公开(公告)号：WO2015134317A8

公开(公告)日：2015-11-26

申请号：PCT/US2015017972

申请日：2015-02-27

Applicant: WATERS TECHNOLOGIES CORP

Inventor： BROUSMICHE DARRYL W ,  FAIRCHILD JACOB N ,  HILL JASON F ,  ISAAC GIORGIS ,  MORRIS MICHAEL F ,  WYNDHAM KEVIN D

IPC: B01D15/08 ,  B01D15/26 ,  B01J20/32

CPC classification number: B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3234 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/80 ,  C07F7/1836

Abstract: The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.

Abstract translation: 本公开涉及将目的化合物，特别是目标的不饱和化合物与混合物分离的方法。 使用具有色谱固定相材料的色谱柱分离化合物，用于各种不同的含有第一取代基和第二取代基的不同色谱方式。 在色谱条件下，第一取代基使化合物保留时间变化最小化。 第二取代基通过引入一个或多个芳族，多芳族，杂环芳族或多杂环芳族烃基来色谱和选择性地保留化合物，每个基团任选被脂族基团取代。

公开(公告)号：DE112013002532T5

公开(公告)日：2015-03-12

申请号：DE112013002532

申请日：2013-05-15

Applicant: WATERS TECHNOLOGIES CORP

Inventor： WYNDHAM KEVIN D ,  MORRIS MICHAEL F ,  BROUSMICHE DARRYL W ,  FAIRCHILD JACOB N

IPC: B01D15/26 ,  B01J20/32

Abstract: In einem Aspekt stellt die vorliegende Erfindung ein chromatographisches stationäre Phasen-Material für verschiedene Chromatographie-Methoden bereit, dargestellt durch die Formel 1: [X](W)a(Q)b(T)c (Formel 1). X kann eine hochreine chromatographische Kernzusammensetzung sein, umfassend Kieselerde-Kernmaterial, Metalloxid-Kernmaterial, ein anorganisch-organisches Hybridmaterial oder eine Gruppe von Blockcopolymeren davon. W kann fehlen und/oder kann einen Wasserstoff umfassen und/oder kann Hydroxyl an der Oberfläche von X umfassen. Q kann eine funktionelle Gruppe sein, die die Retentionsschwankung im zeitlichen Verlauf (Drift) unter chromatographischen Bedingungen bei Verwendung von geringen Wasserkonzentrationen minimiert. T kann eine oder mehrere hydrophile, polare, ionisierbare und/oder geladene funktionelle Gruppen umfassen, die mit dem Analyten chromatographisch interagieren. Außerdem können b und c positive Zahlen sein, wobei das Verhältnis 0,05 ≤ (b/c) ≤ 100 lautet und a ≥ 0.

公开(公告)号：WO2013173501A3

公开(公告)日：2014-03-06

申请号：PCT/US2013041221

申请日：2013-05-15

Applicant: WATERS TECHNOLOGIES CORP

Inventor： WYNDHAM KEVIN D ,  MORRIS MICHAEL F ,  BROUSMICHE DARRYL W ,  HILL JASON F ,  FAIRCHILD JACOB N

IPC: B01D15/26 ,  B01J20/32

CPC classification number: B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3234 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/80 ,  C07F7/1836

Abstract: In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1:[X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05 = 0.

Abstract translation: 一方面，本发明提供了用于由式1表示的各种不同色谱方式的色谱固定相材料：[X]（W）a（Q）b（T）c（式1）。 X可以是具有包含二氧化硅芯材料，金属氧化物芯材料，无机 - 有机杂化材料或其一组嵌段共聚物的表面的高纯度色谱芯组合物。 W可以不存在和/或可以包括氢和/或可以在X的表面上包括羟基.Q可以是在使用低水浓度的色谱条件下最小化随时间（漂移）的保留变化的官能团。 T可以包括与分析物色谱相互作用的一个或多个亲水性，极性的，可离子化的和/或带电的官能团。 另外，b和c可以是正数，0.05 <=（b / c）<= 100，a> = 0。

公开(公告)号：WO2015134317A9

公开(公告)日：2016-08-04

申请号：PCT/US2015017972

申请日：2015-02-27

Applicant: WATERS TECHNOLOGIES CORP

Inventor： BROUSMICHE DARRYL W ,  FAIRCHILD JACOB N ,  HILL JASON F ,  ISAAC GIORGIS ,  MORRIS MICHAEL F ,  WYNDHAM KEVIN D

IPC: B01D15/08 ,  B01D15/26 ,  B01J20/32

CPC classification number: B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3234 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/80 ,  C07F7/1836

Abstract: The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.

Abstract translation: 本公开内容涉及将目的化合物，特别是目标的不饱和化合物从混合物中分离出来的方法。 使用具有色谱固定相材料的柱分离化合物，用于各种不同的含有第一取代基和第二取代基的不同色谱模式。 在色谱条件下，第一取代基使化合物保留时间变化最小化。 第二取代基通过引入一个或多个芳族，多芳族，杂环芳族或多杂环芳族烃基来色谱和选择性地保留化合物，每个基团任选被脂族基团取代。

公开(公告)号：WO2013173501A8

公开(公告)日：2014-10-09

申请号：PCT/US2013041221

申请日：2013-05-15

Applicant: WATERS TECHNOLOGIES CORP

Inventor： WYNDHAM KEVIN D ,  MORRIS MICHAEL F ,  BROUSMICHE DARRYL W ,  HILL JASON F ,  FAIRCHILD JACOB N

IPC: B01D15/26 ,  B01J20/32

CPC classification number: B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3234 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/80 ,  C07F7/1836

Abstract: In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1:[X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05 ≤ (b/c) ≤ 100, and a ≥ 0.

