公开(公告)号：WO2011009084A2

公开(公告)日：2011-01-20

申请号：PCT/US2010042340

申请日：2010-07-16

Applicant: VERTEX PHARMA ,  HENDERSON JAMES A ,  MAXWELL JOHN ,  VAILLANCOURT LOUIS ,  MORRIS MARK ,  GREY JR RONALD ,  GIROUX SIMON ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  LIU BINGCAN ,  POISSON CARL ,  CADILHAC CAROLINE ,  BUBENIK MONICA ,  REDDY T JAGADEESWAR ,  FALARDEAU GUY ,  YANNOPOULOS CONSTANTIN ,  WANG JIAN ,  PEREIRA OSWY Z ,  BENNANI YOUSSEF L ,  PIERCE ALBERT C ,  BHISETTI GOVINDA RAO ,  COTTRELL KEVIN M ,  MARONE VALERIE

Inventor： HENDERSON JAMES A ,  MAXWELL JOHN ,  VAILLANCOURT LOUIS ,  MORRIS MARK ,  GREY JR RONALD ,  GIROUX SIMON ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  LIU BINGCAN ,  POISSON CARL ,  CADILHAC CAROLINE ,  BUBENIK MONICA ,  REDDY T JAGADEESWAR ,  FALARDEAU GUY ,  YANNOPOULOS CONSTANTIN ,  WANG JIAN ,  PEREIRA OSWY Z ,  BENNANI YOUSSEF L ,  PIERCE ALBERT C ,  BHISETTI GOVINDA RAO ,  COTTRELL KEVIN M ,  MARONE VALERIE

IPC: C07D403/14 ,  A61K31/506

CPC classification number: C07K5/06052 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

Abstract: Compounds represented by formula (I) or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B', X, Y, R1, R1 ', R2, R2', R3, R3', R5, R5', R6, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

Abstract translation: 其中A，B，B'，X，Y，R1，R1'，R2，R2'，R3，R3'，R5，R5'，R6，m ，n或p如本文所定义，可用于治疗黄病毒科病毒感染。

公开(公告)号：WO2012024363A3

公开(公告)日：2012-05-31

申请号：PCT/US2011048027

申请日：2011-08-17

Applicant: VERTEX PHARMA ,  GREEN JEREMY ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  POISSON CARL ,  NANTHAKUMAR SUGANTHINI ,  WAAL NATHAN ,  LI PAN ,  RONKIN STEVEN ,  LAUFFER DAVID J ,  WILSON DEAN M

Inventor： GREEN JEREMY ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  POISSON CARL ,  NANTHAKUMAR SUGANTHINI ,  WAAL NATHAN ,  LI PAN ,  RONKIN STEVEN ,  LAUFFER DAVID J ,  WILSON DEAN M

IPC: C07D333/38 ,  A61K31/381 ,  A61P31/12 ,  C07D333/40 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

CPC classification number: A61K31/427 ,  A61K31/381 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/4436 ,  A61K31/4535 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/7056 ,  A61K38/212 ,  C07D333/38 ,  C07D333/40 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: A compound is selected from the structural formulae depicted in FIG. 1 or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound selected from the structural formulae depicted in FIG. 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier of excipient. A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of selected from the structural formulae depicted in FIG. 1 or a pharmaceutically acceptable salt thereof. A method of inhibiting or reducing the activity of HCV polymerase in a subject or in a biological in vitro sample comprises administering to the subject or to the sample a therapeutically effective amount of selected from the structural formulae depicted in FIG. 1 or a pharmaceutically acceptable salt thereof.

Abstract translation: 化合物选自图1中所示的结构式。 1或其药学上可接受的盐。 药物组合物包含选自图1中描绘的结构式的化合物。 1或其药学上可接受的盐和赋形剂的药学上可接受的载体。 治疗受试者的HCV感染的方法包括向受试者施用治疗有效量的选自图1中描述的结构式的治疗有效量的化合物。 1或其药学上可接受的盐。 抑制或降低受试者中或生物体外样品中HCV聚合酶活性的方法包括向受试者或样品施用治疗有效量的选自图1中描述的结构式的治疗有效量。 1或其药学上可接受的盐。

