公开(公告)号：WO2022058856A1

公开(公告)日：2022-03-24

申请号：PCT/IB2021/058257

申请日：2021-09-10

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： PATEL, Amit ,  JUNG, Moon Chul ,  LAUBER, Matthew A. ,  WYNDHAM, Kevin ,  DELANO, Mathew ,  SIMEONE, Jennifer

IPC: G01N30/86 ,  G01N30/04 ,  G01N30/62 ,  G01N30/88 ,  B01D15/22 ,  B01D15/32 ,  B01D15/36

Abstract: The present disclosure is directed to methods of characterizing a system containing a chromatographic column. The methods can include introducing a sample comprising a positive control and a negative control to the system containing a chromatographic column, wherein the positive control is a sensitive probe that interacts with the system and the negative control is substantially non-interacting with the system; after passing the sample through the chromatographic column, detecting the positive control and the negative control; and determining system suitability by comparing the amount of detected positive control to negative control. In some embodiments, determining system suitability (e.g., inertness of sample to the system) is accomplished by determining a ratio of detected positive control to negative control.

公开(公告)号：WO2022058858A1

公开(公告)日：2022-03-24

申请号：PCT/IB2021/058260

申请日：2021-09-10

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： PATEL, Amit ,  LAUBER, Matthew A. ,  WYNDHAM, Kevin ,  DELANO, Mathew ,  SIMEONE, Jennifer

IPC: B05D1/00 ,  G01N30/52 ,  G01N30/56 ,  C07F7/08

Abstract: The present disclosure is directed to a kit for evaluating system inertness. The kit includes a positive control comprising a metal interacting moiety, and a negative control that does not contain a metal interacting moiety. In some embodiments the kit also includes a container to hold a system suitability solution (e.g., an equimolar mixture of the positive control and the negative control).

公开(公告)号：WO2022058857A1

公开(公告)日：2022-03-24

申请号：PCT/IB2021/058258

申请日：2021-09-10

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： PATEL, Amit ,  JUNG, Moon Chul ,  WALTER, Thomas H. ,  LAUBER, Matthew A. ,  WYNDHAM, Kevin ,  DELANO, Mathew ,  SIMEONE, Jennifer

IPC: B01D15/32 ,  B01D15/36 ,  C07F7/08 ,  G01N30/56 ,  G01N30/88

Abstract: The present disclosure is directed to methods for evaluating system inertness, such as the inertness of a LC or other fluidic system. Some methods are directed to tests wherein the column has been removed prior to injecting a sample including a positive (e.g., metal reacting moiety) control into the system. Some methods can include: (1) repeatedly injecting the sample into a system, the system comprising: fluidic paths wherein interior surfaces of the fluidic paths define wetted surfaces, and wherein at least a portion of the wetted surfaces of the fluidic flow path are coated with an inert coating, wherein the inert coating is inert to at least one analyte in the sample; (2) detecting a value associated with the positive control; and (3) analyzing values associated with the detected positive control to determine system inertness.

公开(公告)号：WO2021224834A1

公开(公告)日：2021-11-11

申请号：PCT/IB2021/053818

申请日：2021-05-05

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： LAUBER, Matthew A. ,  JUNG, Moon Chul ,  WALTER, Thomas ,  WYNDHAM, Kevin ,  CALTON, Lisa Jane ,  PATEL, Amit ,  DAVEY, Leanne ,  MORRISSEY, David ,  FOLEY, Dominic ,  ALDEN, Bonnie

IPC: G01N30/88 ,  G01N30/60 ,  G01N30/72 ,  G01N30/74 ,  G01N30/34

Abstract: The present disclosure relates to the use of vapor deposition coated flow paths for improved chromatography and sample analysis using liquid chromatography – mass spectrometry (LC/MS) or liquid chromatography –optical detection (LC/UV). More specifically, this technology relates to separating and quantitation of analytes (e.g., phospho prodrugs and its phosphorylated metabolites) from a sample matrix (e.g., mammalian blood, plasma) using chromatographic devices and fluidic systems having coated flow paths. The LC-MS or LC-UV techniques provide improved recovery, peak shape and dynamic range in the analysis of the prodrug and its metabolites.

公开(公告)号：EP4214501A1

公开(公告)日：2023-07-26

申请号：EP21770313.1

申请日：2021-09-10

Applicant: Waters Technologies Corporation

Inventor： PATEL, Amit ,  JUNG, Moon Chul ,  LAUBER, Matthew A. ,  WYNDHAM, Kevin ,  DELANO, Mathew ,  SIMEONE, Jennifer

IPC: G01N30/86 ,  G01N30/04 ,  G01N30/62 ,  G01N30/88 ,  B01D15/22 ,  B01D15/32 ,  B01D15/36

公开(公告)号：EP4213999A1

公开(公告)日：2023-07-26

申请号：EP21785982.6

申请日：2021-09-10

Applicant: Waters Technologies Corporation

Inventor： PATEL, Amit ,  LAUBER, Matthew A. ,  WYNDHAM, Kevin ,  DELANO, Mathew ,  SIMEONE, Jennifer

IPC: B05D1/00 ,  G01N30/52 ,  G01N30/56 ,  C07F7/08

公开(公告)号：EP4213959A1

公开(公告)日：2023-07-26

申请号：EP21772836.9

申请日：2021-09-10

Applicant: Waters Technologies Corporation

Inventor： PATEL, Amit ,  JUNG, Moon Chul ,  WALTER, Thomas H. ,  LAUBER, Matthew A. ,  WYNDHAM, Kevin ,  DELANO, Mathew ,  SIMEONE, Jennifer

IPC: B01D15/32 ,  B01D15/36 ,  C07F7/08 ,  G01N30/56 ,  G01N30/88

公开(公告)号：EP4147041A1

公开(公告)日：2023-03-15

申请号：EP21724792.3

申请日：2021-05-05

Applicant: Waters Technologies Corporation

Inventor： LAUBER, Matthew A. ,  JUNG, Moon Chul ,  WALTER, Thomas ,  WYNDHAM, Kevin ,  CALTON, Lisa Jane ,  PATEL, Amit ,  DAVEY, Leanne ,  MORRISSEY, David ,  FOLEY, Dominic ,  ALDEN, Bonnie

IPC: G01N30/88 ,  G01N30/60 ,  G01N30/72 ,  G01N30/74 ,  G01N30/34