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1.发明授权
公开(公告)号：EP0117470B1
公开(公告)日：1987-09-09
申请号：EP84101404.6
申请日：1984-02-10
Inventor： Rubinstein, Menachem , Friedlander, Jossef , Fischer, Dina
CPC classification number: C07K14/57 , A61K38/00 , B01D15/362 , B01D61/145 , B01D61/18 , B01D2313/40
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2.发明公开Process for producing interferon (IFN-gamma) subtypes 26K and 21K 失效Verfahren zur Herstellung von Interferon（IFN-gamma）des Typs 26K und 21K。
公开(公告)号：EP0117470A1
公开(公告)日：1984-09-05
申请号：EP84101404.6
申请日：1984-02-10
Inventor： Rubinstein, Menachem , Friedlander, Jossef , Fischer, Dina
CPC classification number: C07K14/57 , A61K38/00 , B01D15/362 , B01D61/145 , B01D61/18 , B01D2313/40
Abstract: Described is a process for the purification of human immune interferon (IFN-y) to homogeneity without appreciable loss of biological activity by the use of chromatography on controlled-pore glass, ultrafiltration and high performance cation exchange chromatography, resulting in essentially pure human interferon subtypes 21 K and 26K. Furthermore, there are described pharmaceutical compositions containing said purified interferons.
Abstract translation: 描述了通过在受控孔玻璃上的色谱法，超滤和高性能阳离子交换色谱法将人免疫干扰素（IFN-γ）纯化成均匀性而没有明显的生物活性损失的方法，导致基本上纯的人干扰素亚型 21K和26K。 此外，描述了含有所述纯化的干扰素的药物组合物。
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