-
公开(公告)号：WO2022079645A1
公开(公告)日：2022-04-21
申请号：PCT/IB2021/059426
申请日：2021-10-13
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： MCDONALD, Thomas S. , WYNDHAM, Kevin , VISSERS, Johannes
IPC: G01N33/569 , G01N33/68
Abstract: The present disclosure relates to methods and workflows for processing and analyzing clinical samples (e.g., nasal swabs, throat swabs, plasma samples, urine, etc.) In general, the methods and workflows involve the detection of an infectious state and are improved over contemporary methods due to increased throughput with improved resolution of positive results.
-
公开(公告)号：WO2023089538A1
公开(公告)日：2023-05-25
申请号：PCT/IB2022/061109
申请日：2022-11-17
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： TUNC SARISOZEN, Yeliz , LAWRENCE, Nicole L. , BROUSMICHE, Darryl W. , XU, Mingcheng , WYNDHAM, Kevin
IPC: B01J20/10 , B01J20/28 , B01J20/288 , B01J20/32
Abstract: The present disclosure is directed to surface modified materials such as stationary phase materials for performing size exclusion chromatography. Aspects of the present disclosure feature materials surface modified with a moiety including a polyethylene glycol (PEG) functionality and a moiety comprising a diol functionality, each of those moieties at a coverage density of at least 0.05 μmol/m2. Such surface modified materials exhibit a reduced propensity for ionic and hydrophobic secondary interactions.
-
公开(公告)号：WO2018134662A1
公开(公告)日：2018-07-26
申请号：PCT/IB2017/058166
申请日：2017-12-19
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： LEVEILLE, Wade P. , BELANGER, Jonathan L. , JUNG, Moon Chul , TARAFDER, Abhijit , MICHIENZI, Joseph , FADGEN, Keith , WYNDHAM, Kevin , SONG, Xiangjin
IPC: G01N30/32
Abstract: The present disclosure relates to methods and devices for providing pressurized solvent flow in chromatography systems. In one embodiment at least one divert valve is in fluid communication with at least one solvent source (Container); and a pump (LC Pump) is in fluid communication with the at least one divert valve, wherein the at least one divert valve is located in between the at least one solvent source and the pump, and wherein the at least one divert valve is adapted for diverting at least one solvent flow stream to the pump or to an auxiliary flow path.
-
公开(公告)号：WO2023026251A1
公开(公告)日：2023-03-02
申请号：PCT/IB2022/058018
申请日：2022-08-26
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： XU, MingCheng , BROUSMICHE, Darryl W. , WYNDHAM, Kevin , WALSH, Daniel P. , LAWRENCE, Nicole L.
IPC: B01J20/28
Abstract: In various embodiments, the present disclosure pertains to organic polymer core-shell particles that comprise a non-porous organic polymer core (i.e., having a pore volume of less than 0.1 cc/g) and a porous organic polymer shell (i.e., having a pore volume of greater than 0.1 cc/g), in which the porous organic polymer shell has a pore size ranging from 100 Å to 3000 Å. In some embodiments, the present disclosure pertains to chromatographic separation devices that comprise such organic polymer core-shell particles. In some embodiments, the present disclosure pertains to chromatographic methods that comprise: (a) loading a sample onto a chromatographic column comprising such organic polymer core-shell particles and (b) flowing a mobile phase through the column.
-
公开(公告)号：WO2022064447A1
公开(公告)日：2022-03-31
申请号：PCT/IB2021/058741
申请日：2021-09-24
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： DELANO, Mathew , LAUBER, Matthew A. , WYNDHAM, Kevin , NGUYEN, Jennifer M.
IPC: G01N30/60
Abstract: The present disclosure relates to a method of reducing degradation of sample components in a liquid chromatography system. The method utilizes a masked metal frit to prevent or reduce metal surfaces from becoming catalytically active. The masked metal frit is a metal based frit that includes a coating on its exterior surfaces to mask or prevent contact between the organic solvents (and/or any analyte or other related solvent) and the underlying metal. The coating is a vapor deposited inorganic-organic hybrid coating, such as a vapor deposited C2 coating.
