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公开(公告)号：WO2015134317A8
公开(公告)日：2015-11-26
申请号：PCT/US2015017972
申请日：2015-02-27
Applicant: WATERS TECHNOLOGIES CORP
Inventor： BROUSMICHE DARRYL W , FAIRCHILD JACOB N , HILL JASON F , ISAAC GIORGIS , MORRIS MICHAEL F , WYNDHAM KEVIN D
CPC classification number: B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/32 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3234 , B01J20/3246 , B01J20/3285 , B01J20/3293 , B01J2220/54 , B01J2220/80 , C07F7/1836
Abstract: The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.
Abstract translation: 本公开涉及将目的化合物，特别是目标的不饱和化合物与混合物分离的方法。 使用具有色谱固定相材料的色谱柱分离化合物，用于各种不同的含有第一取代基和第二取代基的不同色谱方式。 在色谱条件下，第一取代基使化合物保留时间变化最小化。 第二取代基通过引入一个或多个芳族，多芳族，杂环芳族或多杂环芳族烃基来色谱和选择性地保留化合物，每个基团任选被脂族基团取代。
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公开(公告)号：DE112013002532T5
公开(公告)日：2015-03-12
申请号：DE112013002532
申请日：2013-05-15
Applicant: WATERS TECHNOLOGIES CORP
Inventor： WYNDHAM KEVIN D , MORRIS MICHAEL F , BROUSMICHE DARRYL W , FAIRCHILD JACOB N
Abstract: In einem Aspekt stellt die vorliegende Erfindung ein chromatographisches stationäre Phasen-Material für verschiedene Chromatographie-Methoden bereit, dargestellt durch die Formel 1: [X](W)a(Q)b(T)c (Formel 1). X kann eine hochreine chromatographische Kernzusammensetzung sein, umfassend Kieselerde-Kernmaterial, Metalloxid-Kernmaterial, ein anorganisch-organisches Hybridmaterial oder eine Gruppe von Blockcopolymeren davon. W kann fehlen und/oder kann einen Wasserstoff umfassen und/oder kann Hydroxyl an der Oberfläche von X umfassen. Q kann eine funktionelle Gruppe sein, die die Retentionsschwankung im zeitlichen Verlauf (Drift) unter chromatographischen Bedingungen bei Verwendung von geringen Wasserkonzentrationen minimiert. T kann eine oder mehrere hydrophile, polare, ionisierbare und/oder geladene funktionelle Gruppen umfassen, die mit dem Analyten chromatographisch interagieren. Außerdem können b und c positive Zahlen sein, wobei das Verhältnis 0,05 ≤ (b/c) ≤ 100 lautet und a ≥ 0.
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公开(公告)号：WO2013173501A3
公开(公告)日：2014-03-06
申请号：PCT/US2013041221
申请日：2013-05-15
Applicant: WATERS TECHNOLOGIES CORP
Inventor： WYNDHAM KEVIN D , MORRIS MICHAEL F , BROUSMICHE DARRYL W , HILL JASON F , FAIRCHILD JACOB N
CPC classification number: B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/32 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3234 , B01J20/3246 , B01J20/3285 , B01J20/3293 , B01J2220/54 , B01J2220/80 , C07F7/1836
Abstract: In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1:[X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05 = 0.
Abstract translation: 一方面，本发明提供了用于由式1表示的各种不同色谱方式的色谱固定相材料：[X]（W）a（Q）b（T）c（式1）。 X可以是具有包含二氧化硅芯材料，金属氧化物芯材料，无机 - 有机杂化材料或其一组嵌段共聚物的表面的高纯度色谱芯组合物。 W可以不存在和/或可以包括氢和/或可以在X的表面上包括羟基.Q可以是在使用低水浓度的色谱条件下最小化随时间（漂移）的保留变化的官能团。 T可以包括与分析物色谱相互作用的一个或多个亲水性，极性的，可离子化的和/或带电的官能团。 另外，b和c可以是正数，0.05 <=（b / c）<= 100，a> = 0。
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公开(公告)号：WO2013173494A4
公开(公告)日：2014-02-06
申请号：PCT/US2013041207
申请日：2013-05-15
Applicant: WATERS TECHNOLOGIES CORP
Inventor： BROUSMICHE DARRYL W , WYNDHAM KEVIN D , FAIRCHILD JACOB N , IRANETA PAMELA C , HILL JASON F
CPC classification number: B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/32 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3234 , B01J20/3246 , B01J20/3285 , B01J20/3293 , B01J2220/54 , B01J2220/80 , C07F7/1836
Abstract: The present invention provides a chromatographic stationary phase material various different types of chromatography. One example chromatographic stationary phase is represented by Formula 1 [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition. W can be absent and/or can include hydrogen and/or can include hydroxyl on the surface of X. Q can be bound directly to X and can include a first hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte. T can be bound directly to X and can include a second hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte. Additionally, Q and T can essentially eliminate chromatographic interaction between the analyte, and X and W, thereby minimizing retention variation over time (drift or change) under chromatographic conditions utilizing low water concentrations.
