一种光纤共焦动态拉曼光谱探测装置及探测方法

    公开(公告)号:CN106290301A

    公开(公告)日:2017-01-04

    申请号:CN201610640617.9

    申请日:2016-08-08

    CPC classification number: G01N21/65 G01N2201/061 G01N2201/0893

    Abstract: 本发明涉及激光探测领域,特别涉及一种光纤共焦动态拉曼光谱探测装置及探测方法。本发明提供的光纤共焦动态拉曼光谱探测装置及方法采用脉冲激光代替传统拉曼探测装置中的连续激光作为产生拉曼信号的光源,将激光器和光谱收集装置的触发时间进行同步,通过调节这个触发时间和对被测物质进行激发的激发源的触发时间之间的延迟时间来实现时间分辨能力;同时,所述探测装置通过使用一个光纤跨接器件将与激光器连接的第一光纤、与被测物质端连接的第二光纤以及与光谱收集装置连接的第三光纤耦合在一起,连接完成了激光激发光路及拉曼信号收集光路。

    Method and apparatus for imaging a physical parameter in turbid media
using diffuse waves
    3.
    发明授权
    Method and apparatus for imaging a physical parameter in turbid media using diffuse waves 失效
    使用DIFFUSE波形在涡轮介质中成像物理参数的方法和装置

    公开(公告)号:US5203339A

    公开(公告)日:1993-04-20

    申请号:US722823

    申请日:1991-06-28

    Abstract: Imaging of a turbid object utilizes interference among the modulation wavefronts of a plurality of modulated light rays propagating through the object by diffusion and having predetermined phases relative to one another. A computer controlled phase and amplitude selecting device, such as a zone plate, is used to modulate light rays at appropriate phases in order to obtain constructive interference only at a predetermined portion of the object, including one or more preselected voxels. The rays reflected from (or diffusively transmitted through) the predetermined portion are received simultaneously at a detector, thus providing simultaneously all the data necessary to describe or image the portion. A single detector element may be used to detect the scattered reflected or transmitted light from the portion and to generate a signal representing the amplitude and phase characteristics for the modulation wavefront, thereby to provide absorption (and other) characteristics descriptive of the portion. An array of detectors may be used to detect the light from a plurality of individual voxels simultaneously and to provide such characteristics for each of the voxels. By dynamically controlling the phase and amplitude selecting device, the voxels selected for imaging are changed without mechanical scanning. Light rays having different frequencies may be modulated to provide complete absorption spectra for an arbitrarily selected portion of the object.

    Abstract translation: 浑浊物体的成像利用通过扩散传播通过物体的多个调制光线的调制波前的相互干扰,并相对于彼此具有预定的相位。 使用计算机控制的相位和幅度选择装置(例如区域板)在适当的相位调制光线,以便仅在物体的预定部分(包括一个或多个预选的体素)处获得建设性的干扰。 从(或扩散传输)预定部分反射的光线在检测器处同时接收,从而同时提供描述或成像该部分所需的所有数据。 可以使用单个检测器元件来检测来自该部分的散射的反射或透射的光并且产生表示调制波前的幅度和相位特性的信号,从而提供描述该部分的吸收(和其它)特性。 可以使用一组检测器来同时检测来自多个单独体素的光,并为每个体素提供这样的特征。 通过动态地控制相位和幅度选择装置,选择用于成像的体素没有机械扫描而改变。 可以调制具有不同频率的光线,以便为对象的任意选择的部分提供完整的吸收光谱。

    PULSED LASER FLOW CYTOMETRY
    7.
    发明申请
    PULSED LASER FLOW CYTOMETRY 审中-公开
    脉冲激光流式细胞仪

    公开(公告)号:WO1992008120A1

    公开(公告)日:1992-05-14

    申请号:PCT/AU1991000498

    申请日:1991-10-29

    Abstract: Flow cytometry comprising the steps of: producing a flow of cells of velocity (v), in single file, through an interaction region (12) of length (d), where (d) is defined by the height of a pulsed laser source (11) of height (d), which beam shines onto the flow of cells which beam defines the interaction region; pulsing the laser source at a repetition rate of (f) onto the flow of cells where the time between pulses (l/f) is approximately equal to the transit time (t) of a cell in the interaction region; collecting (15) and detecting (16) the light scattered by or fluoresced from a cell in the interaction region; analysing (17) the detected light to determine the presence or other characteristics of said cell.

    Abstract translation: 流式细胞术包括以下步骤:在单个文件中通过长度为(d)的相互作用区域(12)产生速度(v)的细胞流,其中(d)由脉冲激光源的高度 高度(d)的高度(11),该光束照射到细胞流动,该光束定义相互作用区域; 以(f)的重复速率将激光源脉冲到细胞流中,其中脉冲之间的时间(1 / f)近似等于相互作用区域中的细胞的传播时间(t); 收集(15)并检测(16)由相互作用区域中的细胞散射或发出的光; 分析(17)所检测的光以确定所述电池的存在或其它特性。

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