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Patent Agency Ranking1.发明授权Human gamma interferon-specific receptor protein, antibody against said protein, methods for obtaining said protein and said antibody and compositions containing said protein and antibody 失效人γ特异性干扰素受体蛋白质，针对该蛋白质的抗体，所述用于产生该蛋白的方法和抗体和所述蛋白和所述含有抗体的组合物。
公开(公告)号：EP0240975B1
公开(公告)日：1994-08-10
申请号：EP87105078.7
申请日：1987-04-06
Inventor： Novick, Daniela , Orchansky, Patricia , Fischer, Dina , Rubinstein, Menachem
IPC: C07K15/06 , C07K3/28 , A61K37/66 , A61K39/395 , A61K37/02
CPC classification number: C07K16/2866 , A61K38/00 , A61K39/395 , C07K14/715 , A61K2300/00
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2.发明授权
公开(公告)号：EP0117470B1
公开(公告)日：1987-09-09
申请号：EP84101404.6
申请日：1984-02-10
Inventor： Rubinstein, Menachem , Friedlander, Jossef , Fischer, Dina
CPC classification number: C07K14/57 , A61K38/00 , B01D15/362 , B01D61/145 , B01D61/18 , B01D2313/40
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3.发明公开Process for producing interferon (IFN-gamma) subtypes 26K and 21K 失效Verfahren zur Herstellung von Interferon（IFN-gamma）des Typs 26K und 21K。
公开(公告)号：EP0117470A1
公开(公告)日：1984-09-05
申请号：EP84101404.6
申请日：1984-02-10
Inventor： Rubinstein, Menachem , Friedlander, Jossef , Fischer, Dina
CPC classification number: C07K14/57 , A61K38/00 , B01D15/362 , B01D61/145 , B01D61/18 , B01D2313/40
Abstract: Described is a process for the purification of human immune interferon (IFN-y) to homogeneity without appreciable loss of biological activity by the use of chromatography on controlled-pore glass, ultrafiltration and high performance cation exchange chromatography, resulting in essentially pure human interferon subtypes 21 K and 26K. Furthermore, there are described pharmaceutical compositions containing said purified interferons.
Abstract translation: 描述了通过在受控孔玻璃上的色谱法，超滤和高性能阳离子交换色谱法将人免疫干扰素（IFN-γ）纯化成均匀性而没有明显的生物活性损失的方法，导致基本上纯的人干扰素亚型 21K和26K。 此外，描述了含有所述纯化的干扰素的药物组合物。
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4.发明公开Human gamma interferon-specific receptor protein, antibody against said protein, methods for obtaining said protein and said antibody and compositions containing said protein and antibody 失效人类干扰素特异性受体蛋白质，抗体蛋白质抗体，获得蛋白质和抗体的方法以及含有蛋白质和抗体的组合物
公开(公告)号：EP0240975A3
公开(公告)日：1989-09-13
申请号：EP87105078.7
申请日：1987-04-06
Inventor： Novick, Daniela , Orchansky, Patricia , Fischer, Dina , Rubinstein, Menachem
IPC: C07K15/06 , C07K3/28 , A61K37/66 , A61K39/395 , A61K37/02
CPC classification number: C07K16/2866 , A61K38/00 , A61K39/395 , C07K14/715 , A61K2300/00
Abstract: Analysis of[¹²⁵I]. interferon gamma cross-linked to its receptor on various human cells by SDS-PAGE revealed that there are at least three different types of human interferon gamma receptors. In WISH, HeLa, FS11 and other tissue cells an Mr 90,000-105,000 receptor was found. In monocytes and in the myeloid cell line KG-1 an Mr 140,000 receptor was found while in Daudi lymphoblastoid cells an Mr 95,000-115,000 receptor was found. The various receptors were isolated from these cells by extraction followed by affinity chromotography on an immobilized interferon gamma column. The resulting purified preparations retained their original affinity for interferon gamma and were used for immunizing mice and subsequent development of highly specific antibodies.
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5.发明公开Human gamma interferon-specific receptor protein, antibody against said protein, methods for obtaining said protein and said antibody and compositions containing said protein and antibody 失效人γ特异性干扰素受体蛋白质，针对该蛋白质的抗体，所述用于产生该蛋白的方法和抗体和所述蛋白和所述含有抗体的组合物。
公开(公告)号：EP0240975A2
公开(公告)日：1987-10-14
申请号：EP87105078.7
申请日：1987-04-06
Inventor： Novick, Daniela , Orchansky, Patricia , Fischer, Dina , Rubinstein, Menachem
IPC: C07K15/06 , C07K3/28 , A61K37/66 , A61K39/395 , A61K37/02
CPC classification number: C07K16/2866 , A61K38/00 , A61K39/395 , C07K14/715 , A61K2300/00
Abstract: Analysis of[¹²⁵I]. interferon gamma cross-linked to its receptor on various human cells by SDS-PAGE revealed that there are at least three different types of human interferon gamma receptors. In WISH, HeLa, FS11 and other tissue cells an Mr 90,000-105,000 receptor was found. In monocytes and in the myeloid cell line KG-1 an Mr 140,000 receptor was found while in Daudi lymphoblastoid cells an Mr 95,000-115,000 receptor was found.
The various receptors were isolated from these cells by extraction followed by affinity chromotography on an immobilized interferon gamma column. The resulting purified preparations retained their original affinity for interferon gamma and were used for immunizing mice and subsequent development of highly specific antibodies.Abstract translation: 分析[<1> <2> <5> I]的。 干扰素γ交联到其上的各种人细胞的受体，通过SDS-PAGE揭示thatthere至少三种不同类型的人类干扰素γ受体。 在WISH，HeLa细胞，FS11和其他组织细胞先生90.000到105.000受体其中发现。 在单核细胞和在骨髓细胞系KG-1到140000先生受体其中发现，而在将Daudi类淋巴母细胞给Mr 95.000到115.000受体其中发现。 各种受体的细胞从通过萃取论文其次上固定化干扰素γ柱层析亲和力分离。 将所得的纯化制剂保留其原有亲和性的干扰素γ，并用于免疫小鼠和高度特异性的抗体的后续发展。
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