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    METHOD AND SYSTEM FOR JOINT DEMOSAICKING AND SPECTRAL SIGNATURE ESTIMATION
    1.
    发明申请
    METHOD AND SYSTEM FOR JOINT DEMOSAICKING AND SPECTRAL SIGNATURE ESTIMATION 审中-公开

    公开(公告)号：WO2021245374A1

    公开(公告)日：2021-12-09

    申请号：PCT/GB2021/051280

    申请日：2021-05-26

    Applicant: KING'S COLLEGE LONDON

    Inventor： VERCAUTEREN, Tom ,  EBNER, Michael ,  XIE, Yijing ,  NABAVI, Eli

    IPC: G01J3/28 ,  G01J3/02 ,  A61B1/00 ,  A61B5/00 ,  G06T5/00 ,  G01J3/12 ,  H04N9/04 ,  A61B1/00009 ,  A61B5/0075 ,  G01J2003/1217 ,  G01J2003/283 ,  G01J3/0202 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/2823 ,  H04N5/332 ,  H04N9/04515 ,  H04N9/04559

    Abstract: Embodiments of the invention provide a method and system that allows parameters of a desired target image to be determined from hyperspectral imagery of scene. The parameters may be representative of various aspects of the scene being imaged, particularly representative of physical properties of the scene. For example, in some medical imaging contexts, the property being imaged may be blood perfusion or oxygenation saturation level information per pixel. In one embodiment the parameters are obtained by collecting lower temporal and spatial resolution hyperspectral imagery, and then building a virtual hypercube of the information having a higher spatial resolution using a spatiospectral aware demosaicking process, the virtual hypercube then being used for estimation of the desired parameters at the higher spatial resolution. Alternatively, in another embodiment, instead of building the virtual hypercube and then performing the estimation, a joint demosaicking and parameter estimation operation is performed to obtain the parameters. Various white level and spectral calibration operations may also be performed to improve the results obtained. While establishing functional and technical requirements of an intraoperative system for surgery, we present iHSI system embodiments that allows for real-time wide-field HSI and responsive surgical guidance in a highly constrained operating theatre. Two exemplar embodiments exploiting state-of-the-art industrial HSI cameras, respectively using linescan and snapshot imaging technology, were investigated by performing assessments against established design criteria and ex vivo tissue experiments. We further report the use of one real-time iHSI embodiment during an ethically-approved in-patient clinical feasibility case study as part of a spinal fusion surgery therefore successfully validating our assumptions that our invention can be seamlessly integrated into the operating theatre without interrupting the surgical workflow.

    METHOD FOR SELECTION OF RAMAN EXCITATION WAVELENGTHS IN MULTI-SOURCE RAMAN PROBE
    2.
    发明申请
    METHOD FOR SELECTION OF RAMAN EXCITATION WAVELENGTHS IN MULTI-SOURCE RAMAN PROBE 审中-公开

    公开(公告)号：WO2021195471A1

    公开(公告)日：2021-09-30

    申请号：PCT/US2021/024310

    申请日：2021-03-26

    Applicant: INNOVATIVE PHOTONIC SOLUTIONS, INC.

    Inventor： CHARACHE, Greg W. ,  RUDDER, Scott L.

    IPC: G01N21/65 ,  G01J3/44 ,  G01J3/02 ,  G01J2003/4424 ,  G01J3/027

    Abstract: This invention relates to the field of spectroscopy and more particularly to a compact Raman spectroscopy system and method for providing enhanced quantitative analysis for process con-trol. The invention further relates to a Raman probe device for use in a Raman spectroscopy system. The method comprises the steps of : selecting a first excitation wavelength based on at least one characteristic of a target object; determining a range of a first Raman signal associated with said first excitation wavelength; determining a peak quantum efficiency value within the determined range of a quantum efficiency curve associated with said spectrometer; determining a Raman shifted peak of in-terest for the target object; and determining a second excita-tion wavelength based on the peak quantum efficiency value and the Raman shifted peak of interest.

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