公开(公告)号：WO2011009084A2

公开(公告)日：2011-01-20

申请号：PCT/US2010042340

申请日：2010-07-16

Applicant: VERTEX PHARMA ,  HENDERSON JAMES A ,  MAXWELL JOHN ,  VAILLANCOURT LOUIS ,  MORRIS MARK ,  GREY JR RONALD ,  GIROUX SIMON ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  LIU BINGCAN ,  POISSON CARL ,  CADILHAC CAROLINE ,  BUBENIK MONICA ,  REDDY T JAGADEESWAR ,  FALARDEAU GUY ,  YANNOPOULOS CONSTANTIN ,  WANG JIAN ,  PEREIRA OSWY Z ,  BENNANI YOUSSEF L ,  PIERCE ALBERT C ,  BHISETTI GOVINDA RAO ,  COTTRELL KEVIN M ,  MARONE VALERIE

Inventor： HENDERSON JAMES A ,  MAXWELL JOHN ,  VAILLANCOURT LOUIS ,  MORRIS MARK ,  GREY JR RONALD ,  GIROUX SIMON ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  LIU BINGCAN ,  POISSON CARL ,  CADILHAC CAROLINE ,  BUBENIK MONICA ,  REDDY T JAGADEESWAR ,  FALARDEAU GUY ,  YANNOPOULOS CONSTANTIN ,  WANG JIAN ,  PEREIRA OSWY Z ,  BENNANI YOUSSEF L ,  PIERCE ALBERT C ,  BHISETTI GOVINDA RAO ,  COTTRELL KEVIN M ,  MARONE VALERIE

IPC: C07D403/14 ,  A61K31/506

CPC classification number: C07K5/06052 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

Abstract: Compounds represented by formula (I) or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B', X, Y, R1, R1 ', R2, R2', R3, R3', R5, R5', R6, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

Abstract translation: 其中A，B，B'，X，Y，R1，R1'，R2，R2'，R3，R3'，R5，R5'，R6，m ，n或p如本文所定义，可用于治疗黄病毒科病毒感染。

公开(公告)号：BR112015014458B1

公开(公告)日：2022-06-21

申请号：BR112015014458

申请日：2013-12-18

Applicant: VERTEX PHARMA

Inventor： LIU BINGCAN ,  POISSON CARL ,  CADILHAC CAROLINE ,  DIETRICH EVELYNE ,  VALLEE FREDERIC ,  MARTEL JULIEN ,  VAILLANCOURT LOUIS ,  GALLANT MICHEL ,  SANJOY KUMAR DAS ,  THUMKUNTA JAGADEESWAR REDDY ,  YEEMAN K RAMTOHUL

IPC: A61K31/335 ,  A61K31/381 ,  A61K31/385 ,  A61K31/40 ,  A61K31/4192 ,  A61K31/421 ,  A61K31/433 ,  A61K31/50 ,  A61K31/502 ,  A61K31/505 ,  A61K31/517 ,  A61K31/7048 ,  A61K31/7056 ,  C07H15/26 ,  C07H19/056

Abstract: compostos derivados de manose, seus intermediários, composição, uso e processos de preparação. a presente invenção refere-se a compostos úteis para o tratamento ou prevenção de infecções por bactérias. estes compostos têm a fórmula (i). a invenção também fornece composições farmaceuticamente aceitáveis contendo os compostos e métodos de uso das composições no tratamento de infecções por bactérias. finalmente, a invenção fornece processos para a preparação de compostos da invenção. fórmula i

公开(公告)号：CA2767887A1

公开(公告)日：2011-01-20

申请号：CA2767887

申请日：2010-07-16

Applicant: VERTEX PHARMA

Inventor： HENDERSON JAMES A ,  MAXWELL JOHN ,  VAILLANCOURT LOUIS ,  MORRIS MARK ,  GREY RONALD JR ,  GIROUX SIMON ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  LIU BINGCAN ,  POISSON CARL ,  CADILHAC CAROLINE ,  BUBENIK MONICA ,  REDDY T JAGADEESWAR ,  FALARDEAU GUY ,  YANNOPOULOS CONSTANTIN ,  WANG JIAN ,  PEREIRA OSWY Z ,  BENNANI YOUSSEF L ,  PIERCE ALBERT C ,  BHISETTI GOVINDA RAO ,  COTTRELL KEVIN M ,  MARONE VALERIE

IPC: C07D403/14 ,  A61K31/4184 ,  A61K31/506 ,  A61P3/00 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

Abstract: Compounds represented by formula (I) or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B', X, Y, R1, R1 ', R2, R2', R3, R3', R5, R5', R6, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

公开(公告)号：DK2935302T3

公开(公告)日：2018-08-13

申请号：DK13818136

申请日：2013-12-18

Applicant: VERTEX PHARMA

Inventor： RAMTOHUL YEEMAN K ,  DAS SANJOY KUMAR ,  CADILHAC CAROLINE ,  REDDY THUMKUNTA JAGADEESWAR ,  VAILLANCOURT LOUIS ,  GALLANT MICHEL ,  LIU BINGCAN ,  DIETRICH EVELYNE ,  VALLEE FREDERIC ,  MARTEL JULIEN ,  POISSON CARL

IPC: C07H15/26 ,  A61K31/335 ,  A61K31/381 ,  A61K31/385 ,  A61K31/40 ,  A61K31/433 ,  A61K31/502 ,  A61K31/517 ,  A61K31/7048 ,  A61K31/7056 ,  C07D309/10 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04 ,  C07H19/056