公开(公告)号：WO2014165107A2

公开(公告)日：2014-10-09

申请号：PCT/US2014024411

申请日：2014-03-12

Applicant: VERTEX PHARMA

Inventor： DIETRICH EVELYNE ,  POISSON CARL ,  GALLANT MICHEL ,  LESSARD STEPHANIE ,  LIU BINGCAN ,  DAS SANJOY KUMAR ,  RAMTOHUL YEEMAN ,  REDDY THUMKUNTA JAGADEESWAR ,  MARTEL JULIEN ,  VALLEE FREDERIC ,  LEVESQUE JEAN-FRANCOIS

IPC: C07H15/26 ,  C07D493/10 ,  C07H15/207 ,  C07H15/22

CPC classification number: C07D493/10 ,  C07H15/18 ,  C07H15/20 ,  C07H15/203 ,  C07H15/207 ,  C07H15/22

Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula (I) The invention also provides processes for making the compounds described herein. Furthermore, the present invention provides a composition comprising the compounds described herein, and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The present invention also provides methods of treating or preventing bacteria infection in a subject, comprising administering to the subject an effective amount of the compound or the composition described herein.

Abstract translation: 本发明涉及可用于治疗或预防细菌感染的化合物。 这些化合物具有式（I）本发明还提供了制备本文所述化合物的方法。 此外，本发明提供包含本文所述化合物和药学上可接受的载体，佐剂或载体的组合物。 本发明还提供了治疗或预防受试者细菌感染的方法，包括给予受试者有效量的本文所述的化合物或组合物。

公开(公告)号：WO2012006055A3

公开(公告)日：2012-03-01

申请号：PCT/US2011042110

申请日：2011-06-28

Applicant: VERTEX PHARMA ,  GREEN JEREMY ,  WILSON DEAN M ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  POISSON CARL ,  COURT JOHN J ,  TANG QING ,  LI PAN ,  COLLIER PHILIP N ,  WAAL NATHAN ,  LAUFFER DAVID J ,  DORSCH WARREN

Inventor： GREEN JEREMY ,  WILSON DEAN M ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  POISSON CARL ,  COURT JOHN J ,  TANG QING ,  LI PAN ,  COLLIER PHILIP N ,  WAAL NATHAN ,  LAUFFER DAVID J ,  DORSCH WARREN

IPC: C07D333/40 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4535 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  A61P31/12 ,  C07D409/12 ,  C07D413/12 ,  C07D491/08

CPC classification number: C07D413/12 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4535 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D491/08 ,  C07D491/10

Abstract: A compound is represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and the claims. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier of excipient. A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of inhibiting or reducing the activity of HCV polymerase in a subject or in a biological in vitro sample comprises administering to the subject or to the sample a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract translation: 化合物由结构式（I）或其药学上可接受的盐表示，其中结构式（I）的变量如说明书和权利要求书中所述。 药物组合物包含由结构式（I）表示的化合物或其药学上可接受的盐和赋形剂的药学上可接受的载体。 治疗受试者HCV感染的方法包括向受试者施用治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐。 抑制或降低受试者或生物体外样品中HCV聚合酶活性的方法包括向受试者或样品施用治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐 。

公开(公告)号：DK2935302T3

公开(公告)日：2018-08-13

申请号：DK13818136

申请日：2013-12-18

Applicant: VERTEX PHARMA

Inventor： RAMTOHUL YEEMAN K ,  DAS SANJOY KUMAR ,  CADILHAC CAROLINE ,  REDDY THUMKUNTA JAGADEESWAR ,  VAILLANCOURT LOUIS ,  GALLANT MICHEL ,  LIU BINGCAN ,  DIETRICH EVELYNE ,  VALLEE FREDERIC ,  MARTEL JULIEN ,  POISSON CARL

IPC: C07H15/26 ,  A61K31/335 ,  A61K31/381 ,  A61K31/385 ,  A61K31/40 ,  A61K31/433 ,  A61K31/502 ,  A61K31/517 ,  A61K31/7048 ,  A61K31/7056 ,  C07D309/10 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04 ,  C07H19/056