Abstract translation: 本发明提供了各种不同类型的色谱法的色谱固定相材料。 一个实例的色谱固定相由式1 [X]（W）a（Q）b（T）c（式1）表示。 X可以是高纯度色谱芯组成。 W可以不存在和/或可以包括氢和/或可以在X的表面上包括羟基.Q可以直接结合X，并且可以包括第一亲水，极性，可离子化和/或带电的官能团，其与色谱相互作用 分析物。 T可以直接与X结合，并且可以包括与分析物色谱相互作用的第二亲水，极性，可离子化和/或带电的官能团。 此外，Q和T基本上可以消除分析物与X和W之间的色谱相互作用，从而尽可能减少使用低水浓度的色谱条件下随时间的滞留变化（漂移或变化）。
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公开(公告)号：WO2015134317A9
公开(公告)日：2016-08-04
申请号：PCT/US2015017972
申请日：2015-02-27
Applicant: WATERS TECHNOLOGIES CORP
Inventor： BROUSMICHE DARRYL W , FAIRCHILD JACOB N , HILL JASON F , ISAAC GIORGIS , MORRIS MICHAEL F , WYNDHAM KEVIN D
CPC classification number: B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/32 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3234 , B01J20/3246 , B01J20/3285 , B01J20/3293 , B01J2220/54 , B01J2220/80 , C07F7/1836
Abstract: The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.
Abstract translation: 本公开内容涉及将目的化合物，特别是目标的不饱和化合物从混合物中分离出来的方法。 使用具有色谱固定相材料的柱分离化合物，用于各种不同的含有第一取代基和第二取代基的不同色谱模式。 在色谱条件下，第一取代基使化合物保留时间变化最小化。 第二取代基通过引入一个或多个芳族，多芳族，杂环芳族或多杂环芳族烃基来色谱和选择性地保留化合物，每个基团任选被脂族基团取代。
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Patent Agency Ranking
公开(公告)号：WO2013173501A8
公开(公告)日：2014-10-09
申请号：PCT/US2013041221
申请日：2013-05-15
Applicant: WATERS TECHNOLOGIES CORP
Inventor： WYNDHAM KEVIN D , MORRIS MICHAEL F , BROUSMICHE DARRYL W , HILL JASON F , FAIRCHILD JACOB N
CPC classification number: B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/32 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3234 , B01J20/3246 , B01J20/3285 , B01J20/3293 , B01J2220/54 , B01J2220/80 , C07F7/1836
Abstract: In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1:[X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05 ≤ (b/c) ≤ 100, and a ≥ 0.
Abstract translation: 一方面，本发明提供了用于由式1表示的各种不同色谱方式的色谱固定相材料：[X]（W）a（Q）b（T）c（式1）。 X可以是具有包含二氧化硅芯材料，金属氧化物芯材料，无机 - 有机杂化材料或其一组嵌段共聚物的表面的高纯度色谱芯组合物。 W可以不存在和/或可以包括氢和/或可以在X的表面上包括羟基.Q可以是在使用低水浓度的色谱条件下最小化随时间（漂移）的保留变化的官能团。 T可以包括与分析物色谱相互作用的一个或多个亲水性，极性的，可离子化的和/或带电的官能团。 另外，b和c可以是正数，其比例为0.05≤（b / c）≤100，a≥0。
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公开(公告)号：DE112013002519T5
公开(公告)日：2015-01-29
申请号：DE112013002519
申请日：2013-05-15
Applicant: WATERS TECHNOLOGIES CORP
Inventor： BROUSMICHE DARRYL W , WYNDHAM KEVIN D , FAIRCHILD JACOB N , IRANETA PAMELA C , HILL JASON F
Abstract: Die vorliegende Erfindung stellt ein chromatographisches Material der stationären Phase für verschiedene Chromatographiearten bereit. Ein Beispiel einer chromatographischen stationären Phase wird durch die Formel 1 [X](W)a(Q)b(T)c (Formel 1) dargestellt. X kann eine chromatographische Kernzusammensetzung von hoher Reinheit sein. W kann fehlen und/oder Wasserstoff bzw. Hydroxyl auf der Oberfläche von X enthalten. Q kann direkt an X gebunden sein und eine erste hydrophile, polare, ionisierbare und/oder geladene funktionelle Gruppe enthalten, die chromatographisch mit dem Analyten interagiert. T kann direkt an X gebunden sein und kann eine zweite hydrophile, polare, ionisierbare und/oder geladene funktionelle Gruppe enthalten, die chromatographisch mit dem Analyten interagiert. Daneben können Q und T im Wesentlichen chromatographische Wechselwirkungen zwischen dem Analyten und X sowie W aufheben, wodurch Retentionsabweichungen im Zeitablauf (Drift oder Veränderung) unter chromatographischen Bedingungen durch die Verwendung von niedrigen Wasserkonzentrationen minimiert werden.
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公开(公告)号：GB2515984A
公开(公告)日：2015-01-07
申请号：GB201420328
申请日：2013-05-15
Applicant: WATERS TECHNOLOGIES CORP
Inventor： BROUSMICHE DARRYL W , WYNDHAM KEVIN D , FAIRCHILD JACOB N , IRANETA PAMELA C , HILL JASON F
Abstract: The present invention provides a chromatographic stationary phase material various different types of chromatography. One example chromatographic stationary phase is represented by Formula 1 [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition. W can be absent and/or can include hydrogen and/or can include hydroxyl on the surface of X. Q can be bound directly to X and can include a first hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte. T can be bound directly to X and can include a second hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte. Additionally, Q and T can essentially eliminate chromatographic interaction between the analyte, and X and W, thereby minimizing retention variation over time (drift or change) under chromatographic conditions utilizing low water concentrations.
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公开(公告)号：DK3748340T3
公开(公告)日：2022-04-19
申请号：DK20188814
申请日：2015-10-28
Applicant: WATERS TECHNOLOGIES CORP
Inventor： LAUBER MATTHEW A , BROUSMICHE DARRYL W , KOZA STEPHAN M
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公开(公告)号：DK3213056T3
公开(公告)日：2020-09-28
申请号：DK15855907
申请日：2015-10-28
Applicant: WATERS TECHNOLOGIES CORP
Inventor： LAUBER MATTHEW A , BROUSMICHE DARRYL W , KOZA STEPHAN M
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