病相关的损伤。 这些化合物也可用于刺激神经生长。 本发明还提供包含本发明化合物的组合物和利用这些组合物治疗或预防神经元损伤或刺激神经生长的方法。

公开(公告)号：MXPA05003471A

公开(公告)日：2005-07-01

申请号：MXPA05003471

申请日：2003-10-02

Applicant: VERTEX PHARMA

Inventor： OTTOW ECKARD

IPC: A61P25/28 ,  C07D207/16 ,  C07D211/60 ,  A61K31/496

Abstract: La presente invencion se relaciona con derivados de piperazina y piperidina, que son especialmente utiles para tratar o prevenir el dano neuronal, particularmente el dano asociado con enfermedades neurologicas. Estos compuestos tambien son utiles para estimular el crecimiento del tejido nervioso. La invencion tambien proporciona composiciones que contienen los compuestos de la presente invencion y metodos para utilizar estas composiciones para tratar o prevenir dano neuronal al estimular el crecimiento del tejido nervioso.

公开(公告)号：CA2450074A1

公开(公告)日：2002-12-27

申请号：CA2450074

申请日：2002-06-13

Applicant: VERTEX PHARMA

Inventor： BOTFIELD MARTYN ,  TOMLINSON RONALD ,  OTTOW ECKARD ,  LAUFFER DAVID

IPC: C07D295/18 ,  A61K31/445 ,  A61K31/495 ,  A61K45/00 ,  A61P3/10 ,  A61P9/10 ,  A61P19/00 ,  A61P19/02 ,  A61P21/00 ,  A61P21/04 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07B61/00 ,  C07D211/16 ,  C07D295/185 ,  C07D241/04 ,  A61K31/395 ,  A61K31/496

Abstract: The present invention relates to acyclic piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.