-
1.发明公开Modulators of the function of FAS receptors and other proteins 失效Modulatoren der FAS-Rezeptor-Funktion und die Funktion anderer Proteine
公开(公告)号：EP2042509A1
公开(公告)日：2009-04-01
申请号：EP08018971.5
申请日：1996-06-14
Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.
Inventor： Wallach, David , Boldin, Mark , Goncharov, Tanya , Goltsev, Yury
CPC classification number: C12N9/641 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K14/715 , C07K14/7151 , C07K16/2866 , C07K2319/00 , C12N9/6475
Abstract: The present invention provides proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD which binds to the p55 receptor. In addition, peptide inhibitors which interfere with the proteolytic activity of MORT-1-binding proteins having proteolytic activity are provided as well as a method of designing them.
Abstract translation: 本发明提供能够通过与MORT-1蛋白结合或相互作用而与携带FAS受体或p55受体的细胞调节或介导FAS受体配体或TNF作用的蛋白，其又结合FAS受体的细胞内结构域或另一种结合 结合p55受体的蛋白质TRADD。 此外，提供干扰具有蛋白水解活性的MORT-1结合蛋白的蛋白水解活性的肽抑制剂以及其设计方法。
-
公开(公告)号：EP0512528B1
公开(公告)日：1999-09-15
申请号：EP92107685.7
申请日：1992-05-07
Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.
Inventor： Wallach, David , Aderka, Dan , Engelmann, Hartmut
IPC: A61K38/00
CPC classification number: A61K38/1793
-
公开(公告)号：EP0512528A2
公开(公告)日：1992-11-11
申请号：EP92107685.7
申请日：1992-05-07
Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.
Inventor： Wallach, David , Aderka, Dan , Engelmann, Hartmut
IPC: A61K37/02
CPC classification number: A61K38/1793
Abstract: Tumor Necrosis Factor Binding Proteins (TBPs) are useful in the treatment of autoimmune diseases and graft-versus-host reactions.
Abstract translation: 肿瘤坏死因子结合蛋白（TBPs）可用于治疗自身免疫性疾病和移植物抗宿主反应。
-
公开(公告)号：EP0412486B1
公开(公告)日：1994-11-30
申请号：EP90115105.0
申请日：1990-08-06
Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.
Inventor： Wallach, David , Engelmann, Harmut , Aderka, Dan
IPC: C12P21/08 , A61K39/395 , G01N33/577 , G01N33/68 , C07K3/18
CPC classification number: C07K16/2866 , A61K38/00 , C07K14/7151
-
公开(公告)号：EP0512528A3
公开(公告)日：1993-07-21
申请号：EP92107685.7
申请日：1992-05-07
Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.
Inventor： Wallach, David , Aderka, Dan , Engelmann, Hartmut
IPC: A61K37/02
CPC classification number: A61K38/1793
Abstract: Tumor Necrosis Factor Binding Proteins (TBPs) are useful in the treatment of autoimmune diseases and graft-versus-host reactions.
-
Patent Agency Ranking6.发明授权Process for the determination of interferon and kit for the assay of interferon 失效用于确定干扰物和干燥剂测定工具的方法
公开(公告)号：EP0105221B1
公开(公告)日：1987-03-25
申请号：EP83108837.2
申请日：1983-09-07
Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.
Inventor： Revel, Michel , Wallach, David
IPC: G01N33/68 , G01N33/569
CPC classification number: C12Q1/70 , G01N33/56983 , G01N33/6866 , Y10S435/84 , Y10S435/975 , Y10S436/804 , Y10S436/808 , Y10S436/828
-
公开(公告)号：EP2042509B1
公开(公告)日：2013-02-20
申请号：EP08018971.5
申请日：1996-06-14
Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.
Inventor： Wallach, David , Boldin, Mark , Goncharov, Tanya , Goltsev, Yury
CPC classification number: C12N9/641 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K14/715 , C07K14/7151 , C07K16/2866 , C07K2319/00 , C12N9/6475
-
8.发明公开Promotor sequence of the p55 tumor necrosis factor receptor 失效启动子 - 消化系统p55 von Tumor-Nekrosis-Faktor。
公开(公告)号：EP0606869A1
公开(公告)日：1994-07-20
申请号：EP94100243.8
申请日：1994-01-10
Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.
Inventor： Wallach, David , Kemper, Oliver
IPC: C12N15/85 , A61K31/505 , C12Q1/68
CPC classification number: C12N15/1138 , C12N15/85 , C12N2310/13 , C12N2830/00 , C12N2830/85
Abstract: A promoter sequence of the human p55 TNF-R gene is provided. Also provided are sequence motifs and motif regions contained within the promoter sequence. Methods for preparing these motifs or motif regions and their use in the modulation of TNF function are also provided.
Abstract translation: 提供人p55 TNF-R基因的启动子序列。 还提供了包含在启动子序列内的序列基序和基序区域。 还提供了制备这些基序或基序区域的方法及其在调节TNF功能中的用途。
-
公开(公告)号：EP0606869B1
公开(公告)日：2003-04-09
申请号：EP94100243.8
申请日：1994-01-10
Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.
Inventor： Wallach, David , Kemper, Oliver
IPC: C12N15/85 , A61K31/7088 , C12Q1/68
CPC classification number: C12N15/1138 , C12N15/85 , C12N2310/13 , C12N2830/00 , C12N2830/85
-
10.发明公开Antibodies to TNF binding protein I and F (ab) fragments thereof 失效Antikörpergegen TNF-Bindungsprotein I und deren F（ab）-Fragmente。
公开(公告)号：EP0412486A1
公开(公告)日：1991-02-13
申请号：EP90115105.0
申请日：1990-08-06
Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.
Inventor： Wallach, David , Engelmann, Harmut , Aderka, Dan
IPC: C12P21/08 , A61K39/395 , G01N33/577 , G01N33/68 , C07K3/18
CPC classification number: C07K16/2866 , A61K38/00 , C07K14/7151
Abstract: Antibodies to TNF Binding Protein I (TBP-I) and F(ab) fragments thereof are provided that can be used in diagnostic assays and pharmaceutical agents for either inhibiting or mimicking the effects of TNF on cells.
Abstract translation: 提供了针对TNF结合蛋白I（TBP-1）和F（ab）片段的抗体，其可用于诊断测定和用于抑制或模拟TNF对细胞的作用的药物。
-
-
-
-
-
-
-
-
-
Search Results
11
records
(took 0.034 seconds)
