THERMALLY-CONTROLLED LOW PRESSURE MIXING SYSTEM FOR LIQUID CHROMATOGRAPHY

    公开(公告)号:WO2022169710A1

    公开(公告)日:2022-08-11

    申请号:PCT/US2022/014555

    申请日:2022-01-31

    Abstract: Described is a solvent manager for a liquid chromatography system. The solvent manager includes a temperature control module, a plurality of solvent reservoirs, a gradient proportioning valve and a degasser. The temperature control module maintains a substantially constant temperature of one or more of the plurality of solvent reservoirs, gradient proportioning valve and degasser. The temperature control module may include a thermal chamber having an enclosure with a thermally controlled internal environment and may also include an active thermal element such as one or more heaters. The enclosure may surround at least one of the plurality of solvent reservoirs, gradient proportioning valve and degasser. The temperature control module reduces the negative effects on solvent composition that result from temperature-dependent changes in solvent viscosities and solvent densities. Such changes affect the retention times of analytes eluted from the chromatographic column.

    GRADIENT PROPORTIONING VALVE
    4.
    发明公开

    公开(公告)号:EP4517089A2

    公开(公告)日:2025-03-05

    申请号:EP24212225.7

    申请日:2020-11-25

    Abstract: Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, an actuation mechanism having a piston located within a bored structure surrounding the piston, the actuation mechanism configured to open and close at least one of the plurality of conduits in a controlled manner where the piston and the bored structure have a tight tolerance configured to create a fluid tight seal, and a common outlet port configured to receive the fluid composition.

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