公开(公告)号：CA2905019A1

公开(公告)日：2014-10-09

申请号：CA2905019

申请日：2014-03-12

Applicant: VERTEX PHARMA

Inventor： DIETRICH EVELYNE ,  POISSON CARL ,  GALLANT MICHEL ,  LESSARD STEPHANIE ,  LIU BINGCAN ,  DAS SANJOY KUMAR ,  RAMTOHUL YEEMAN ,  REDDY THUMKUNTA JAGADEESWAR ,  MARTEL JULIEN ,  VALLEE FREDERIC ,  LEVESQUE JEAN-FRANCOIS

IPC: C07H15/18 ,  A61K31/7034 ,  C07D493/10 ,  C07H15/20 ,  C07H15/207 ,  C07H15/22

Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula (I) The invention also provides processes for making the compounds described herein. Furthermore, the present invention provides a composition comprising the compounds described herein, and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The present invention also provides methods of treating or preventing bacteria infection in a subject, comprising administering to the subject an effective amount of the compound or the composition described herein.

公开(公告)号：MX2012006026A

公开(公告)日：2012-08-15

申请号：MX2012006026

申请日：2010-11-23

Applicant: VERTEX PHARMA

Inventor： DAS SANJOY KUMAR ,  KONG LAVAL CHAN CHUN ,  POISSON CARL

IPC: C07D333/38 ,  A61K31/381 ,  C07D409/12

Abstract: Los compuestos representados por la Fórmula I : (VER FÓRMULA). O las sales farmacéuticamente aceptables de estos, en donde R¹, R², y R³ son como se definieron en la presente, son útiles para tratar las infecciones virales por Flaviviridae.

公开(公告)号：AU2010336355A1

公开(公告)日：2012-07-05

申请号：AU2010336355

申请日：2010-12-27

Applicant: VERTEX PHARMA

Inventor： LIU BINGCAN ,  POISSON CARL ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  YANNOPOULOS CONSTANTIN ,  CADILHAC CAROLINE ,  REDDY T JAGADEERSWAR ,  VAIILLANCOURT LOUIS ,  FALARDEAU GUY ,  PEREIRA OSWY W ,  BUBENIK MONICA ,  MAXWELL JOHN

IPC: C07D403/14 ,  A61K31/4155 ,  A61P31/14

Abstract: Compounds represented by Formula I: (I) or pharmaceutically acceptable salts thereof, wherein A, B, B', X, Y, R1, R, R', R, R', R R', R R'm, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

公开(公告)号：CA2894536C

公开(公告)日：2020-07-28

申请号：CA2894536

申请日：2013-12-18

Applicant: VERTEX PHARMA

Inventor： RAMTOHUL YEEMAN K ,  CADILHAC CAROLINE ,  DAS SANJOY KUMAR ,  DIETRICH EVELYNE ,  GALLANT MICHEL ,  LIU BINGCAN ,  MARTEL JULIEN ,  POISSON CARL ,  REDDY THUMKUNTA JAGADEESWAR ,  VAILLANCOURT LOUIS ,  VALLEE FREDERIC

IPC: C07H15/26 ,  A61K31/335 ,  A61K31/381 ,  A61K31/385 ,  A61K31/40 ,  A61K31/4192 ,  A61K31/421 ,  A61K31/433 ,  A61K31/50 ,  A61K31/502 ,  A61K31/505 ,  A61K31/517 ,  A61K31/7048 ,  A61K31/7056 ,  C07H19/056

Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula (I). The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.

公开(公告)号：PL2935302T3

公开(公告)日：2018-12-31

申请号：PL13818136

申请日：2013-12-18

Applicant: VERTEX PHARMA

Inventor： RAMTOHUL YEEMAN K ,  DAS SANJOY KUMAR ,  CADILHAC CAROLINE ,  REDDY THUMKUNTA JAGADEESWAR ,  VAILLANCOURT LOUIS ,  GALLANT MICHEL ,  LIU BINGCAN ,  DIETRICH EVELYNE ,  VALLEE FREDERIC ,  MARTEL JULIEN ,  POISSON CARL

IPC: C07H15/26 ,  A61K31/335 ,  A61K31/381 ,  A61K31/385 ,  A61K31/40 ,  A61K31/433 ,  A61K31/502 ,  A61K31/517 ,  A61K31/7048 ,  A61K31/7056 ,  C07D309/10 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04 ,  C07H19/056