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1.发明公开Antiviral pharmaceutical compositions containing hypericin or pseudohypericin 失效含有高胆固醇或精氨酸的抗病毒药物组合物
公开(公告)号：EP0256452A3
公开(公告)日：1990-01-17
申请号：EP87111467.4
申请日：1987-08-07
Inventor： Lavie, David , Revel, Michel , Rotman, Dalia , Vande Velde, Vincent
IPC: A61K31/12
CPC classification number: A61K31/12
Abstract: Described is the use of hypericin or pseudohypericin as active therapeutic substances in the treatment of, and alleviation of symptoms of various diseases caused by viruses such as vesicular stomatitis, influenza, herpes simplex, HSV-1 and HSV-2. The mode of activity seems to be by inhibition of RNA synthesis and interfering with virus replication. Pharmaceutical compositions can be applied by a variety of routes. Topical applications have proved to be effective against a variety of viral afflictions.
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Patent Agency Ranking2.发明授权Antiviral pharmaceutical compositions containing hypericin or pseudohypericin 失效含金丝桃素和伪金丝桃素的抗病毒的药物组合物。
公开(公告)号：EP0256452B1
公开(公告)日：1993-11-03
申请号：EP87111467.4
申请日：1987-08-07
Inventor： Lavie, David , Revel, Michel , Rotman, Dalia , Vande Velde, Vincent
IPC: A61K31/12
CPC classification number: A61K31/12
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公开(公告)号：EP0432496A2
公开(公告)日：1991-06-19
申请号：EP90121796.8
申请日：1990-11-14
Inventor： Mazur, Yehuda , Bock, Harald , Lavie, David
IPC: C07C50/36 , A61K31/125
Abstract: A process for preparing hypericin comprises oxidative dimerization of emodin anthrone and conversion of the intermediate protohypericin to hypericin by irradiation with visible light.
Abstract translation: 制备金丝桃素的方法包括大黄素蒽酮的氧化二聚作用，并通过用可见光照射将中间体原肌松素转化为金丝桃素。
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公开(公告)号：EP0432496B1
公开(公告)日：1995-02-01
申请号：EP90121796.8
申请日：1990-11-14
Inventor： Mazur, Yehuda , Bock, Harald , Lavie, David
IPC: C07C50/36 , A61K31/125
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公开(公告)号：EP0432496A3
公开(公告)日：1991-10-23
申请号：EP90121796.8
申请日：1990-11-14
Inventor： Mazur, Yehuda , Bock, Harald , Lavie, David
IPC: C07C50/36 , A61K31/125
Abstract: A process for preparing hypericin comprises oxidative dimerization of emodin anthrone and conversion of the intermediate protohypericin to hypericin by irradiation with visible light.
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6.发明公开Antiviral pharmaceutical compositions containing hypericin or pseudohypericin 失效Antivirale pharmazeutische Zusammensetzungen enthaltende Hypericine oder Pseudohypericine。
公开(公告)号：EP0256452A2
公开(公告)日：1988-02-24
申请号：EP87111467.4
申请日：1987-08-07
Inventor： Lavie, David , Revel, Michel , Rotman, Dalia , Vande Velde, Vincent
IPC: A61K31/12
CPC classification number: A61K31/12
Abstract: Described is the use of hypericin or pseudohypericin as active therapeutic substances in the treatment of, and alleviation of symptoms of various diseases caused by viruses such as vesicular stomatitis, influenza, herpes simplex, HSV-1 and HSV-2. The mode of activity seems to be by inhibition of RNA synthesis and interfering with virus replication. Pharmaceutical compositions can be applied by a variety of routes. Topical applications have proved to be effective against a variety of viral afflictions.
Abstract translation: 描述了金丝桃素或假倍他辛霉素作为活性治疗物质在治疗和缓解由诸如水泡性口炎，流感，单纯疱疹，HSV-1和HSV-2等病毒引起的各种疾病的症状的用途。 活动模式似乎是通过抑制RNA合成和干扰病毒复制。 药物组合物可以通过各种途径施用。 已证明局部应用对各种病毒性疾病有效。
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