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公开(公告)号：EP0369413A2
公开(公告)日：1990-05-23
申请号：EP89121094.0
申请日：1989-11-14
Inventor： Novick, Daniela , Mory, Yves , Fischer, Dina G. , Revel, Michel , Rubinstein, Menachem
IPC: C12N15/12 , A61K38/17 , C07K14/715 , C12N5/10 , C12N1/11 , C12P21/08 , A61K39/395 , C12N5/20
CPC classification number: C07K14/7156 , A61K38/00 , C07K14/715 , C07K16/2866
Abstract: A DNA molecule comprising a recombinant DNA molecule or a cDNA molecule comprising the following nucleotide sequence, a protein wherein at least part of the protein molecule is encoded by the following nucleotide sequence or a pharmaceutical composition comprising said protein. The protein is used for protecting against the deteterious effects of IFN-gamma in mammals.
Abstract translation: 包含重组DNA分子或包含以下核苷酸序列的cDNA分子的DNA分子，其中至少部分蛋白质分子由以下核苷酸序列编码的蛋白质或包含所述蛋白质的药物组合物。 该蛋白质用于防止哺乳动物中IFN-γ的有害作用。
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2.发明公开Antiviral pharmaceutical compositions containing hypericin or pseudohypericin 失效含有高胆固醇或精氨酸的抗病毒药物组合物
公开(公告)号：EP0256452A3
公开(公告)日：1990-01-17
申请号：EP87111467.4
申请日：1987-08-07
Inventor： Lavie, David , Revel, Michel , Rotman, Dalia , Vande Velde, Vincent
IPC: A61K31/12
CPC classification number: A61K31/12
Abstract: Described is the use of hypericin or pseudohypericin as active therapeutic substances in the treatment of, and alleviation of symptoms of various diseases caused by viruses such as vesicular stomatitis, influenza, herpes simplex, HSV-1 and HSV-2. The mode of activity seems to be by inhibition of RNA synthesis and interfering with virus replication. Pharmaceutical compositions can be applied by a variety of routes. Topical applications have proved to be effective against a variety of viral afflictions.
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3.发明授权Soluble extracellular fragment of the human IFN-beta 2/IL-6 receptor, its preparation and pharmaceutical compositions containing it 失效Löslisches人类IFN金属-β2/ IL-6受体，其制备的细胞外片段和含有药物混合物该片段
公开(公告)号：EP0413908B2
公开(公告)日：2005-08-03
申请号：EP90110487.7
申请日：1990-06-01
Inventor： Novick, Daniela , Chen, Louis , Engelmann, Hartmut , Revel, Michel , Rubinstein, Menachem , Wallach, David
CPC classification number: C07K14/715 , A61K38/215 , C07K14/7155 , Y10S530/834 , A61K2300/00
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公开(公告)号：EP0369413B1
公开(公告)日：1995-10-04
申请号：EP89121094.0
申请日：1989-11-14
Inventor： Novick, Daniela , Mory, Yves , Fischer, Dina G. , Revel, Michel , Rubinstein, Menachem
IPC: C12N15/12 , A61K38/17 , C07K14/715 , C12N5/10 , C12N1/11 , C12P21/08 , A61K39/395 , C12N5/20
CPC classification number: C07K14/7156 , A61K38/00 , C07K14/715 , C07K16/2866
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公开(公告)号：EP0369413A3
公开(公告)日：1990-09-26
申请号：EP89121094.0
申请日：1989-11-14
Inventor： Novick, Daniela , Mory, Yves , Fischer, Dina G. , Revel, Michel , Rubinstein, Menachem
IPC: C12N15/12 , A61K38/17 , C07K14/715 , C12N5/10 , C12N1/11 , C12P21/08 , A61K39/395 , C12N5/20
CPC classification number: C07K14/7156 , A61K38/00 , C07K14/715 , C07K16/2866
Abstract: A DNA molecule comprising a recombinant DNA molecule or a cDNA molecule comprising the following nucleotide sequence, a protein wherein at least part of the protein molecule is encoded by the following nucleotide sequence or a pharmaceutical composition comprising said protein. The protein is used for protecting against the deteterious effects of IFN-gamma in mammals.
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Patent Agency Ranking6.发明授权Antiviral pharmaceutical compositions containing hypericin or pseudohypericin 失效含金丝桃素和伪金丝桃素的抗病毒的药物组合物。
公开(公告)号：EP0256452B1
公开(公告)日：1993-11-03
申请号：EP87111467.4
申请日：1987-08-07
Inventor： Lavie, David , Revel, Michel , Rotman, Dalia , Vande Velde, Vincent
IPC: A61K31/12
CPC classification number: A61K31/12
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7.发明授权Human interferon beta2A, vectors containing genes coding for said interferon, cell lines producing same 失效人干扰素beta2A; 含有编码用于所述干扰素基因的载体; 细胞系生产这种及使用所述干扰素作为药物
公开(公告)号：EP0220574B2
公开(公告)日：2000-04-12
申请号：EP86114049.9
申请日：1986-10-10
Inventor： Revel, Michel , Zilberstein, Asher
CPC classification number: C07K14/565 , A61K38/215 , C07K14/5412
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8.发明公开Soluble extracellular fragment of the human IFN-beta 2/IL-6 receptor, its preparation and pharmaceutical compositions containing it 失效IFN-β2 / IL-6受体，其制备方法和这些含有受体的药物混合物。
公开(公告)号：EP0413908A2
公开(公告)日：1991-02-27
申请号：EP90110487.7
申请日：1990-06-01
Inventor： Novick, Daniela , Chen, Louis , Engelmann, Hartmut , Revel, Michel , Rubinstein, Menachem , Wallach, David
CPC classification number: C07K14/715 , A61K38/215 , C07K14/7155 , Y10S530/834 , A61K2300/00
Abstract: Human natural IFN-β2/IL-6 receptor and its soluble extracellular fragment are provided in substantially purified form and are shown to stimulate and to enhance beneficial effects of IFN-β2/IL-6, such as its antiproliferative activity. Polyclonal and monoclonal antibodies raised against the soluble fragment of the receptor are also provided.
Abstract translation: 人天然IFN-β2/ IL-6受体和其可溶性细胞外片段以基本上纯化的形式提供，并且被示出，以刺激和增强IFN-β2/ IL-6，颜色的有益效果：例如它的抗增殖活性。 因此，提供针对该受体的可溶性片段产生的多克隆和单克隆抗体。
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公开(公告)号：EP0326120A3
公开(公告)日：1990-05-02
申请号：EP89101295.7
申请日：1989-01-25
Inventor： Revel, Michel , Rubinstein, Menachem , Mory, Yves , Chen, Louise , Novick, Daniela , Michalevicz, Rita
CPC classification number: C07K16/248 , A61K38/00 , C07K14/31 , C07K14/5412 , C07K2317/77 , C07K2319/705 , C07K2319/75
Abstract: Monoclonal antibodies to IFN-β2/IL-6 and hybridomas producing them and production and purification of glycosylated and unglycosylated IFN-β2/ IL-6 are disclosed. The protein is useful in the treatment of breast cancer, leukemia, infectious diseases and bone marrow progenitor cell disorders.
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公开(公告)号：EP0326120B1
公开(公告)日：1998-04-15
申请号：EP89101295.7
申请日：1989-01-25
Inventor： Revel, Michel , Rubinstein, Menachem , Mory, Yves , Chen, Louise , Novick, Daniela , Michalevicz, Rita
CPC classification number: C07K16/248 , A61K38/00 , C07K14/31 , C07K14/5412 , C07K2317/77 , C07K2319/705 , C07K2319/75
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