-
Patent Agency Ranking
公开(公告)号：WO2019239329A1
公开(公告)日：2019-12-19
申请号：PCT/IB2019/054880
申请日：2019-06-11
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： WYNDHAM, Kevin , LAUBER, Matthew A.
Abstract: The present invention is directed to a method for performing size exclusion chromatography. Embodiments of the present invention feature devices and methods for improving the speed and separations of size exclusion chromatography using a stationary phase material comprising small particles (
-
公开(公告)号：WO2023067487A1
公开(公告)日：2023-04-27
申请号：PCT/IB2022/059978
申请日：2022-10-18
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： LAUBER, Matthew A. , WYNDHAM, Kevin , FEKETE, Szabolcs , YANG, Hua , KOZA, Stephan
Abstract: The present invention relates to a method for separating a sample comprising a nucleic acid, the method comprising: (a) loading a sample comprising a nucleic acid onto an anion-exchange column; and (b) eluting the sample from the anion-exchange column using a salt gradient, wherein a mobile phase used in the eluting step comprises a mild ion-pairing cation, and wherein a column temperature of the anion-exchange column is greater than 30°C. The present invention also relates to a method for determining one or more calorimetric properties of a nucleic acid using anion-exchange chromatography.
-
公开(公告)号：WO2023026258A1
公开(公告)日：2023-03-02
申请号：PCT/IB2022/058031
申请日：2022-08-26
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： XU, MingCheng , BROUSMICHE, Darryl W. , WALSH, Daniel P. , LAWRENCE, Nicole L. , WYNDHAM, Kevin
IPC: B01J20/28
Abstract: In various embodiments, the present disclosure pertains to core-shell particles that comprise a porous hybrid organic-inorganic shell disposed on a surface-modified non-porous polymer particle core. In some embodiments, the present disclosure pertains to chromatographic separation devices that comprise such core-shell particles. In some embodiments, the present disclosure pertains to chromatographic methods that comprise: (a) loading a sample onto a chromatographic column comprising such core-shell particles and (b) flowing a mobile phase through the column.
-
9.发明申请
公开(公告)号：WO2022058856A1
公开(公告)日：2022-03-24
申请号：PCT/IB2021/058257
申请日：2021-09-10
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： PATEL, Amit , JUNG, Moon Chul , LAUBER, Matthew A. , WYNDHAM, Kevin , DELANO, Mathew , SIMEONE, Jennifer
Abstract: The present disclosure is directed to methods of characterizing a system containing a chromatographic column. The methods can include introducing a sample comprising a positive control and a negative control to the system containing a chromatographic column, wherein the positive control is a sensitive probe that interacts with the system and the negative control is substantially non-interacting with the system; after passing the sample through the chromatographic column, detecting the positive control and the negative control; and determining system suitability by comparing the amount of detected positive control to negative control. In some embodiments, determining system suitability (e.g., inertness of sample to the system) is accomplished by determining a ratio of detected positive control to negative control.
-
公开(公告)号：WO2022058858A1
公开(公告)日：2022-03-24
申请号：PCT/IB2021/058260
申请日：2021-09-10
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： PATEL, Amit , LAUBER, Matthew A. , WYNDHAM, Kevin , DELANO, Mathew , SIMEONE, Jennifer
Abstract: The present disclosure is directed to a kit for evaluating system inertness. The kit includes a positive control comprising a metal interacting moiety, and a negative control that does not contain a metal interacting moiety. In some embodiments the kit also includes a container to hold a system suitability solution (e.g., an equimolar mixture of the positive control and the negative control).
-
-
-
-
-
-
-
-
-
Search Results
26
records
(took 0.028 seconds)