Abstract translation: 一方面，本发明提供了用于由式1表示的各种不同色谱方式的色谱固定相材料：[X]（W）a（Q）b（T）c（式1）。 X可以是具有包含二氧化硅芯材料，金属氧化物芯材料，无机 - 有机杂化材料或其一组嵌段共聚物的表面的高纯度色谱芯组合物。 W可以不存在和/或可以包括氢和/或可以在X的表面上包括羟基.Q可以是在使用低水浓度的色谱条件下最小化随时间（漂移）的保留变化的官能团。 T可以包括与分析物色谱相互作用的一个或多个亲水性，极性的，可离子化的和/或带电的官能团。 另外，b和c可以是正数，其比例为0.05≤（b / c）≤100，a≥0。

公开(公告)号：HK1211258A1

公开(公告)日：2016-05-20

申请号：HK15112033

申请日：2015-12-07

Applicant: WATERS TECHNOLOGIES CORP

Inventor： WYNDHAM KEVIN D ,  MORRIS MICHAEL F ,  BROUSMICHE DARRYL W ,  HILL JASON F ,  FAIRCHILD JACOB NATHAN

IPC: B01J20060101 ,  B01D20060101

Abstract: In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.

公开(公告)号：GB2521524A

公开(公告)日：2015-06-24

申请号：GB201420330

申请日：2013-05-15

Applicant: WATERS TECHNOLOGIES CORP

Inventor： WYNDHAM KEVIN D ,  MORRIS MICHAEL F ,  BROUSMICHE DARRYL W ,  HILL JASON F ,  FAIRCHILD JACOB NATHAN

IPC: B01J20/30 ,  B01D15/26 ,  B01J20/32

Abstract: In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1:[X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05 ≤ (b/c) ≤ 100, and a ≥ 0.

公开(公告)号：EP3218352A4

公开(公告)日：2018-07-18

申请号：EP15859131

申请日：2015-11-12

Applicant: WATERS TECHNOLOGIES CORP

Inventor： MORRIS MICHAEL F ,  LAUBER MATTHEW A ,  BROUSMICHE DARRYL W

IPC: C07C217/08 ,  B01D15/30 ,  C07D215/48 ,  C07H15/26 ,  G01N30/02 ,  G01N30/04 ,  G01N30/62 ,  G01N30/88 ,  G01N33/68

CPC classification number: G01N30/02 ,  B01D15/305 ,  C07D215/48 ,  C07H15/26 ,  G01N30/04 ,  G01N30/88 ,  G01N33/6842 ,  G01N2030/027 ,  G01N2030/047 ,  G01N2030/626 ,  G01N2030/8836 ,  G01N2400/00 ,  G01N2440/38

Abstract: Methods are provided for making rapid labeled dextran ladders and other calibrants useful in liquid chromatography. The methodologies include a two-step process comprising a reductive amination step of providing a reducing glycan and reacting it with a compound having a primary amine to produce an intermediate compound. The intermediate compound is then rapidly tagged with a rapid tagging reagent to produce the rapid labeled dextran ladder.

公开(公告)号：EP3113857A4

公开(公告)日：2017-11-15

申请号：EP15758913

申请日：2015-02-27

Applicant: WATERS TECHNOLOGIES CORP

Inventor： BROUSMICHE DARRYL W ,  FAIRCHILD JACOB N ,  HILL JASON F ,  ISAAC GIORGIS ,  MORRIS MICHAEL F ,  WYNDHAM KEVIN D

IPC: B01D15/08 ,  B01D15/26 ,  B01J20/32

CPC classification number: B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3234 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/80 ,  C07F7/1836

Abstract: The present invention provides a chromatographic stationary phase material various different types of chromatography. One example chromatographic stationary phase is represented by Formula 1 [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition. W can be absent and/or can include hydrogen and/or can include hydroxyl on the surface of X. Q can be bound directly to X and can include a first hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte. T can be bound directly to X and can include a second hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte. Additionally, Q and T can essentially eliminate chromatographic interaction between the analyte, and X and W, thereby minimizing retention variation over time (drift or change) under chromatographic conditions utilizing low water concentrations.

公开(公告)号：EP2598441A4

公开(公告)日：2017-08-30

申请号：EP11815055

申请日：2011-07-25

Applicant: WATERS TECHNOLOGIES CORP

Inventor： WYNDHAM KEVIN D ,  MURIITHI BEATRICE W ,  MORRIS MICHAEL F ,  LAWRENCE NICOLE L

IPC: B01J20/286 ,  B01J20/28 ,  B01J20/32 ,  C01B33/26

CPC classification number: B01J20/283 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28071 ,  B01J20/285 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3236 ,  B01J20/3257 ,  B01J20/3289 ,  B01J20/3293 ,  Y10T428/2991

Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are chromatographic materials comprising having a narrow particle size distribution.

Abstract translation: 本发明提供了新的色谱材料，例如用于色谱分离，其制备方法和含有色谱材料的分离装置; 分离装置，色谱柱和包含它们的试剂盒; 及其制备方法。 本发明的色谱材料是色谱材料。