公开(公告)号：AU2010336355A1

公开(公告)日：2012-07-05

申请号：AU2010336355

申请日：2010-12-27

Applicant: VERTEX PHARMA

Inventor： LIU BINGCAN ,  POISSON CARL ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  YANNOPOULOS CONSTANTIN ,  CADILHAC CAROLINE ,  REDDY T JAGADEERSWAR ,  VAIILLANCOURT LOUIS ,  FALARDEAU GUY ,  PEREIRA OSWY W ,  BUBENIK MONICA ,  MAXWELL JOHN

IPC: C07D403/14 ,  A61K31/4155 ,  A61P31/14

Abstract: Compounds represented by Formula I: (I) or pharmaceutically acceptable salts thereof, wherein A, B, B', X, Y, R1, R, R', R, R', R R', R R'm, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

公开(公告)号：CA2894536C

公开(公告)日：2020-07-28

申请号：CA2894536

申请日：2013-12-18

Applicant: VERTEX PHARMA

Inventor： RAMTOHUL YEEMAN K ,  CADILHAC CAROLINE ,  DAS SANJOY KUMAR ,  DIETRICH EVELYNE ,  GALLANT MICHEL ,  LIU BINGCAN ,  MARTEL JULIEN ,  POISSON CARL ,  REDDY THUMKUNTA JAGADEESWAR ,  VAILLANCOURT LOUIS ,  VALLEE FREDERIC

IPC: C07H15/26 ,  A61K31/335 ,  A61K31/381 ,  A61K31/385 ,  A61K31/40 ,  A61K31/4192 ,  A61K31/421 ,  A61K31/433 ,  A61K31/50 ,  A61K31/502 ,  A61K31/505 ,  A61K31/517 ,  A61K31/7048 ,  A61K31/7056 ,  C07H19/056

Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula (I). The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.

公开(公告)号：PL2935302T3

公开(公告)日：2018-12-31

申请号：PL13818136

申请日：2013-12-18

Applicant: VERTEX PHARMA

Inventor： RAMTOHUL YEEMAN K ,  DAS SANJOY KUMAR ,  CADILHAC CAROLINE ,  REDDY THUMKUNTA JAGADEESWAR ,  VAILLANCOURT LOUIS ,  GALLANT MICHEL ,  LIU BINGCAN ,  DIETRICH EVELYNE ,  VALLEE FREDERIC ,  MARTEL JULIEN ,  POISSON CARL

IPC: C07H15/26 ,  A61K31/335 ,  A61K31/381 ,  A61K31/385 ,  A61K31/40 ,  A61K31/433 ,  A61K31/502 ,  A61K31/517 ,  A61K31/7048 ,  A61K31/7056 ,  C07D309/10 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04 ,  C07H19/056

公开(公告)号：CL2015001667A1

公开(公告)日：2016-01-15

申请号：CL2015001667

申请日：2015-06-15

Applicant: VERTEX PHARMA

Inventor： RAMTOHUL YEEMAN K ,  DAS SANJOY KUMAR ,  CADILHAC CAROLINE ,  REDDY THUMKUNTA JAGADEESWAR ,  VAILLANCOURT LOUIS ,  GALLANT MICHEL ,  LIU BINGCAN ,  DIETRICH EVELYNE ,  VALLEE FREDERIC ,  MARTEL JULIEN ,  POISSON CARL

IPC: C07H15/26 ,  A61K31/7048 ,  A61K31/7056 ,  A61P31/04 ,  C07H19/056

Abstract: COMPUESTOS DERIVADOS DE MANOSA O SUS SALES FARMACEUTICAMENTE ACEPTABLES; PROCESO DE PREPARACION DE DICHOS COMPUESTOS; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE, UTIL PARA TRATAR O PREVENIR UNA INFECCION BACTERIANA.

公开(公告)号：SG11201504813XA

公开(公告)日：2015-07-30

申请号：SG11201504813X

申请日：2013-12-18

Applicant: VERTEX PHARMA

Inventor： RAMTOHUL YEEMAN K ,  DAS SANJOY KUMAR ,  CADILHAC CAROLINE ,  REDDY THUMKUNTA JAGADEESWAR ,  VAILLANCOURT LOUIS ,  GALLANT MICHEL ,  LIU BINGCAN ,  DIETRICH EVELYNE ,  VALLEE FREDERIC ,  MARTEL JULIEN ,  POISSON CARL

IPC: C07H15/26 ,  A61K31/335 ,  A61K31/381 ,  A61K31/385 ,  A61K31/40 ,  A61K31/4192 ,  A61K31/421 ,  A61K31/433 ,  A61K31/50 ,  A61K31/502 ,  A61K31/505 ,  A61K31/517 ,  A61K31/7048 ,  A61K31/7056 ,  C07H19/056

Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: wherein Z is

公开(公告)号：AU2013361602A1

公开(公告)日：2015-07-02

申请号：AU2013361602

申请日：2013-12-18

Applicant: VERTEX PHARMA

Inventor： RAMTOHUL YEEMAN K ,  DAS SANJOY KUMAR ,  CADILHAC CAROLINE ,  REDDY THUMKUNTA JAGADEESWAR ,  VAILLANCOURT LOUIS ,  GALLANT MICHEL ,  LIU BINGCAN ,  DIETRICH EVELYNE ,  VALLEE FREDERIC ,  MARTEL JULIEN ,  POISSON CARL

IPC: C07H15/26 ,  A61K31/335 ,  A61K31/381 ,  A61K31/385 ,  A61K31/40 ,  A61K31/4192 ,  A61K31/421 ,  A61K31/433 ,  A61K31/50 ,  A61K31/502 ,  A61K31/505 ,  A61K31/517 ,  A61K31/7048 ,  A61K31/7056 ,  C07H19/056

Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula (I). The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.